Imperial College London

ProfessorJanetPowell

Faculty of MedicineDepartment of Surgery & Cancer

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 8846 7312j.powell

 
 
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Location

 

4N17Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Publication Type
Year
to

433 results found

Powell JT, Epstein D, 2012, Invited commentary., J Vasc Surg, Vol: 56

Journal article

Helgadottir A, Gretarsdottir S, Thorleifsson G, Holm H, Patel RS, Gudnason T, Jones GT, van Rij AM, Eapen DJ, Baas AF, Tregouet D-A, Morange P-E, Emmerich J, Lindblad B, Gottsater A, Kiemeny LA, Lindholt JS, Sakalihasan N, Ferrell RE, Carey DJ, Elmore JR, Tsao PS, Grarup N, Jorgensen T, Witte DR, Hansen T, Pedersen O, Pola R, Gaetani E, Magnadottir HB, Wijmenga C, Tromp G, Ronkainen A, Ruigrok YM, Blankensteijn JD, Mueller T, Wells PS, Corral J, Manuel Soria J, Carlos Souto J, Peden JF, Jalilzadeh S, Mayosi BM, Keavney B, Strawbridge RJ, Sabater-Lleal M, Gertow K, Baldassarre D, Nyyssonen K, Rauramaa R, Smit AJ, Mannarino E, Giral P, Tremoli E, de Faire U, Humphries SE, Hamsten A, Haraldsdottir V, Olafsson I, Magnusson MK, Samani NJ, Levey AI, Markus HS, Kostulas K, Dichgans M, Berger K, Kuhlenbaeumer G, Ringelstein EB, Stoll M, Seedorf U, Rothwell PM, Powell JT, Kuivaniemi H, Onundarson PT, Valdimarsson E, Matthiasson SE, Gudbjartsson DF, Thorgeirsson G, Quyyumi AA, Watkins H, Farrall M, Thorsteinsdottir U, Stefansson Ket al., 2012, Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 60, Pages: 722-729, ISSN: 0735-1097

Journal article

von Allmen RS, Anjum A, Greenhalgh RM, Powell JTet al., 2012, Explaining the reduction in mortality from abdominal aortic aneurysm rupture: an analysis in England and Wales between 1996-2009, 99th Annual Congress of the Swiss-Society-of-Surgery, Publisher: WILEY-BLACKWELL, Pages: 20-20, ISSN: 0007-1323

Conference paper

Sweeting MJ, Thompson SG, Brown LC, Powell JTet al., 2012, Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms, 46th Annual Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 655-665, ISSN: 0007-1323

Conference paper

Anjum A, von Allmen R, Greenhalgh R, Powell JTet al., 2012, Explaining the decrease in mortality from abdominal aortic aneurysm rupture, BRITISH JOURNAL OF SURGERY, Vol: 99, Pages: 637-645, ISSN: 0007-1323

Journal article

von Allmen RS, Powell JT, 2012, Milestones in endovascular repair of abdominal aortic aneurysm, ITALIAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 19, Pages: 1-8, ISSN: 1824-4777

Journal article

Anjum A, von Allmen R, Greenhalgh RM, Powell JTet al., 2012, Explaining the reduction in mortality from ruptured abdominal aortic aneurysm in England and Wales 1996-2009, 46th Annual Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 10-10, ISSN: 0007-1323

Conference paper

Von Allmen RS, Powell JT, 2012, The management of ruptured abdominal aortic aneurysms: screening for abdominal aortic aneurysm and incidence of rupture, JOURNAL OF CARDIOVASCULAR SURGERY, Vol: 53, Pages: 69-76, ISSN: 0021-9509

Journal article

Brown LC, Powell JT, Thompson SG, Epstein DM, Sculpher MJ, Greenhalgh RMet al., 2012, The UK EndoVascular Aneurysm Repair (EVAR) trials: randomised trials of EVAR versus standard therapy, HEALTH TECHNOLOGY ASSESSMENT, Vol: 16, Pages: 1-+, ISSN: 1366-5278

Journal article

Anjum A, Powell JT, 2012, Is the Incidence of Abdominal Aortic Aneurysm Declining in the 21st Century? Mortality and Hospital Admissions for England & Wales and Scotland, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 43, Pages: 161-166, ISSN: 1078-5884

Journal article

Ballard DJ, Filardo G, da Graca B, Powell JTet al., 2012, Clinical practice change requires more than comparative effectiveness evidence: abdominal aortic aneurysm management in the USA, JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, Vol: 1, Pages: 31-44, ISSN: 2042-6305

