Imperial College London
Alternate

Emeritus ProfessorJeremyNicholson

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Emeritus Professor of Biological Chemistry
 
 
 
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Contact

 

+44 (0)20 7594 3195j.nicholson Website

 
 
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Assistant

 

Ms Wendy Torto +44 (0)20 7594 3225

 
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Location

 

Office no. 665Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@unpublished{Hoyles:2018:10.1186/s40168-018-0439-y,
author = {Hoyles, L and Snelling, T and Umlai, U-K and Nicholson, J and Carding, S and Glen, R and McArthur, S},
doi = {10.1186/s40168-018-0439-y},
publisher = {biorixiv},
title = {Microbiome–host interactions: protective effects of propionate upon the blood–brain barrier},
url = {http://dx.doi.org/10.1186/s40168-018-0439-y},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - UNPB
AB  - Breakdown of foodstuffs by the gut microbiota results in the production of the short-chain fatty acids (SCFAs) acetate, propionate and butyrate. SFCAs are potent bioactive molecules, providing energy for intestinal cells, enhancing satiety and positively influencing metabolic health. They also influence the gut–brain axis. The gut microbiota and/or its bioactive molecules contribute to maintaining the integrity of the blood–brain barrier (BBB), the primary defensive structure of the brain. Propionate is produced by the gut microbiota from the breakdown of glucans found in whole grains, mushrooms and yeast products. It is found in the blood at ≤1 μM. At this physiologically relevant concentration, propionate enhances BBB integrity, mitigating against deleterious inflammatory and oxidative stimuli known to contribute to neurological and psychological diseases. Therefore, there is the potential that dietary supplementation with glucan-containing products may offer protection of the brain against detrimental stimuli.
AU  - Hoyles,L
AU  - Snelling,T
AU  - Umlai,U-K
AU  - Nicholson,J
AU  - Carding,S
AU  - Glen,R
AU  - McArthur,S
DO  - 10.1186/s40168-018-0439-y
PB  - biorixiv
PY  - 2018///
TI  - Microbiome–host interactions: protective effects of propionate upon the blood–brain barrier
UR  - http://dx.doi.org/10.1186/s40168-018-0439-y
UR  - https://www.biorxiv.org/content/10.1101/170548v3
UR  - http://hdl.handle.net/10044/1/72589
ER  -
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