Imperial College London

DrJimMyers

Faculty of MedicineDepartment of Medicine

Imperial College Research Fellow
 
 
 
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Contact

 

j.myers

 
 
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Location

 

E517Burlington DanesHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

38 results found

Durant CF, Paterson LM, Turton S, Wilson SJ, Myers JFM, Muthukumaraswamy S, Venkataraman A, Mick I, Paterson S, Jones T, Nahar LK, Cordero RE, Nutt DJ, Lingford-Hughes Aet al., 2018, Using Baclofen to Explore GABA-B Receptor Function in Alcohol Dependence: Insights From Pharmacokinetic and Pharmacodynamic Measures, FRONTIERS IN PSYCHIATRY, Vol: 9, ISSN: 1664-0640

JOURNAL ARTICLE

Tyacke RJ, Myers JFM, Venkataraman A, Mick I, Turton S, Passchier J, Husbands SM, Rabiner EA, Gunn RN, Murphy PS, Parker CA, Nutt DJet al., 2018, Evaluation of C-11-BU99008, a PET Ligand for the Imidazoline(2) Binding Site in Human Brain, JOURNAL OF NUCLEAR MEDICINE, Vol: 59, Pages: 1597-1602, ISSN: 0161-5505

JOURNAL ARTICLE

Venkataraman AV, Keat N, Myers JF, Turton S, Mick I, Gunn RN, Rabiner EA, Passchier J, Parker CA, Tyacke RJ, Nutt DJet al., 2018, First evaluation of PET-based human biodistribution and radiation dosimetry of C-11-BU99008, a tracer for imaging the imidazoline(2) binding site, EJNMMI RESEARCH, Vol: 8, ISSN: 2191-219X

JOURNAL ARTICLE

Turton S, Myers JF, Mick I, Colasanti A, Venkataraman A, Durant C, Waldman A, Brailsford A, Parkin MC, Dawe G, Rabiner EA, Gunn RN, Lightman SL, Nutt DJ, Lingford-Hughes Aet al., 2018, Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol-dependent individuals., Mol Psychiatry

Addiction has been proposed as a 'reward deficient' state, which is compensated for with substance use. There is growing evidence of dysregulation in the opioid system, which plays a key role in reward, underpinning addiction. Low levels of endogenous opioids are implicated in vulnerability for developing alcohol dependence (AD) and high mu-opioid receptor (MOR) availability in early abstinence is associated with greater craving. This high MOR availability is proposed to be the target of opioid antagonist medication to prevent relapse. However, changes in endogenous opioid tone in AD are poorly characterised and are important to understand as opioid antagonists do not help everyone with AD. We used [11C]carfentanil, a selective MOR agonist positron emission tomography (PET) radioligand, to investigate endogenous opioid tone in AD for the first time. We recruited 13 abstinent male AD and 15 control participants who underwent two [11C]carfentanil PET scans, one before and one 3 h following a 0.5 mg/kg oral dose of dexamphetamine to measure baseline MOR availability and endogenous opioid release. We found significantly blunted dexamphetamine-induced opioid release in 5 out of 10 regions-of-interest including insula, frontal lobe and putamen in AD compared with controls, but no significantly higher MOR availability AD participants compared with HC in any region. This study is comparable to our previous results of blunted dexamphetamine-induced opioid release in gambling disorder, suggesting that this dysregulation in opioid tone is common to both behavioural and substance addictions.

JOURNAL ARTICLE

Dukart J, Holiga S, Chatham C, Hawkins P, Forsyth A, McMillan R, Myers J, Lingford-Hughes AR, Nutt DJ, Merlo-Pich E, Risterucci C, Boak L, Umbricht D, Schobel S, Liu T, Mehta MA, Zelaya FO, Williams SC, Brown G, Paulus M, Honey GD, Muthukumaraswamy S, Hipp J, Bertolino A, Sambataro Fet al., 2018, Cerebral blood flow predicts differential neurotransmitter activity, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Mick I, Ramos AC, Myers J, Stokes PR, Chandrasekera S, Erritzoe D, Mendez MA, Gunn RN, Rabiner EA, Searle GE, Galduroz JCF, Waldman AD, Bowden-Jones H, Clark L, Nutt DJ, Lingford-Hughes ARet al., 2017, Evidence for GABA-A receptor dysregulation in gambling disorder: correlation with impulsivity, ADDICTION BIOLOGY, Vol: 22, Pages: 1601-1609, ISSN: 1355-6215

JOURNAL ARTICLE

Bloomfield P, Brigadoi S, Rizzo G, Veronese Met al., 2017, Basic Neuroimaging A Guide to the Methods and Their Applications, Publisher: Createspace Independent Publishing Platform, ISBN: 9781978133617

With this initiative we are looking to provide a comprehensive background to neuroimaging for students and professionals alike. In this text, we focus on a range of imaging modalities currently used in neurosciences.

