Imperial College London

ProfessorJanetPowell

Faculty of MedicineDepartment of Surgery & Cancer

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 8846 7312j.powell

 
 
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Location

 

4N17Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

433 results found

Lederle FA, Powell JT, Nienaber CA, 2014, Does intensive medical treatment improve outcomes in aortic dissection?, BMJ-BRITISH MEDICAL JOURNAL, Vol: 349, ISSN: 1756-1833

Journal article

von Allmen RS, Anjum A, Powell JT, 2014, Outcomes after endovascular or open repair for degenerative descending thoracic aortic aneurysm using linked hospital data, BRITISH JOURNAL OF SURGERY, Vol: 101, Pages: 1244-1251, ISSN: 0007-1323

Journal article

Rudarakanchana N, Reeves BC, Bicknell CD, Heatley FM, Cheshire NJ, Powell JTet al., 2014, Editor's Choice - Treatment Decisions for Descending Thoracic Aneurysm: Preferences for Thoracic Endovascular Aneurysm Repair or Surveillance in a Discrete Choice Experiment, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 48, Pages: 13-22, ISSN: 1078-5884

Journal article

Doyle BJ, McGloughlin TM, Miller K, Powell JT, Norman PEet al., 2014, Regions of High Wall Stress Can Predict the Future Location of Rupture of Abdominal Aortic Aneurysm, CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, Vol: 37, Pages: 815-818, ISSN: 0174-1551

Journal article

von Allmen RS, Anjum A, Powell JT, 2014, Endovascular versus open repair for degenerative descending thoracic aortic aneurysm: Linked hospital data for England, 101st Annual Congress of the Swiss-Society-of-Surgery, Publisher: WILEY-BLACKWELL, Pages: 19-19, ISSN: 0007-1323

Conference paper

Epstein D, Sculpher MJ, Powell JT, Thompson SG, Brown LC, Greenhalgh RMet al., 2014, Long-term cost-effectiveness analysis of endovascular versus open repair for abdominal aortic aneurysm based on four randomized clinical trials, Charing Cross International Symposium, Publisher: WILEY, Pages: 623-631, ISSN: 0007-1323

Conference paper

Daugherty A, Powell JT, 2014, Recent Highlights of ATVB Aneurysms, ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Vol: 34, Pages: 691-694, ISSN: 1079-5642

Journal article

Powell JT, Hinchliffe RJ, Thompson MM, Sweeting MJ, Ashleigh R, Bell R, Gomes M, Greenhalgh RM, Grieve RJ, Heatley F, Thompson SG, Ulug Pet al., 2014, An Endovascular Strategy for Suspected Ruptured Abdominal Aortic Aneurysm Brings Earlier Home Discharge but Not Early Survival or Cost Benefits, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 47, Pages: 333-334, ISSN: 1078-5884

Journal article

von Allmen RS, Anjum A, Powell JT, 2014, Endovascular versus open repair for descending thoracic aortic aneurysm: linked hospital data for England (2006-2011), 48th Annual Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 8-8, ISSN: 0007-1323

Conference paper

Powell JT, Hinchliffe RJ, Thompson MM, Sweeting MJ, Ashleigh R, Bell R, Gomes M, Greenhalgh RM, Grieve RJ, Heatley F, Thompson SG, Ulug Pet al., 2014, Observations from the IMPROVE trial concerning the clinical care of patients with ruptured abdominal aortic aneurysm, British Journal of Surgery, Vol: 101, Pages: 216-224, ISSN: 1365-2168

Background: Single-centre series of the management of patients with ruptured abdominal aorticaneurysm (AAA) are usually too small to identify clinical factors that could improve patient outcomes.Methods: IMPROVE is a pragmatic, multicentre randomized clinical trial in which eligible patients witha clinical diagnosis of ruptured aneurysm were allocated to a strategy of endovascular aneurysm repair(EVAR) or to open repair. The influences of time and manner of hospital presentation, fluid volumestatus, type of anaesthesia, type of endovascular repair and time to aneurysm repair on 30-day mortalitywere investigated according to a prespecified plan, for the subgroup of patients with a proven diagnosisof ruptured or symptomatic AAA. Adjustment was made for potential confounding factors.Results: Some 558 of 613 randomized patients had a symptomatic or ruptured aneurysm: diagnosticaccuracy was 91·0 per cent. Patients randomized outside routine working hours had higher operativemortality (adjusted odds ratio (OR) 1·47, 95 per cent confidence interval 1·00 to 2·17). Mortality ratesafter primary and secondary presentation were similar. Lowest systolic blood pressure was stronglyand independently associated with 30-day mortality (51 per cent among those with pressure below 70mmHg). Patients who received EVAR under local anaesthesia alone had greatly reduced 30-day mortalitycompared with those who had general anaesthesia (adjusted OR 0·27, 0·10 to 0·70).Conclusion: These findings suggest that the outcome of ruptured AAA might be improved by wider useof local anaesthesia for EVAR and that a minimum blood pressure of 70 mmHg is too low a thresholdfor permissive hypotension.

