Imperial College London


Faculty of MedicineDepartment of Medicine

Imperial College Research Fellow







E517Burlington DanesHammersmith Campus






BibTex format

author = {Lingford-Hughes, A and Myers, J and Watson, B and Reid, AG and Kalk, N and Feeney, A and Hammers, A and Riaño-Barros, DA and McGinnity, CJ and Taylor, LG and Rosso, L and Brooks, DJ and Turkheimer, F and Nutt, DJ},
doi = {10.1016/j.neuroimage.2016.02.005},
journal = {Neuroimage},
pages = {1--7},
title = {Using [11C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism},
url = {},
volume = {132},
year = {2016}

RIS format (EndNote, RefMan)

AB - The importance of the GABA-benzodiazepine receptor complex and its subtypes are increasingly recognised inaddiction. Using the α1/α5 benzodiazepine receptor PET radioligand [ 23 11C]Ro15 4513, we previously showed reducedbinding in the nucleus accumbens and hippocampus in abstinent alcohol dependence. We proposed that 24reduced [ 25 11C]Ro15 4513 binding in the nucleus accumbens was a marker of addiction whilst the reduction in hippocampusand positive relationship with memory was a consequence of chronic alcohol abuse. To examine this 26further we assessed [ 27 11C]Ro15 4513 binding in another addiction, opiate dependence, and used spectral analysisto estimate contributions of α1 and α5 subtypes to [ 28 11C]Ro15 4513 binding in opiate and previously acquired alcohol-dependentgroups. Opiate substitute maintained opiate-dependent men (n = 12) underwent an [ 29 11C]Ro154513 PET scan and compared with matched healthy controls (n = 13). We found a significant reduction in 30[ 31 11C]Ro15 4513 binding in the nucleus accumbens in the opiate-dependent compared with the healthy controlgroup. There was no relationship between [ 32 11C]Ro15 4513 binding in the hippocampus with memory. Wefound that reduced [ 33 11C]Ro15 4513 binding was associated with reduced α5 but not α1 subtypes in the opiate-dependentgroup. This was also seen in an alcohol-dependent group where an association between memory 34performance and [ 35 11C]Ro15 4513 binding was primarily driven by α5 and not α1 subtype. We suggest that reducedα5 levels in the nucleus accumbens are associated with addiction since we have now shown this in depen- 36dence to two pharmacologically different substances, alcohol and opiates.
AU - Lingford-Hughes,A
AU - Myers,J
AU - Watson,B
AU - Reid,AG
AU - Kalk,N
AU - Feeney,A
AU - Hammers,A
AU - Riaño-Barros,DA
AU - McGinnity,CJ
AU - Taylor,LG
AU - Rosso,L
AU - Brooks,DJ
AU - Turkheimer,F
AU - Nutt,DJ
DO - 10.1016/j.neuroimage.2016.02.005
EP - 7
PY - 2016///
SN - 1095-9572
SP - 1
TI - Using [11C]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism
T2 - Neuroimage
UR -
UR -
VL - 132
ER -