Imperial College London


Faculty of MedicineDepartment of Medicine

Imperial College Research Fellow







E517Burlington DanesHammersmith Campus






BibTex format

author = {Turton, S and Myers, JF and Mick, I and Colasanti, A and Venkataraman, A and Durant, C and Waldman, A and Brailsford, A and Parkin, MC and Dawe, G and Rabiner, EA and Gunn, RN and Lightman, SL and Nutt, DJ and Lingford-Hughes, A},
doi = {10.1038/s41380-018-0107-4},
journal = {Mol Psychiatry},
title = {Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals.},
url = {},
year = {2018}

RIS format (EndNote, RefMan)

AB - Addiction has been proposed as a 'reward deficient' state, which is compensated for with substance use. There is growing evidence of dysregulation in the opioid system, which plays a key role in reward, underpinning addiction. Low levels of endogenous opioids are implicated in vulnerability for developing alcohol dependence (AD) and high mu-opioid receptor (MOR) availability in early abstinence is associated with greater craving. This high MOR availability is proposed to be the target of opioid antagonist medication to prevent relapse. However, changes in endogenous opioid tone in AD are poorly characterised and are important to understand as opioid antagonists do not help everyone with AD. We used [11C]carfentanil, a selective MOR agonist positron emission tomography (PET) radioligand, to investigate endogenous opioid tone in AD for the first time. We recruited 13 abstinent male AD and 15 control participants who underwent two [11C]carfentanil PET scans, one before and one 3 h following a 0.5 mg/kg oral dose of dexamphetamine to measure baseline MOR availability and endogenous opioid release. We found significantly blunted dexamphetamine-induced opioid release in 5 out of 10 regions-of-interest including insula, frontal lobe and putamen in AD compared with controls, but no significantly higher MOR availability AD participants compared with HC in any region. This study is comparable to our previous results of blunted dexamphetamine-induced opioid release in gambling disorder, suggesting that this dysregulation in opioid tone is common to both behavioural and substance addictions.
AU - Turton,S
AU - Myers,JF
AU - Mick,I
AU - Colasanti,A
AU - Venkataraman,A
AU - Durant,C
AU - Waldman,A
AU - Brailsford,A
AU - Parkin,MC
AU - Dawe,G
AU - Rabiner,EA
AU - Gunn,RN
AU - Lightman,SL
AU - Nutt,DJ
AU - Lingford-Hughes,A
DO - 10.1038/s41380-018-0107-4
PY - 2018///
TI - Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals.
T2 - Mol Psychiatry
UR -
UR -
UR -
ER -