Imperial College London

Jiri Pavlu

Faculty of MedicineDepartment of Medicine

Honorary Clinical Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 8117j.pavlu Website

 
 
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Location

 

Leuka Building R2.20Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

111 results found

Ainley L, Pavlu J, 2018, Ambulatory autologous stem cell transplantation for multiple myeloma and lymphoma: A single centre experience, 58th Annual Scientific Meeting of the British-Society-for-Haematology, Publisher: WILEY, Pages: 156-156, ISSN: 0007-1048

CONFERENCE PAPER

Beckerson J, Szydlo RM, Hickson M, Mactier CE, Innes AJ, Gabriel IH, Palanicawandar R, Kanfer EJ, Macdonald DH, Milojkovic D, Rahemtulla A, Chaidos A, Karadimitris A, Olavarria E, Apperley JF, Pavlu Jet al., 2018, Impact of route and adequacy of nutritional intake on outcomes of allogeneic haematopoietic cell transplantation for haematologic malignancies., Clin Nutr

BACKGROUND: Allogeneic haematopoietic cell transplantation (HCT) is often associated with poor oral intake due to painful mucositis and gastrointestinal sequalae that occur following a preparative regimen of intensive chemotherapy and/or total body radiation. Although attractive to assume that optimal nutrition improves HCT outcomes, there are limited data to support this. It is also unclear whether artificial nutrition support should be provided as enteral tube feeding or parenteral nutrition (PN). METHODS: We analysed day-100 non-relapse mortality (NRM), incidence of acute graft-versus-host disease (GvHD), acute gastrointestinal GvHD, 5-year survival and GvHD-free/relapse-free survival (GRFS) according to both route and adequacy of nutritional intake prior to neutrophil engraftment, together with other known prognostic factors, in a retrospective cohort of 484 patients who underwent allogeneic HCT for haematologic malignancy between 2000 and 2014. RESULTS: Multivariate analyses showed increased NRM with inadequate nutrition (hazard ratio (HR) 4.1; 95% confidence interval (CI) 2.2-7.2) and adequate PN (HR 2.9; 95% CI 1.6-5.4) compared to adequate enteral nutrition (EN) both P < .001. There were increased incidences of gastrointestinal GvHD of any stage and all GvHD ≥ grade 2 in patients who received PN (odds ratio (OR) 2.0; 95% CI 1.2-3.3; P = .006, and OR 1.8; 95% CI 1.1-3.0; P = .018, respectively), compared to adequate EN. Patients who received adequate PN and inadequate nutrition also had reduced probabilities of survival and GRFS at 5 years. CONCLUSION: Adequate EN during the early transplantation course is associated with reduced NRM, improved survival and GRFS at 5 years. Furthermore, adequate EN is associated with lower incidence of overall and gut acute GvHD than PN, perhaps because of its ability to maintain mucosal integrity, modulate the immune response to intensive chemo/radiotherapy and support the gastroi

JOURNAL ARTICLE

Ghani R, Mookerjee S, Mullish BH, Thursz M, Marchesi J, Pavlu J, Davies Fet al., 2018, Impact on Length of Stay and Antibiotic Use in Allogenic and Autologous Stem Cell Transplant Patients Colonized with Carbapenemase-producing Enterobacteriaceae, IDWeek, Publisher: Oxford University Press, ISSN: 2328-8957

CONFERENCE PAPER

Patel A, Szydlo RM, Auner HW, Kanfer EJ, MacDonald DH, Milojkovic D, Altaf S, Innes A, Gabriel I, Rahemtulla A, Chaidos A, Karadimitris A, Olavarria E, Apperley JF, Pavlu Jet al., 2018, C-reactive protein prior to myeloablative allogeneic haematopoietic cell transplantation identifies patients at risk of early- and long-term mortality, BRITISH JOURNAL OF HAEMATOLOGY, Vol: 180, Pages: 889-892, ISSN: 0007-1048

JOURNAL ARTICLE

Craddock C, Tholouli E, Vicente SM, Gbandi E, Houlton AE, Drummond MW, Pavlu J, Vyas Pet al., 2017, Safety and Clinical Activity of Combined Romidepsin and Azacitidine Therapy in High Risk Acute Myeloid Leukemia: Preliminary Results of the Romaza Trial, 59th Annual Meeting of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Freeman S, Hodgkinson A, Nagra S, Khan N, Ferguson P, Houlton A, Crawley C, Gilleece M, Hunter A, Novitzky-Basso I, Pavlu J, Peniket A, Potter V, Protheroe R, Salim R, Russell N, Tholouli E, Siddique S, Craddock Cet al., 2017, Tracking MRD together with LSC Enriched Populations to Predict Transplant Outcomes in AML, ANNALS OF HEMATOLOGY, Vol: 96, Pages: S23-S24, ISSN: 0939-5555