BOOK

Myers JFM, Comley RA, Gunn RN, 2017, Quantification of [C-11]Ro15-4513 GABA(A)5 specific binding and regional selectivity in humans, JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 37, Pages: 2137-2148, ISSN: 0271-678X

JOURNAL ARTICLE

Turton S, Mick I, Myers J, Colasanti A, Bowden-Jones H, Clark L, Rabiner EA, Gunn RN, Nutt DJ, Lingford-Hughes Aet al., 2017, Comparing m-opioid receptor availability and opioid/beta-endorphin release between individuals with gambling disorder, alcohol dependence and healthy volunteers using [C-11]carfentanil PET and dexamphetamine challenge, 28th International Symposium on Cerebral Blood Flow, Metabolism and Function / 13th International Conference on Quantification of Brain Function with PET, Publisher: SAGE PUBLICATIONS INC, Pages: 97-97, ISSN: 0271-678X

CONFERENCE PAPER

Magazzini L, Muthukumaraswamy SD, Campbell AE, Hamandi K, Lingford-Hughes A, Myers JFM, Nutt DJ, Sumner P, Wilson SJ, Singh KDet al., 2016, Significant reductions in human visual gamma frequency by the gaba reuptake inhibitor tiagabine revealed by robust peak frequency estimation, HUMAN BRAIN MAPPING, Vol: 37, Pages: 3882-3896, ISSN: 1065-9471

JOURNAL ARTICLE

Turton S, Myers J, Mick I, Rabiner E, Gunn R, Nutt D, Lingford-Hughes Aet al., 2016, Alcohol dependent patients have blunted endogenous opioid release measured using [C-11] carfentanil PET and dexamphetamine challenge, 29th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S676-S677, ISSN: 0924-977X

CONFERENCE PAPER

Myers J, Comley R, Gunn R, 2016, QUANTIFICATION OF [11C]RO15-4513 SPECIFIC BINDING AND SELECTIVITY IN VIVO., JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, Vol: 36, Pages: 623-624, ISSN: 0271-678X

JOURNAL ARTICLE

Mick I, Myers J, Ramos AC, Stokes PRA, Erritzoe D, Colasanti A, Gunn RN, Rabiner EA, Searle GE, Waldman AD, Parkin MC, Brailsford AD, Galduroz JCF, Bowden-Jones H, Clark L, Nutt DJ, Lingford-Hughes ARet al., 2016, Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers, NEUROPSYCHOPHARMACOLOGY, Vol: 41, Pages: 1742-1750, ISSN: 0893-133X

JOURNAL ARTICLE

Lingford-Hughes A, Myers J, Watson B, Reid AG, Kalk N, Feeney A, Hammers A, Riano-Barros DA, McGinnity CJ, Taylor LG, Rosso L, Brooks DJ, Turkheimer F, Nutt DJet al., 2016, Using [C-11]Ro15 4513 PET to characterise GABA-benzodiazepine receptors in opiate addiction: Similarities and differences with alcoholism, NEUROIMAGE, Vol: 132, Pages: 1-7, ISSN: 1053-8119

JOURNAL ARTICLE

Myers JFM, Nutt DJ, Lingford-Hughes AR, 2016, gamma-aminobutyric acid as a metabolite: Interpreting magnetic resonance spectroscopy experiments, JOURNAL OF PSYCHOPHARMACOLOGY, Vol: 30, Pages: 422-427, ISSN: 0269-8811

JOURNAL ARTICLE

Mick I, Myers J, Ramos AC, Stokes PR, Erritzoe D, Colasanti A, Gunn RN, Rabiner EA, Searle GE, Waldman AD, Parkin MC, Brailsford AD, Galduroz JCF, Bowden-Jones H, Clark L, Nutt DJ, Lingford-Hughes ARet al., 2016, Blunted Endogenous Opioid Release Following an Oral Amphetamine Challenge in Pathological Gamblers, Publisher: AKADEMIAI KIADO RT, Pages: 30-30, ISSN: 2062-5871

CONFERENCE PAPER

Nutt D, Wilson S, Lingford-Hughes A, Myers J, Papadopoulos A, Muthukumaraswamy Set al., 2015, Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: A study in healthy volunteers, NEUROPHARMACOLOGY, Vol: 88, Pages: 155-163, ISSN: 0028-3908

JOURNAL ARTICLE

Quelch D, De Santis V, Strege A, Myers J, Wells L, Nutt D, Lingford-Hughes A, Parker C, Tyacke Ret al., 2015, Influence of Agonist Induced Internalization on [H-3]Ro15-4513 Binding-An Application to Imaging Fluctuations in Endogenous GABA With Positron Emission Tomography, SYNAPSE, Vol: 69, Pages: 60-65, ISSN: 0887-4476

