Imperial College London
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ProfessorJamilMayet

Faculty of Medicine, National Heart & Lung Institute

Professor of Cardiology
 
 
 
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Contact

 

+44 (0)20 7594 1006j.mayet

 
 
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Assistant

 

Miss Juliet Holmes +44 (0)20 7594 5735

 
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Location

 

NHLI offices,Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cook:2017:10.1001/jamacardio.2017.1314,
author = {Cook, CM and Petraco, R and Shun-Shin, MJ and Ahmad, Y and Nijjer, S and Al-Lamee, R and Kikuta, Y and Shiono, Y and Mayet, J and Francis, DP and Sen, S and Davies, JE},
doi = {10.1001/jamacardio.2017.1314},
journal = {JAMA Cardiology},
pages = {803--810},
title = {Diagnostic accuracy of computed tomography-derived fractional flow reserve a systematic review},
url = {http://dx.doi.org/10.1001/jamacardio.2017.1314},
volume = {2},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Importance  Computed tomography–derived fractional flow reserve (FFR-CT) is a novel, noninvasive test for myocardial ischemia. Clinicians using FFR-CT must be able to interpret individual FFR-CT results to determine subsequent patient care.Objective  To provide clinicians a means of interpreting individual FFR-CT results with respect to the range of invasive FFRs that this interpretation might likely represent.Evidence Review  We performed a systematic review in accordance with guidelines from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A systematic search of MEDLINE (January 1, 2011, to 2016, week 2) and EMBASE (January 1, 2011, to 2016, week 2) was performed for studies assessing the diagnostic accuracy of FFR-CT. Title words used were computed tomography or computed tomographic and fractional flow reserve or FFR. Results were limited to publications in peer-reviewed journals. Duplicate studies and abstracts from scientific meetings were removed. All of the retrieved studies, including references, were reviewed.Findings  There were 908 vessels from 536 patients in 5 studies included in the analysis. A total of 365 (68.1%) were male, and the mean (SD) age was 63.2 (9.5) years. The overall per-vessel diagnostic accuracy of FFR-CT was 81.9% (95% CI, 79.4%-84.4%). For vessels with FFR-CT values below 0.60, 0.60 to 0.70, 0.70 to 0.80, 0.80 to 0.90, and above 0.90, diagnostic accuracy of FFR-CT was 86.4% (95% CI, 78.0%-94.0%), 74.7% (95% CI, 71.9%-77.5%), 46.1% (95% CI, 42.9%-49.3%), 87.3% (95% CI, 85.1%-89.5%), and 97.9% (95% CI, 97.9%-98.8%), respectively. The 82% (overall) diagnostic accuracy threshold was met for FFR-CT values lower than 0.63 or above 0.83. More stringent 95% and 98% diagnostic accuracy thresholds were met for FFR-CT values lower than 0.53 or above 0.93 and lower than 0.47 or above 0.99, respectively.Conclusions and Relevance  The diagnostic accuracy of FFR-CT varies markedly across the spectrum of disease. This ana
AU  - Cook,CM
AU  - Petraco,R
AU  - Shun-Shin,MJ
AU  - Ahmad,Y
AU  - Nijjer,S
AU  - Al-Lamee,R
AU  - Kikuta,Y
AU  - Shiono,Y
AU  - Mayet,J
AU  - Francis,DP
AU  - Sen,S
AU  - Davies,JE
DO  - 10.1001/jamacardio.2017.1314
EP  - 810
PY  - 2017///
SN  - 2380-6591
SP  - 803
TI  - Diagnostic accuracy of computed tomography-derived fractional flow reserve a systematic review
T2  - JAMA Cardiology
UR  - http://dx.doi.org/10.1001/jamacardio.2017.1314
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405902900020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/51390
VL  - 2
ER  -
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