JOURNAL ARTICLE

Ghani L, Salooja N, Stuart J, Szydlo R, Apperley J, Chaidos A, Gabriel I, Jakob C, Kanfer E, Olavarria E, Macdonald D, Milojkovic D, Palanicawandar R, Pavlu J, Todd Jet al., 2017, Microalbuminuria in long-term survivors of hematopoietic cell transplant: a retrospective single-centre study, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S300-S300, ISSN: 0268-3369

CONFERENCE PAPER

Giebel S, Labopin M, Socie G, Pavlu J, Volin L, Remenyi P, Yakoub-Agha I, Orchard K, Michallet M, Stuhler G, Chaganti S, Murray M, Aljurf M, Bloor A, Passweg J, Finke J, Mohty M, Nagler Aet al., 2017, CYCLOPHOSPHAMIDE VERSUS ETOPOSIDE IN COMBINATION WITH TOTAL BODY IRRADIATION AS CONDITIONING FOR ADULTS WITH PH(-) ALL UNDERGOING ALLO-HCT. A STUDY FROM THE ACUTE LEUKEMIA WORKING PARTY OF THE EBMT, 22nd Congress of the European-Hematology-Association, Publisher: FERRATA STORTI FOUNDATION, Pages: 326-326, ISSN: 0390-6078

CONFERENCE PAPER

Innes AJ, Mullish BH, Fernando F, Adams G, Marchesi JR, Apperley JF, Brannigan E, Davies F, Pavlu Jet al., 2017, Faecal microbiota transplant: a novel biological approach to extensively drug-resistant organism-related non-relapse mortality, BONE MARROW TRANSPLANTATION, Vol: 52, Pages: 1452-1454, ISSN: 0268-3369

JOURNAL ARTICLE

Khoder A, Palanicawandar R, Atta M, Selvaratnam V, Sever M, Pello OM, Loaiza S, Bray E, Bradshaw A, Uddin S, Chaidos A, Karadimitris A, Jacob C, MacDonald D, Milojkovic D, Pavlu J, Auner H, Szydlo R, Apperley JF, Olavarria E, Kanfer Eet al., 2017, The choice between stem cell mobilisation with GCSF alone or with GCSF plus chemotherapy may impact on the stem cell transplant service, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S146-S147, ISSN: 0268-3369

CONFERENCE PAPER

Khoder A, Sever M, Palanicawandar R, Pello O, Loaiza S, Bray E, Bradshaw A, Uddin S, Atta M, Selvaratnam V, Sevillano B, Monsalvo S, Altaf S, Innes A, Lozano S, Pavlu J, Auner H, Apperley J, Olavarria E, Kanfer Eet al., 2017, PLERIXAFOR EFFECTIVELY RESCUES BIOSIMILAR G-CSFALONE-BASED STEM CELL MOBILISATION FAILURES, Publisher: ELSEVIER SCI LTD, Pages: S55-S55, ISSN: 1465-3249

CONFERENCE PAPER

Monsalvo S, Gabriel I, Sevillano B, Palanicawandar R, Innes A, Milojkovic D, Macdonald D, Chaidos A, Jakob C, Pavlu J, Nicholas R, Malik O, Kazmi M, Silber E, Kanfer E, Muraro P, Apperley JF, Olavarria Eet al., 2017, Exacerbation of multiple sclerosis symptoms in patients undergoing autologous stem cell transplantation, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S419-S420, ISSN: 0268-3369

CONFERENCE PAPER

Monsalvo S, Sevillano B, Palanicawandar R, Innes A, Milojkovic D, Gabriel I, Szydlo R, Macdonald D, Chaidos A, Jakob C, Pavlu J, Stumpfle R, Skinner L, Kanfer E, Apperley JF, Olavarria Eet al., 2017, Changes in intensive care for stem cell transplant patients: the need for response criteria at 5 days of full treatment to separate good risk patients and avoid futile interventions, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S278-S278, ISSN: 0268-3369

CONFERENCE PAPER

Pavlu J, Labopin M, Zoellner AK, Sakellari I, Stelljes M, Finke J, Fanin R, Stuhler G, Afanasyev BV, Bloor AJ, Anagnostopoulos A, Mohty M, Giebel S, Nagler Aet al., 2017, Allogeneic hematopoietic cell transplantation for primary refractory acute lymphoblastic leukemia: A report from the Acute Leukemia Working Party of the EBMT, CANCER, Vol: 123, Pages: 1965-1970, ISSN: 0008-543X

