Imperial College London
Alternate

Emeritus ProfessorJohnWarner

Faculty of Medicine, National Heart & Lung Institute

Emeritus in Paediatrics
 
 
 
//

Contact

 

j.o.warner

 
 
//

Location

 

246Medical SchoolSt Mary's Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Warner:2017,
author = {Warner, JO},
journal = {Current Allergy and Clinical Immunology},
pages = {62--68},
title = {The foetal origins of allergy},
url = {http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405387700002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202},
volume = {30},
year = {2017}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The dramatic increases in allergy and allergic diseases which have occurred over the past half-century have been strongly associated with changes in early life events. Changes in lifestyle, which have affected nutrition, allergen  and  microbial  exposures,  have  been  strongly  implicated  as  explanations  for  changing  allergy  susceptibility. To what extent these influences affect the foetus during pregnancy rather than the infant post-natally is uncertain. In all probability there is a sequence of events through pregnancy and early post-natal life  which  in  combination  change  the  outcomes.  Successful  pregnancy  is  associated  with  a  Th-2,  allergy-biased immunological environment which results in virtually all neonates having an apparent allergic pattern of immune responsiveness. Under normal circumstances this is rapidly down-regulated after birth, most likely affected by the evolving human microbiome. Interactions between genetic and environmental variation, both during pregnancy and in the first months of the infant’s life, perturb this normal sequence and lead to a sustained Th-2-biased allergic response. The future for prevention rests in identifying the key influences that should highlight strategies to turn the clock back to an era of low prevalence of allergic diseases.
AU  - Warner,JO
EP  - 68
PY  - 2017///
SN  - 1609-3607
SP  - 62
TI  - The foetal origins of allergy
T2  - Current Allergy and Clinical Immunology
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000405387700002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/54341
VL  - 30
ER  -
Download