Imperial College London
Alternate

Emeritus ProfessorJeremyNicholson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Hoyles:2018:10.1186/s40168-018-0439-y,
author = {Hoyles, L and Snelling, T and Umlai, UK and Nicholson, JK and Carding, SR and Glen, RC and McArthur, S},
doi = {10.1186/s40168-018-0439-y},
journal = {Microbiome},
title = {Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier},
url = {http://dx.doi.org/10.1186/s40168-018-0439-y},
volume = {6},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: Gut microbiota composition and function are symbiotically linked with host health, and altered in metabolic, inflammatory and neurodegenerative disorders. Three recognized mechanisms exist by which the microbiome influences the gut--brain axis: modification of autonomic/sensorimotor connections, immune activation, and neuroendocrine pathway regulation. We hypothesized interactions between circulating gut-derived microbial metabolites and the blood--brain barrier (BBB) also contribute to the gut--brain axis. Propionate, produced from dietary substrates by colonic bacteria, stimulates intestinal gluconeogenesis and is associated with reduced stress behaviours, but its potential endocrine role has not been addressed. Results: After demonstrating expression of the propionate receptor FFAR3 on human brain endothelium, we examined the impact of a physiologically relevant propionate concentration (1 μM) on BBB properties in vitro. Propionate inhibited pathways associated with non-specific microbial infections via a CD14-dependent mechanism, suppressed expression of LRP-1 and protected the BBB from oxidative stress via NRF2 (NFE2L2) signaling. Conclusions: Together, these results suggest gut-derived microbial metabolites interact with the BBB, representing a fourth facet of the gut--brain axis that warrants further attention.
AU  - Hoyles,L
AU  - Snelling,T
AU  - Umlai,UK
AU  - Nicholson,JK
AU  - Carding,SR
AU  - Glen,RC
AU  - McArthur,S
DO  - 10.1186/s40168-018-0439-y
PY  - 2018///
SN  - 2049-2618
TI  - Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier
T2  - Microbiome
UR  - http://dx.doi.org/10.1186/s40168-018-0439-y
UR  - http://hdl.handle.net/10044/1/57884
VL  - 6
ER  -
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