Journal article

Norman PE, Powell JT, 2014, Vitamin D and Cardiovascular Disease, CIRCULATION RESEARCH, Vol: 114, Pages: 379-393, ISSN: 0009-7330

Journal article

Powell JT, Sweeting MJ, Thompson MM, Ashleigh R, Bell R, Gomes M, Greenhalgh RM, Grieve R, Heatley F, Hinchliffe RJ, Thompson SG, Ulug Pet al., 2014, Endovascular or open repair strategy for ruptured abdominal aortic aneurysm: 30 day outcomes from IMPROVE randomised trial, British Medical Journal, Vol: 348, ISSN: 1468-5833

Objective To assess whether a strategy of endovascular repair (if aortic morphology is suitable, open repair if not) versus open repair reduces early mortality for patients with suspected ruptured abdominal aortic aneurysm.Design Randomised controlled trial.Setting 30 vascular centres (29 UK, 1 Canadian), 2009-13.Participants 613 eligible patients (480 men) with a clinical diagnosis of ruptured aneurysm.Interventions 316 patients were randomised to the endovascular strategy (275 confirmed ruptures, 174 anatomically suitable for endovascular repair) and 297 to open repair (261 confirmed ruptures).Main outcome measures 30 day mortality, with 24 hour and in-hospital mortality, costs, and time and place of discharge as secondary outcomes.Results 30 day mortality was 35.4% (112/316) in the endovascular strategy group and 37.4% (111/297) in the open repair group: odds ratio 0.92 (95% confidence interval 0.66 to 1.28; P=0.62); odds ratio after adjustment for age, sex, and Hardman index 0.94 (0.67 to 1.33). Women may benefit more than men (interaction test P=0.02) from the endovascular strategy: odds ratio 0.44 (0.22 to 0.91) versus 1.18 (0.80 to 1.75). 30 day mortality for patients with confirmed rupture was 36.4% (100/275) in the endovascular strategy group and 40.6% (106/261) in the open repair group (P=0.31). More patients in the endovascular strategy than in the open repair group were discharged directly to home (189/201 (94%) v 141/183 (77%); P<0.001). Average 30 day costs were similar between the randomised groups, with an incremental cost saving for the endovascular strategy versus open repair of £1186 (€1420; $1939) (95% confidence interval −£625 to £2997).Conclusions A strategy of endovascular repair was not associated with significant reduction in either 30 day mortality or cost. Longer term cost effectiveness evaluations are needed to assess the full effects of the endovascular strategy in both men and women.

Journal article

Rudarakanchana N, Bicknell CD, Cheshire NJ, Burfitt N, Chapman A, Hamady M, Powell JTet al., 2014, Variation in Maximum Diameter Measurements of Descending Thoracic Aortic Aneurysms Using Unformatted Planes versus Images Corrected to Aortic Centerline, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 47, Pages: 19-26, ISSN: 1078-5884

Journal article

Powell JT, 2013, The Circuitous Route to Pivotal Mechanisms in Aortic Aneurysm Formation. Commentary regarding EJVES8677R, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 46, Pages: 557-557, ISSN: 1078-5884

Journal article

Bradley DT, Hughes AE, Badger SA, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Burnand K, Child AH, Clough RE, Cockerill G, Hafez H, Scott DJA, Ariens RAS, Johnson A, Sohrabi S, Smith A, Thompson MM, van Bockxmeer FM, Waltham M, Matthiasson SE, Thorleifsson G, Thorsteinsdottir U, Blankensteijn JD, Teijink JAW, Wijmenga C, de Graaf J, Kiemeney LA, Wild JB, Edkins S, Gwilliam R, Hunt SE, Potter S, Lindholt JS, Golledge J, Norman PE, van Rij A, Powell JT, Eriksson P, Stefansson K, Thompson JR, Humphries SE, Sayers RD, Deloukas P, Samani NJ, Bown MJet al., 2013, A Variant in LDLR Is Associated With Abdominal Aortic Aneurysm, CIRCULATION-CARDIOVASCULAR GENETICS, Vol: 6, Pages: 498-504, ISSN: 1942-325X

Journal article

Thompson SG, Brown LC, Sweeting MJ, Bown MJ, Kim LG, Glover MJ, Buxton MJ, Powell JTet al., 2013, Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness, HEALTH TECHNOLOGY ASSESSMENT, Vol: 17, Pages: 1-+, ISSN: 1366-5278

Journal article

Filardo G, Lederle FA, Ballard DJ, Hamilton C, da Graca B, Herrin J, Harbor J, VanBuskirk JB, Johnson GR, Powell JTet al., 2013, Immediate Open Repair vs Surveillance in Patients with Small Abdominal Aortic Aneurysms: Survival Differences by Aneurysm Size, MAYO CLINIC PROCEEDINGS, Vol: 88, Pages: 910-919, ISSN: 0025-6196

Journal article

Powell JT, Thompson SG, 2013, Should the Frequency of Surveillance for Small Abdominal Aortic Aneurysms be Reduced?, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 46, Pages: 171-172, ISSN: 1078-5884

