Publications

BibTex format

@article{Gaskell:2009:10.1371/journal.pone.0004801,
author = {Gaskell, EA and Smith, JE and Pinney, JW and Westhead, DR and McConkey, GA},
doi = {10.1371/journal.pone.0004801},
journal = {PLoS One},
title = {A unique dual activity amino acid hydroxylase in Toxoplasma gondii.},
url = {http://dx.doi.org/10.1371/journal.pone.0004801},
volume = {4},
year = {2009}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The genome of the protozoan parasite Toxoplasma gondii was found to contain two genes encoding tyrosine hydroxylase; that produces L-DOPA. The encoded enzymes metabolize phenylalanine as well as tyrosine with substrate preference for tyrosine. Thus the enzymes catabolize phenylalanine to tyrosine and tyrosine to L-DOPA. The catalytic domain descriptive of this class of enzymes is conserved with the parasite enzyme and exhibits similar kinetic properties to metazoan tyrosine hydroxylases, but contains a unique N-terminal extension with a signal sequence motif. One of the genes, TgAaaH1, is constitutively expressed while the other gene, TgAaaH2, is induced during formation of the bradyzoites of the cyst stages of the life cycle. This is the first description of an aromatic amino acid hydroxylase in an apicomplexan parasite. Extensive searching of apicomplexan genome sequences revealed an ortholog in Neospora caninum but not in Eimeria, Cryptosporidium, Theileria, or Plasmodium. Possible role(s) of these bi-functional enzymes during host infection are discussed.
AU  - Gaskell,EA
AU  - Smith,JE
AU  - Pinney,JW
AU  - Westhead,DR
AU  - McConkey,GA
DO  - 10.1371/journal.pone.0004801
PY  - 2009///
TI  - A unique dual activity amino acid hydroxylase in Toxoplasma gondii.
T2  - PLoS One
UR  - http://dx.doi.org/10.1371/journal.pone.0004801
UR  - https://www.ncbi.nlm.nih.gov/pubmed/19277211
VL  - 4
ER  -

Download

DrJohnPinney

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)