Overview
The Pease lab are interested in all aspects of chemokine biology with the ultimate view to therapeutically target ligands and receptors in pathological settings.
Collaborators
Professor Shiranee Sriskandan, Imperial College London, Department of Medicine, SpyCEP and S. pyogenes virulence, 2010
Dr Arne Egesten, Department of Clinical Sciences, BMC B14, Tornavägen 10, SE–221 84 Lund, 2004
Dr Akos Heinemann, Department of Experimental and Clinical Pharmacology, Medical University Graz, A-8010 Graz, Austria, 2003
Guest Lectures
Cell Surface Binding of CXCL8 by Neutrophil Glycosaminoglycans Is Required for Efficient Navigation of Chemokine Gradients, Gordon Research Conference on Chemotactic Cytokines, PGA Catalunya Business and Convention Centre, Girona , Spain, 2016
Insights into biased agonist activity at chemokine receptor CCR4 by the identification of intrahelical and intracellular antagonist binding sites, First European Chemokine and Cell Migration Conference, Eurotel Victoria Villars-sur-Ollon, Switzerland, 2015
Biased Agonism at Chemokine Receptors - Challenge or Opportunity for Drug Discovery?, Gordon Research Conference on Chemotactic Cytokines, Mount Snow, West Dover, VT, USA, 2014
Natural and synthetic mutants illuminate chemokine biology., BSI Congress 2010,, Liverpool, UK., 2010
The CCR3/Eotaxin axis in asthma and allergy: lessons from small antagonists and agonists. 2009 BPS winter meeting, London, UK., BPS Winter meeting, London, UK, 2009
Molecular mechanisms underpinning the activation and antagonism of chemokine receptors., Human and viral chemokine receptors in cancer, mini symposium., Vrie Universiteit, Amsterdam, Netherlands., 2009
A sting in the tail of Serpentine Receptors, University of York. Biology Department, York, UK, 2009
Unravelling Serpentine Receptors., Animal Health Institute, Compton, UK, 2008
Unravelling Serpentine receptors., Pharmacology Department, University of Bath., Bath, UK., 2007
Walking the fine line between antagonism and agonism: small molecule antagonists and antagonists of chemokine receptors CCR1 and CCR3., Pharmacoepia Inc., Princeton, New Jersey, USA., 2007
Targeting chemokines and their receptors in allergic/respiratory inflammation., Royal Society of Medcine., London, UK., 2006
Chemokines and Their Receptors - What's the Big Attraction?, Institute for Animal Health, Compton, U.K., 2006
Chemokines and their receptors in inflammation – Bullets and targets, Royal Society of Medicine, London, UK, 2005
Assaying Chemokines and Chemotaxis, EuroSciCon, Birkbeck College, 2005
Anti-inflammatory Therapies - Chemokine Receptor Antagonists, Asthma Therapies 2004, Hilton Kensington, London, UK, 2004
Regulation of eosinophil trafficking in asthma and allergy, BIRAs Meeting, Drivers and Resolvers in Inflammation, The Barber Institute, University of Birmingham, UK, 2004
The eotaxin:CCR3 axis as a novel therapeutic target in the treatment of allergic disease., Symposium, "Immune Reactions of the Lung in Infection and Allergy” Hannover Medical School, Germany, 2004
The Molecular Biology of Chemokine Receptors., Department of Experimental and Clinical Pharmacology, University of Graz, Austria, 2003
Antagonism of the chemokine receptor CCR3 by synthetic and natural molecules, Department of Opthalmology, University College London, UK, 2002
The Molecular Biology of Chemokine Receptors : experiences with CCR3, Division of Cell and Molecular Biology, University of Reading, UK, 2002
Antagonism of Chemokine Receptors by Novel and Natural means, 5th World congress on Inflammation,, Edinburgh, U.K., 2001
Chemokine Receptor CCR3 - a novel target for future asthma therapies, Novartis Horsham Research Centre, Horsham UK, 2000
Chemokine receptors as novel therapeutic targets for the treatment of disease: Experiences with CCR3, Glaxo-Wellcome Research Centre, Stevenage, UK., 2000
Chemokine Receptors as Novel Therapeutic Targets., University of Brescia, Italy, 2000