Journal article

Ulug P, McCaslin JE, Stansby G, Powell JTet al., 2012, Endovascular versus conventional medical treatment for uncomplicated chronic type B aortic dissection, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

Journal article

Filardo G, Powell JT, Martinez MA-M, Ballard DJet al., 2012, Surgery for small asymptomatic abdominal aortic aneurysms, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

Journal article

Nienaber CA, Powell JT, 2012, Management of acute aortic syndromes, EUROPEAN HEART JOURNAL, Vol: 33, Pages: 26-U167, ISSN: 0195-668X

Journal article

Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA, Bradley DT, Burnand K, Child AH, Clough RE, Cockerill G, Hafez H, Scott DJA, Futers S, Johnson A, Sohrabi S, Smith A, Thompson MM, van Bockxmeer FM, Waltham M, Matthiasson SE, Thorleifsson G, Thorsteinsdottir U, Blankensteijn JD, Teijink JAW, Wijmenga C, de Graaf J, Kiemeney LA, Assimes TL, McPherson R, Folkersen L, Franco-Cereceda A, Palmen J, Smith AJ, Sylvius N, Wild JB, Refstrup M, Edkins S, Gwilliam R, Hunt SE, Potter S, Lindholt JS, Frikke-Schmidt R, Tybjaerg-Hansen A, Hughes AE, Golledge J, Norman PE, van Rij A, Powel JT, Eriksson P, Stefansson K, Thompson JR, Humphries SE, Sayers RD, Deloukas P, Samani NJet al., 2011, Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 89, Pages: 619-627, ISSN: 0002-9297

Journal article

Greenhalgh RM, Brown LC, Powell JT, Wyss TRet al., 2011, Letter to "Rate and Predictability of Graft Rupture and Open Abdominal Aortic Surgery" Reply, ANNALS OF SURGERY, Vol: 254, Pages: 834-834, ISSN: 0003-4932

Journal article

Early Breast Cancer Trialists' Collaborative Group EBCTCG, Davies C, Godwin J, Gray R, Clarke M, Cutter D, Darby S, McGale P, Pan HC, Taylor C, Wang YC, Dowsett M, Ingle J, Peto Ret al., 2011, Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials., Lancet, Vol: 378, Pages: 771-784

BACKGROUND: As trials of 5 years of tamoxifen in early breast cancer mature, the relevance of hormone receptor measurements (and other patient characteristics) to long-term outcome can be assessed increasingly reliably. We report updated meta-analyses of the trials of 5 years of adjuvant tamoxifen. METHODS: We undertook a collaborative meta-analysis of individual patient data from 20 trials (n=21,457) in early breast cancer of about 5 years of tamoxifen versus no adjuvant tamoxifen, with about 80% compliance. Recurrence and death rate ratios (RRs) were from log-rank analyses by allocated treatment. FINDINGS: In oestrogen receptor (ER)-positive disease (n=10,645), allocation to about 5 years of tamoxifen substantially reduced recurrence rates throughout the first 10 years (RR 0·53 [SE 0·03] during years 0-4 and RR 0·68 [0·06] during years 5-9 [both 2p<0·00001]; but RR 0·97 [0·10] during years 10-14, suggesting no further gain or loss after year 10). Even in marginally ER-positive disease (10-19 fmol/mg cytosol protein) the recurrence reduction was substantial (RR 0·67 [0·08]). In ER-positive disease, the RR was approximately independent of progesterone receptor status (or level), age, nodal status, or use of chemotherapy. Breast cancer mortality was reduced by about a third throughout the first 15 years (RR 0·71 [0·05] during years 0-4, 0·66 [0·05] during years 5-9, and 0·68 [0·08] during years 10-14; p<0·0001 for extra mortality reduction during each separate time period). Overall non-breast-cancer mortality was little affected, despite small absolute increases in thromboembolic and uterine cancer mortality (both only in women older than 55 years), so all-cause mortality was substantially reduced. In ER-negative disease, tamoxifen had little or no effect on breast cancer recurrence or mortality. INTERPRETATION: 5 years of adjuvant tamoxifen safely re

Journal article

Brown LC, Thompson SG, Greenhalgh RM, Powell JTet al., 2011, Incidence of cardiovascular events and death after open or endovascular repair of abdominal aortic aneurysm in the randomized EVAR trial 1, BRITISH JOURNAL OF SURGERY, Vol: 98, Pages: 935-942, ISSN: 0007-1323

Journal article

Powell JT, Sweeting MJ, Brown LC, Gotensparre SM, Fowkes FG, Thompson SGet al., 2011, Systematic review and meta-analysis of growth rates of small abdominal aortic aneurysms, BRITISH JOURNAL OF SURGERY, Vol: 98, Pages: 609-618, ISSN: 0007-1323