Journal article

Jones GT, Bown MJ, Gretarsdottir S, Romaine SPR, Helgadottir A, Yu G, Tromp G, Norman PE, Jin C, Baas AF, Blankensteijn JD, Kullo IJ, Phillips LV, Williams MJA, Topless R, Merriman TR, Vasudevan TM, Lewis DR, Blair RD, Hill AA, Sayers RD, Powell JT, Deloukas P, Thorleifsson G, Matthiasson SE, Thorsteinsdottir U, Golledge J, Ariens RA, Johnson A, Sohrabi S, Scott DJ, Carey DJ, Erdman R, Elmore JR, Kuivaniemi H, Samani NJ, Stefansson K, van Rij AMet al., 2013, A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm, HUMAN MOLECULAR GENETICS, Vol: 22, Pages: 2941-2947, ISSN: 0964-6906

Journal article

von Allmen RS, Powell JT, 2013, Part Two: Against the Motion. External Diameter for AAA Size, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 46, Pages: 6-8, ISSN: 1078-5884

Journal article

Rudarakanchana N, Powell JT, 2013, Advances in Imaging and Surveillance of AAA: When, How, How Often?, PROGRESS IN CARDIOVASCULAR DISEASES, Vol: 56, Pages: 7-12, ISSN: 0033-0620

Journal article

Kitagawa A, Mastracci TM, von Allmen R, Powell JTet al., 2013, The role of diameter versus volume as the best prognostic measurement of abdominal aortic aneurysms, JOURNAL OF VASCULAR SURGERY, Vol: 58, Pages: 258-265, ISSN: 0741-5214

Journal article

Bicknell CD, Powell JT, 2013, Thoracic aortic aneurysms, BRITISH JOURNAL OF SURGERY, Vol: 100, Pages: 850-852, ISSN: 0007-1323

Journal article

Hinchliffe RJ, Ribbons T, Ulug P, Powell JTet al., 2013, Transfer of patients with ruptured abdominal aortic aneurysm from general hospitals to specialist vascular centres: results of a Delphi consensus study, EMERGENCY MEDICINE JOURNAL, Vol: 30, Pages: 483-486, ISSN: 1472-0205

Journal article

Bown MJ, Sweeting MJ, Brown LC, Powell JT, Thompson SGet al., 2013, Surveillance Intervals for Small Abdominal Aortic Aneurysms A Meta-analysis, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 309, Pages: 806-813, ISSN: 0098-7484

Journal article

von Allmen RS, Anjum A, Powell JT, 2013, Incidence of Descending Aortic Pathology and Evaluation of the Impact of Thoracic Endovascular Aortic Repair: A Population-based Study in England and Wales from 1999 to 2010, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 45, Pages: 154-159, ISSN: 1078-5884

Journal article

Hinchliffe RJ, Powell J, 2013, Re: 'Response to Letter to the Editor: Regional Disparities in Incidence, Handling and Outcomes of Patients with Symptomatic and Ruptured Abdominal Aortic Aneurysms in Norway', EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 45, Pages: 100-101, ISSN: 1078-5884

Journal article

Shalhoub J, Hinchliffe RJ, Powell JT, 2013, The World of LeGoo Assessed: A Short Systematic and Critical Review, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 45, Pages: 44-45, ISSN: 1078-5884

Journal article

Harrison SC, Smith AJP, Jones GT, Swerdlow DI, Rampuri R, Bown MJ, Folkersen L, Baas AF, de Borst GJ, Blankensteijn JD, Price JF, van der Graaf Y, McLachlan S, Agu O, Hofman A, Uitterlinden AG, Franco-Cereceda A, Ruigrok YM, van't Hof FN, Powell JT, van Rij AM, Casas JP, Eriksson P, Holmes MV, Asselbergs FW, Hingorani AD, Humphries SEet al., 2012, Interleukin-6 receptor pathways in abdominal aortic aneurysm, European Heart Journal, Vol: 34, Pages: 3707-3716, ISSN: 1522-9645

Methods We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo.Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach.Results Up to October 2011, we identified seven studies (869 cases, 851 controls). Meta-analysis demonstrated that AAA cases had higher levels of IL-6 than controls [standardized mean difference (SMD) = 0.46 SD, 95% CI = 0.25–0.66, I2 = 70%, P = 1.1 × 10–5 random effects]. Meta-analysis of five studies (4524 cases/15 710 controls) demonstrated that rs7529229 (which tags the non-synonymous variant Asp358Ala, rs2228145) was associated with a lower risk of AAA, per Ala358 allele odds ratio 0.84, 95% CI: 0.80–0.89, I2 = 0%, P = 2.7 × 10–11). In vitro analyses in lymphoblastoid cell lines demonstrated a reduction in the expression of downstream targets (STAT3, MYC and ICAM1) in response to IL-6 stimulation in Ala358 carriers.Conclusions A Mendelian randomization approach provides robust evidence that signalling via the IL-6R is likely to be a causal pathway in AAA. Drugs that inhibit IL-6R may play a role in AAA management.

Journal article

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