JOURNAL ARTICLE

Mick I, Myers J, Stokes PRA, Erritzoe D, Colasanti A, Bowden-Jones H, Clark L, Gunn RN, Rabiner EA, Searle GE, Waldman AD, Parkin MC, Brailsford AD, Nutt DJ, Lingford-Hughes ARet al., 2014, Amphetamine induced endogenous opioid release in the human brain detected with [C-11]carfentanil PET: replication in an independent cohort, INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, Vol: 17, Pages: 2069-2074, ISSN: 1461-1457

JOURNAL ARTICLE

Watson BJ, Taylor LG, Reid AG, Wilson SJ, Stokes PR, Brooks DJ, Myers JF, Turkheimer FE, Nutt DJ, Lingford-Hughes ARet al., 2014, Investigating expectation and reward in human opioid addiction with [C-11]raclopride PET, ADDICTION BIOLOGY, Vol: 19, Pages: 1032-1040, ISSN: 1355-6215

JOURNAL ARTICLE

Mick I, Myers J, Stokes P, Colasanti A, Erritzoe D, Gunn R, Clark L, Rabiner EA, Lingford-Hughes A, Nutt Det al., 2014, Endogenous opioid release in pathological gamblers after an oral amphetamine challenge: a [C-11]carfentanil PET study, 27th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S699-S700, ISSN: 0924-977X

CONFERENCE PAPER

Stokes PRA, Myers JF, Kalk NJ, Watson BJ, Erritzoe D, Wilson SJ, Cunningham VJ, Barros DR, Hammers A, Turkheimer FE, Nutt DJ, Lingford-Hughes ARet al., 2014, Acute increases in synaptic GABA detectable in the living human brain: A [C-11]Ro15-4513 PET study, NEUROIMAGE, Vol: 99, Pages: 158-165, ISSN: 1053-8119

JOURNAL ARTICLE

Myers JFM, Evans CJ, Kalk NJ, Edden RAE, Lingford-Hughes ARet al., 2014, Measurement of GABA Using J-Difference Edited H-1-MRS Following Modulation of Synaptic GABA Concentration with Tiagabine, SYNAPSE, Vol: 68, Pages: 355-362, ISSN: 0887-4476

JOURNAL ARTICLE

Mick I, Myers J, Stokes P, Colasanti A, Erritzoe D, Searle G, Gunn R, Rabiner I, Lingford-Hughes A, Nutt Det al., 2014, Endogenous opioid release in pathological gamblers after an oral amphetamine challenge: a [C-11]carfentanil PET study, ECNP Workshop for Junior Scientists in Europe, Publisher: ELSEVIER SCIENCE BV, Pages: S62-S63, ISSN: 0924-977X

CONFERENCE PAPER

Hamandi K, Myers J, Muthukumaraswamy S, 2014, Tiagabine-induced stupor - More evidence for an encephalopathy, EPILEPSY & BEHAVIOR, Vol: 31, Pages: 196-197, ISSN: 1525-5050

JOURNAL ARTICLE

Muthukumaraswamy SD, Myers JFM, Wilson SJ, Nutt DJ, Hamandi K, Lingford-Hughes A, Singh KDet al., 2013, Elevating Endogenous GABA Levels with GAT-1 Blockade Modulates Evoked but Not Induced Responses in Human Visual Cortex, NEUROPSYCHOPHARMACOLOGY, Vol: 38, Pages: 1105-1112, ISSN: 0893-133X

JOURNAL ARTICLE

Mendez MA, Horder J, Myers J, Coghlan S, Stokes P, Erritzoe D, Howes O, Lingford-Hughes A, Murphy D, Nutt Det al., 2013, The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: A pilot [C-11]Ro15-4513 positron emission tomography study, NEUROPHARMACOLOGY, Vol: 68, Pages: 195-201, ISSN: 0028-3908

JOURNAL ARTICLE

Stokes PRA, Benecke A, Myers J, Erritzoe D, Watson BJ, Kalk N, Barros DR, Hammers A, Nutt DJ, Lingford-Hughes ARet al., 2013, History of cigarette smoking is associated with higher limbic GABA(A) receptor availability, NEUROIMAGE, Vol: 69, Pages: 70-77, ISSN: 1053-8119

JOURNAL ARTICLE

Muthukumaraswamy SD, Myers JFM, Wilson SJ, Nutt DJ, Lingford-Hughes A, Singh KD, Hamandi Ket al., 2013, The effects of elevated endogenous GABA levels on movement-related network oscillations, NEUROIMAGE, Vol: 66, Pages: 36-41, ISSN: 1053-8119

JOURNAL ARTICLE

Lingford-Hughes A, Myers JF, Watson B, Stokes PR, Kalk NJ, Rosso L, Brooks DJ, Turkheimer F, Wilson SJ, Nutt DJet al., 2012, Imaging GABA-benzodiazepine receptor subtypes in addiction, 25th Congress of the European-College-of-Neuropsychopharmacology (ECNP), Publisher: ELSEVIER SCIENCE BV, Pages: S133-S133, ISSN: 0924-977X

CONFERENCE PAPER

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