JOURNAL ARTICLE

Pavlů J, Auner HW, Szydlo RM, Sevillano B, Palani R, O'Boyle F, Chaidos A, Jakob C, Kanfer E, MacDonald D, Milojkovic D, Rahemtulla A, Bradshaw A, Olavarria E, Apperley JF, Pello OMet al., 2017, Analysis of hematopoietic recovery after autologous transplantation as method of quality control for long-term progenitor cell cryopreservation., Bone Marrow Transplant, Vol: 52, Pages: 1599-1601

Hematopoietic precursor cells (HPC) are able to restore hematopoiesis after high-dose chemotherapy and their cryopreservation is routinely employed prior to the autologous hematopoietic cell transplantation (AHCT). Although previous studies showed feasibility of long-term HPC storage, concerns remain about possible negative effects on their potency. To study the effects of long-term cryopreservation, we compared time to neutrophil and platelet recovery in 50 patients receiving two AHCT for multiple myeloma at least 2 years apart between 2006 and 2016, using HPC obtained from one mobilization and collection attempt before the first transplant. This product was divided into equivalent fractions allowing a minimum of 2 × 106 CD34+ cells/kg recipient's weight. One fraction was used for the first transplant after median storage of 60 days (range, 17-165) and another fraction was used after median storage of 1448 days (range, 849-3510) at the second AHCT. Neutrophil recovery occurred at 14 days (median; range, 11-21) after the first and 13 days (10-20) after the second AHCT. Platelets recovered at a median of 16 days after both procedures. Considering other factors, such as disease status, conditioning and HPC dose, this single institution data demonstrated no reduction in the potency of HPC after long-term storage.

JOURNAL ARTICLE

Pello OM, Bradshaw A, Innes A, Finn S-A, Uddin S, Bray E, Olavarria E, Apperley JF, Pavlu Jet al., 2017, Clinical efficacy of BK virus specific T-cells in treatment of severe refractory hemorrhagic cystitis after HLA haploidentical transplantation, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S483-S484, ISSN: 0268-3369

CONFERENCE PAPER

Pello OM, Innes AJ, Bradshaw A, Finn S-A, Uddin S, Bray E, Olavarria E, Apperley JF, Pavlu Jet al., 2017, BKV-specific T cells in the treatment of severe refractory haemorrhagic cystitis after HLA-haploidentical haematopoietic cell transplantation, EUROPEAN JOURNAL OF HAEMATOLOGY, Vol: 98, Pages: 632-634, ISSN: 0902-4441

JOURNAL ARTICLE

Sevillano B, Monsalvo S, Lozano S, Bailey C, Szydlo R, Gabriel I, Pavlu J, Milojkovic D, Palanicawandar R, Kanfer E, Olavarria E, Apperley Jet al., 2017, Ciclosporin toxicity: Increased mortality and incidence of chronic GvHD after stopping Ciclosporin A and replacing it with mycophenolate mofetil as prophylaxis for GvHD, 43rd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT), Publisher: NATURE PUBLISHING GROUP, Pages: S204-S205, ISSN: 0268-3369

CONFERENCE PAPER

Avenoso D, Bradshaw A, Innes A, de la Fuente J, Olavarria E, Apperley JF, Pavlu Jet al., 2016, Microbial Contamination of Haematopoietic Stem Cell Products: A Single Centre Experience, 58th Annual Meeting and Exposition of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Beckerson J, Szydlo RM, Hickson M, Mactier CE, Innes A, Gabriel IH, Palanicawandar R, Kanfer EJ, Macdonald D, Milojkovic D, Rahemtulla A, Chaidos A, Karadimitris A, Olavarria E, Apperley JF, Pavlu Jet al., 2016, Impact of Nutrition on Non-Relapse Mortality and Acute Graft Versus Host Disease during Allogeneic Hematopoietic Cell Transplantation for Hematologic Malignancies, 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Innes A, Apperley J, Allwood Z, Altaf S, Chaidos A, Kanfer E, Kirschke S, Milojkovic D, MacDonald D, Pavlu J, Rahemtulla A, Slade D, Szydlo R, Olavarria E, Gabriel Iet al., 2016, Development of acute graft-versus-host disease post allogeneic stem cell transplantation results in significant episodes of recurrent and prolonged hospitalisations which are with associated a significant economic burden to stem cell transplant units, 42nd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S575-S576, ISSN: 0268-3369

