Imperial College London

ProfessorJohnWarner

Faculty of MedicineDepartment of Medicine

Chair in Paediatrics
 
 
 
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Contact

 

j.o.warner

 
 
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Assistant

 

Dr Robert Boyle +44 (0)20 7594 3990

 
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Location

 

246Medical SchoolSt Mary's Campus

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Summary

 

Publications

Publication Type
Year
to

731 results found

Khaleva E, Gridneva Z, Geddes DT, Oddy WH, Colicino S, Blyuss O, Boyle R, Warner J, Munblit Det al., 2019, Transforming growth factor beta in human milk and allergic outcomes in children: a systematic review., Clin Exp Allergy

BACKGROUND: Human milk (HM) transforming growth factor beta (TGF-β) is critical for inflammation regulation and oral tolerance promotion. Previous reports suggested that variations in HM TGF-β levels are associated with allergic outcomes. OBJECTIVE: We undertook a systematic review (PROSPERO 2017 CRD42017069920) to reassess the evidence on the relationships between HM TGF-β and allergic outcomes in children. METHODS: Electronic bibliographic databases (MEDLINE, EMBASE, Cochrane Library) were systematically searched. Two independent reviewers screened reference lists, extracted the data and assessed risk of bias using the National Institute for Clinical Excellence methodological checklist. RESULTS: A total of 21 studies were identified. Sixteen studies assessed relationships between HM TGF-β and risk of eczema; 14, allergic sensitisation; 9, wheezing/asthma; 6, food allergy; 3, allergic rhinitis/conjunctivitis. Five cohorts (5/18, 28%) reported a protective effect of TGF-β1, while 3 (3/10, 30%) suggested increased risk of allergic outcomes development and 1 (1/10, 10%), a protective effect of TGF-β2 on eczema. Meta-analysis was not possible due to significant heterogeneity in methodology, age of outcome assessment and differing statistical approaches. 71% (15/21) of studies carried a high risk of bias. CONCLUSION AND CLINICAL RELEVANCE: In contrast with previous findings we did not find strong evidence of associations between HM TGF-β and allergic outcomes. Differences in studies' methodology and outcomes do not allow unconditional rejection or acceptance of the hypothesis that HM TGF-β influences the risk of allergy development. Future studies on diverse populations employing standardised methods, accurate phenotyping of outcomes and evaluation of the effect of TGF-β in combination with other HM immune markers, microbiome and oligosaccharides are required. This article is protected by copyright. All rights reserved.

JOURNAL ARTICLE

Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJM, Habibi MS, Johnston SL, Hansel TT, Levin M, Thwaites RS, Warner JO, Cookson WO, Gazzard BG, Hay A, McCauley J, Aylin P, Ashby D, Barclay WS, Elderfield RA, Nadel S, Herberg JA, Drumright LN, Garcia-Alvarez L, Holmes AH, Kon OM, Aston SJ, Gordon SB, Hussell T, Thompson C, Zambon MC, Baillie KJ, Hume DA, Simmonds P, Hayward A, Smyth RL, McNamara PS, Semple MG, Nguyen-Van-Tam JS, Ho L-P, McMichael AJ, Kellam P, Adamson WE, Carman WF, Griffiths MJet al., 2019, Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza (vol 19, pg 625, 2018), NATURE IMMUNOLOGY, Vol: 20, Pages: 373-373, ISSN: 1529-2908

JOURNAL ARTICLE

Bjermer L, Eriksson G, Radner F, Peterson S, Warner JOet al., 2019, Time to onset of improvements in Quality of Life from Temperature-controlled Laminar Airflow (TLA) in severe allergic asthma, RESPIRATORY MEDICINE, Vol: 147, Pages: 19-25, ISSN: 0954-6111

JOURNAL ARTICLE

Chakravorty S, Tallett A, Witwicki C, Hay H, Mkandawire C, Ogundipe A, Ojeer P, Whitaker A, Thompson J, Sizmur S, Sathyamoorthy G, Warner JOet al., 2018, Patient-reported experience measure in sickle cell disease, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 103, Pages: 1104-1109, ISSN: 0003-9888

JOURNAL ARTICLE

Munblit D, Abrol P, Sheth S, Chow LY, Khaleva E, Asmanov A, Lauriola S, Padovani EM, Comberiati P, Boner AL, Warner JO, Boyle RJ, Peroni DGet al., 2018, Levels of Growth Factors and IgA in the Colostrum of Women from Burundi and Italy, NUTRIENTS, Vol: 10, ISSN: 2072-6643

JOURNAL ARTICLE

Khaleva E, Gridneva Z, Geddes D, Oddy WH, Boyle R, Warner J, Munblit Det al., 2018, TGF-beta in human milk and allergic outcomes in children: A systematic review, Congress of the European-Academy-of-Allergy-and-Clinical-Immunology (EAACI), Publisher: WILEY, Pages: 682-683, ISSN: 0105-4538