Journal article

Gauci BN, Powell JT, Hunt BJ, Pilcher J, Morgan R, Thompson MM, Holt PJEet al., 2011, The feasibility of catheter-directed thrombolysis for acute deep vein thrombosis: a regional perspective, PHLEBOLOGY, Vol: 26, Pages: 94-101, ISSN: 0268-3555

Journal article

Powell JT, 2011, Invited commentary., J Vasc Surg, Vol: 53

Journal article

Brown LC, Greenhalgh RM, Powell JT, Thompson SGet al., 2011, Use of baseline factors to predict complications and reinterventions after endovascular repair of abdominal aortic aneurysm (vol 97, pg 1207, 2010), BRITISH JOURNAL OF SURGERY, Vol: 98, Pages: 162-162, ISSN: 0007-1323

Journal article

Thompson M, Powell JT, 2011, Pharmacological treatment of aneurysms, Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists, Pages: 247-254, ISBN: 9780987171825

© The Contributors 2011. BACKGROUND Abdominal aortic aneurysms (AAAs) are present in 5 to 10% of men over the age of 65, and elective surgical intervention has long been the mainstay of treatment. There is widespread consensus that operative repair is the treatment of choice in larger AAAs, where the risk of rupture increases with the size of the aneurysm. However, even elective operations carry a significant mortality risk, and the UK small aneurysm trial has shown that for smaller aneurysms (between 4 and 5.5cm) there is no difference in outcome between operation and no intervention. Currently such patients are treated with best medical therapy, but there has been considerable research into finding a pharmacological treatment to prevent aneurysm expansion and rupture. SCREENING PROGRAMMES A major obstacle to the prevention of mortality and morbidity associated with aneurysms has been the fact that the majority are asymptomatic, and therefore often remain undetected. Abdominal aortic aneurysms have tended to present either as emergencies or as a result of their increasing size, and it has been shown that larger aneurysms grow more rapidly than their smaller counterparts and are at greater risk of rupture. These patients would therefore benefit most from operative repair rather than medical intervention. In order for a medical treatment to be of benefit, it needs to be targeted at aneurysms that are small and asymptomatic. The most obvious way of doing this would be the initiation of a mass screening programme, and indeed, the Multicentre Aneurysm Screening Study (MASS) has shown that as many as 88% of screen-detected aneurysms are below the threshold for surgery.

Book chapter

Powell JT, Gotensparre SM, Sweeting MJ, Brown LC, Fowkes FGR, Thompson SGet al., 2011, Rupture Rates of Small Abdominal Aortic Aneurysms: A Systematic Review of the Literature, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 41, Pages: 2-10, ISSN: 1078-5884

Journal article

Wyss TR, Brown LC, Powell JT, Greenhalgh RMet al., 2011, Rate and predictability of graft rupture after endovascular and open abdominal aortic aneurysm repair: data from the EVAR trials, 45th Annual Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 10-10, ISSN: 0007-1323

Conference paper

Moll FL, Powell JT, Fraedrich G, Verzini F, Haulon S, Waltham M, van Herwaarden JA, Holt PJE, van Keulen JW, Rantner B, Schloesser FJV, Setacci F, Rica J-Bet al., 2011, Management of Abdominal Aortic Aneurysms Clinical Practice Guidelines of the European Society for Vascular Surgery, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 41, Pages: S1-S58, ISSN: 1078-5884

Journal article

Brown LC, Greenhalgh RM, Powell JT, Thompson SGet al., 2011, Use of baseline factors to predict serious complications and re-interventions after endovascular aneurysm repair (EVAR) in patients with a large abdominal aortic aneurysm: Results from the UK EVAR trials, 45th Annual Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 7-7, ISSN: 0007-1323

Conference paper

Wyss TR, Brown LC, Powell JT, Greenhalgh RMet al., 2010, Rate and Predictability of Graft Rupture After Endovascular and Open Abdominal Aortic Aneurysm Repair Data From the EVAR Trials, ANNALS OF SURGERY, Vol: 252, Pages: 805-811, ISSN: 0003-4932

Journal article

Greenhalgh RM, Brown LC, Powell JT, 2010, The authors reply, New England Journal of Medicine, Vol: 363, Pages: 1481-1482, ISSN: 0028-4793

Journal article

Greenhalgh RM, Brown LC, Powell JT, 2010, Endovascular Repair of Abdominal Aortic Aneurysm REPLY, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 363, Pages: 1481-1482, ISSN: 0028-4793

Journal article

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