CONFERENCE PAPER

Monsalvo S, Sevillano B, Innes A, Lasa M, Skinner L, Stumpfle R, Altaf S, Yebra E, MacDonald D, Milojkovic D, Chaidos A, Gabriel IH, Brett SJ, Broomhead R, Patel P, Waheed U, Pavlu J, Palanicawandar R, Kanfer E, Szydlo RM, Apperley JF, Olavarria Eet al., 2016, The Intensive Care Trial for Critically Ill Onco-Haematologic Patients: The Need for Response Criteria at 5 Days of Full Treatment to Separate Good Risk Patients and Avoid Futile Intensive Care Interventions, 58th Annual Meeting and Exposition of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Patel A, Jhanji S, Pavlu J, Laffan M, Ethell M, Bradshaw A, Olavarria E, Harrington K, Apperley J, Brett Set al., 2016, Mesenchymal stromal stem cell (MSC) immunotherapy for experimental septic shock: systematic review and meta-analysis with trial sequential analysis of mortality, 42nd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S129-S129, ISSN: 0268-3369

CONFERENCE PAPER

Patel A, Szydlo R, Auner H, Chaidos A, Gabriel I, MacDonald D, Milojkovic D, Kanfer E, Karadimitris A, Rahemtulla A, Olavarria E, Apperley J, Pavlu Jet al., 2016, C-reactive protein (CRP) prior to myeloablative allogeneic haematopoietic stem cell transplantation is associated with early and long term survival to five years, 42nd Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S213-S214, ISSN: 0268-3369

CONFERENCE PAPER

Pavlu J, Labopin M, Tischer J, Sakellari I, Stelljes M, Finke J, Fanin R, Stuhler G, Afanasyev BV, Bloor A, Anagnostopoulos A, Mohty M, Giebel S, Nagler Aet al., 2016, Allogeneic Hematopoietic Stem Cell Transplantation for Primary Refractory Acute Lymphoblastic Leukemia - a Report from the Acute Leukemia Working Party of the EBMT, 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Pello OM, Bradshaw A, Innes A, Finn S-A, Bray E, Uddin S, Olavarria E, Apperley JF, Pavlu Jet al., 2016, Clinical Efficacy of BK Virus Specific T-Cells in Treatment of Severe Refractory Hemorrhagic Cystitis after HLA Haploidentical Transplantation, 58th Annual Meeting and Exposition of the American-Society-of-Hematology, Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Rohman PJ, Szydlo RM, Hobbs E, Palanicawandar R, Sevillano B, Monsalvo S, Innes A, Kanfer EJ, Milojkovic D, Gabriel IH, Jakob C, Macdonald D, Chaidos A, Karadimitris A, Apperley JF, Olavarria E, Pavlu Jet al., 2016, Preconditioning Neutropenia Is a Key Prognostic Factor in Allogeneic Hematopoietic Cell Transplantation for High Risk Acute Myeloid Leukemia, 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), Publisher: AMER SOC HEMATOLOGY, ISSN: 0006-4971

CONFERENCE PAPER

Bain BJ, Heller M, Toma S, Pavlu Jet al., 2015, The cytological features of NPM1-mutated acute myeloid leukemia, AMERICAN JOURNAL OF HEMATOLOGY, Vol: 90, Pages: 560-560, ISSN: 0361-8609

JOURNAL ARTICLE

Farah N, Szydlo R, Mitul P, Sridharan M, Sawhney H, Lasa M, Mccue J, Atkins M, Kanfer E, MacDonald D, Milojkovic D, Pavlu J, Olavarria E, Rahemtulla A, Chaidos A, Gabriel I, Apperley Jet al., 2015, A Study to Validate the Rationale and Efficacy of a Pre-emptive approach to the management of Cytomegalovirus (CMV) reactivation post allogeneic haematopoietic stem cell transplantation (HSCT), 41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S409-S410, ISSN: 0268-3369

CONFERENCE PAPER

Sevillano B, Pavlu J, Szydlo R, Rotolo A, Khoder A, Sever M, Lasa M, Palinacawandar R, Giles C, Chaidos A, MacDonald D, Karadimitris A, Gabriel I, Marks A, Milojkovik D, Olavarria E, Rahemtulla A, Apperley J, Kanfer Eet al., 2015, LACE-conditioned allogeneic transplantation for high-risk haematological malignancies: treatment outcomes in 62 patients from a single centre, 41st Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation, Publisher: NATURE PUBLISHING GROUP, Pages: S223-S223, ISSN: 0268-3369

CONFERENCE PAPER

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