CONFERENCE PAPER

Mavroudi A, Chrysochoou E-A, Boyle RJ, Trypsianis G, Xinias I, Cassimos D, Imvrios G, Katotomichelakis M, Karagiannidou A, Karantaglis N, Kourentas G, Warner JOet al., 2018, Validation of the Children's Sleep Habits Questionnaire in a sample of Greek children with allergic rhinitis, ALLERGOLOGIA ET IMMUNOPATHOLOGIA, Vol: 46, Pages: 389-393, ISSN: 0301-0546

JOURNAL ARTICLE

Ulfman LH, Leusen JHW, Savelkoul HFJ, Warner JO, van Neerven RJJet al., 2018, Effects of Bovine Immunoglobulins on Immune Function, Allergy, and Infection, FRONTIERS IN NUTRITION, Vol: 5, ISSN: 2296-861X

JOURNAL ARTICLE

Dunning J, Blankley S, Hoang LT, Cox M, Graham CM, James PL, Bloom CI, Chaussabel D, Banchereau J, Brett SJ, Moffatt MF, O'Garra A, Openshaw PJMet al., 2018, Progression of whole-blood transcriptional signatures from interferon-induced to neutrophil-associated patterns in severe influenza, NATURE IMMUNOLOGY, Vol: 19, Pages: 625-+, ISSN: 1529-2908

JOURNAL ARTICLE

Wopereis H, Sim K, Shaw A, Warner JO, Knol J, Kroll JSet al., 2018, Intestinal microbiota in infants at high risk for allergy: Effects of prebiotics and role in eczema development, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, Vol: 141, Pages: 1334-+, ISSN: 0091-6749

JOURNAL ARTICLE

Boyle RJ, Umasunthar T, Smith JG, Hanna H, Procktor A, Phillips K, Pinto C, Gore C, Cox HE, Warner JO, Vickers B, Hodes Met al., 2017, A brief psychological intervention for mothers of children with food allergy can change risk perception and reduce anxiety: Outcomes of a randomized controlled trial, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 47, Pages: 1309-1317, ISSN: 0954-7894

JOURNAL ARTICLE

Warner JO, Spitters SJIM, 2017, INTEGRATING CARE FOR CHILDREN WITH ALLERGIC DISEASES: THE UNITED KINGDOM EXPERIENCE, CURRENT ALLERGY & CLINICAL IMMUNOLOGY, Vol: 30, Pages: 172-178, ISSN: 1609-3607

JOURNAL ARTICLE

Levin ME, Warner JO, 2017, THE ATOPIC DANCE, CURRENT ALLERGY & CLINICAL IMMUNOLOGY, Vol: 30, Pages: 150-154, ISSN: 1609-3607

JOURNAL ARTICLE

Munblit D, Peroni DG, Boix-Amoros A, Hsu PS, Van't Land B, Gay MCL, Kolotilina A, Skevaki C, Boyle RJ, Collado MC, Garssen J, Geddes DT, Nanan R, Slupsky C, Wegienka G, Kozyrskyj AL, Warner JOet al., 2017, Human Milk and Allergic Diseases: An Unsolved Puzzle, NUTRIENTS, Vol: 9, ISSN: 2072-6643

JOURNAL ARTICLE

Munblit D, Treneva M, Korsunskiy I, Asmanov A, Pampura A, Warner JOet al., 2017, A national survey of Russian physicians' knowledge of diagnosis and management of food-induced anaphylaxis, BMJ OPEN, Vol: 7, ISSN: 2044-6055

JOURNAL ARTICLE

Munblit D, Treneva M, Peroni DG, Colicino S, Chow LY, Dissanayeke S, Pampura A, Boner AL, Geddes DT, Boyle RJ, Warner JOet al., 2017, Immune Components in Human Milk Are Associated with Early Infant Immunological Health Outcomes: A Prospective Three-Country Analysis, NUTRIENTS, Vol: 9, ISSN: 2072-6643

JOURNAL ARTICLE

Warner JO, 2017, THE FOETAL ORIGINS OF ALLERGY, CURRENT ALLERGY & CLINICAL IMMUNOLOGY, Vol: 30, Pages: 62-68, ISSN: 1609-3607

JOURNAL ARTICLE

Warner JO, 2017, Use of temperature-controlled laminar airflow in the management of atopic asthma: clinical evidence and experience, THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE, Vol: 11, Pages: 181-188, ISSN: 1753-4658

JOURNAL ARTICLE

Minshall E, Patel H, Francis N, Hansel TT, Warner JO, Boyle RJ, Fell J, Epstein Jet al., 2017, Local chemokine profiling in eosinophilic esophagitis: The synthetic absorptive matrix test, PEDIATRIC ALLERGY AND IMMUNOLOGY, Vol: 28, Pages: 100-102, ISSN: 0905-6157

JOURNAL ARTICLE

Munblit D, Treneva M, Peroni DG, Colicino S, Chow L, Dissanayeke S, Abrol P, Sheth S, Pampura A, Boner AL, Geddes DT, Boyle RJ, Warner JOet al., 2016, Colostrum and Mature Human Milk of Women from London, Moscow, and Verona: Determinants of Immune Composition, NUTRIENTS, Vol: 8, ISSN: 2072-6643

JOURNAL ARTICLE

Gore C, Griffin R, Rothenberg T, Tallett A, Hopwood B, Sizmur S, O'Keeffe C, Warner JOet al., 2016, New patient-reported experience measure for children with allergic disease: development, validation and results from integrated care, ARCHIVES OF DISEASE IN CHILDHOOD, Vol: 101, Pages: 935-943, ISSN: 0003-9888

JOURNAL ARTICLE

Wopereis H, Sim K, Shaw A, Oozeer R, Warner JO, Kroll JS, Knol Jet al., 2016, Decreased microbial conversion of lactic acid into butyrate in infants developing eczema, Meeting of the European-Academy-of-Allergy-and-Clinical-Immunology, Publisher: WILEY-BLACKWELL, Pages: 168-169, ISSN: 0105-4538

CONFERENCE PAPER

Mavroudi A, Chrysochoou E-A, Boyle RJ, Papastergiopoulos A, Karantaglis N, Karagiannidou A, Xinias L, Farmaki E, Hatziagorou E, Kirvassilis F, Kourentas G, Tsanakas J, Warner JOet al., 2016, Validation study of the pediatric allergic rhinitis quality of life questionnarie, ASIAN PACIFIC JOURNAL OF ALLERGY AND IMMUNOLOGY, Vol: 34, Pages: 159-165, ISSN: 0125-877X

JOURNAL ARTICLE

Boyle RJ, Tang ML-K, Chiang WC, Chua MC, Ismail I, Nauta A, Hourihane JO, Smith P, Gold M, Ziegler J, Peake J, Quinn P, Rao R, Brown N, Rijnierse A, Garssen J, Warner JOet al., 2016, Prebiotic-supplemented partially hydrolysed cow's milk formula for the prevention of eczema in high-risk infants: a randomized controlled trial, ALLERGY, Vol: 71, Pages: 701-710, ISSN: 0105-4538

JOURNAL ARTICLE

Turner PJ, Warner JO, 2016, Allergy, The Science of Paediatrics Mrcpch Mastercourse, Publisher: Elsevier, ISBN: 9780702063138

This book is "innovative and original in assisting the reader to apply the principles of science to paediatric practice".

BOOK CHAPTER

Brazier P, Schauer U, Hamelmann E, Holmes S, Pritchard C, Warner JOet al., 2016, Economic analysis of temperature-controlled laminar airflow (TLA) for the treatment of patients with severe persistent allergic asthma, BMJ OPEN RESPIRATORY RESEARCH, Vol: 3, ISSN: 2052-4439

JOURNAL ARTICLE

Munblit D, Sheth S, Abrol P, Treneva M, Peroni DG, Chow L-Y, Boner AL, Pampura A, Warner JO, Boyle RJet al., 2016, Exposures influencing total IgA level in colostrum, JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, Vol: 7, Pages: 61-67, ISSN: 2040-1744

JOURNAL ARTICLE

Griffiths M, Goldring S, Griffiths C, Shaheen SO, Martineau A, Cross L, Robinson S, Warner JO, Devine A, Boyle RJet al., 2015, Effects of Pre-Natal Vitamin D Supplementation with Partial Correction of Vitamin D Deficiency on Early Life Healthcare Utilisation: A Randomised Controlled Trial, PLOS ONE, Vol: 10, ISSN: 1932-6203

JOURNAL ARTICLE

Umasunthar T, Leonardi-Bee J, Turner PJ, Hodes M, Gore C, Warner JO, Boyle RJet al., 2015, Incidence of food anaphylaxis in people with food allergy: a systematic review and meta-analysis, CLINICAL AND EXPERIMENTAL ALLERGY, Vol: 45, Pages: 1621-1636, ISSN: 0954-7894

JOURNAL ARTICLE

Spergel JM, Warner JO, 2015, Pharmacotherapies Early in Life to Prevent the Atopic March, Allergy, Immunity and Tolerance in Early Childhood: The First Steps of the Atopic March, Pages: 303-319, ISBN: 9780124202269

© 2016 Elsevier Inc. All rights reserved. The progression of atopic dermatitis to asthma is considered part of the atopic march. Various strategies have been examined to prevent this progression. In related diseases such as inflammatory bowel disease, disease-modifying agents exist and affect the natural history of disease. These agents can be broken down into three broad classes: primary, secondary, and tertiary agents. Primary strategies have preliminary success in preventing atopic dermatitis with barrier creams, but additional longitudinal studies are needed to see whether the benefit is maintained. Secondary strategies using antihistamines, topical medications for atopic dermatitis or asthma, have not been able to prevent the progression of atopic dermatitis to asthma or change the natural history of asthma. However, specific immunotherapy has shown benefit in one well-designed study. Tertiary prevention agents that help with symptom and disease flare-ups are successful with the use of maintenance medications for asthma or atopic dermatitis. Additional studies are needed to find the optimal method to prevent development of the atopic march.

BOOK CHAPTER

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