Imperial College London

ProfessorJanetPowell

Faculty of MedicineDepartment of Surgery & Cancer

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 8846 7312j.powell

 
 
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Location

 

4N17Charing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{von:2016:10.1016/j.ejvs.2016.10.025,
author = {von, Allmen RS and Gahl, B and Powell, JT},
doi = {10.1016/j.ejvs.2016.10.025},
journal = {European Journal of Vascular and Endovascular Surgery},
pages = {176--184},
title = {Editor's choice - Incidence of stroke following thoracic endovascular aortic repair for descending aortic aneurysm: a systematic review of the literature with meta-analysis.},
url = {http://dx.doi.org/10.1016/j.ejvs.2016.10.025},
volume = {53},
year = {2016}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - OBJECTIVE: Stroke is an increasingly recognised complication following thoracic endovascular aortic repair (TEVAR). The aim of this study was to systematically synthesise the published data on perioperative stroke incidence during TEVAR for patients with descending thoracic aneurysmal disease and to assess the impact of left subclavian artery (LSA) coverage on stroke incidence. METHODS: A systematic review of English and German articles on perioperative (in-hospital or 30 day) stroke incidence following TEVAR for descending aortic aneurysm was performed, including studies with ≥50 cases, using MEDLINE and EMBASE (2005-2015). The pooled prevalence of perioperative stroke with 95% CI was estimated using random effect analysis. Heterogeneity was examined using I(2) statistic. RESULTS: Of 215 studies identified, 10 were considered suitable for inclusion. The included studies enrolled a total of 2594 persons (61% male) between 1997 and 2014 with a mean weighted age of 71.8 (95% CI 71.1-73.6) years. The pooled prevalence for stroke was 4.1% (95% CI 2.9-5.5) with moderate heterogeneity between studies (I(2) = 49.8%, p = .04). Five studies reported stroke incidences stratified by the management of the LSA, that is uncovered versus covered and revascularised versus covered and not-revascularised. In cases where the LSA remained uncovered, the pooled stroke incidence was 3.2% (95% CI 1.0-6.5). There was, however, an indication that stroke incidence increased following LSA coverage, to 5.3% (95% CI 2.6-8.6) in those with a revascularisation and 8.0% (95% CI 4.1-12.9) in those without revascularisation. CONCLUSION: Stroke incidence is an important morbidity after TEVAR, and probably increases if the LSA is covered during the procedure, particularly in those without revascularisation.
AU - von,Allmen RS
AU - Gahl,B
AU - Powell,JT
DO - 10.1016/j.ejvs.2016.10.025
EP - 184
PY - 2016///
SN - 1532-2165
SP - 176
TI - Editor's choice - Incidence of stroke following thoracic endovascular aortic repair for descending aortic aneurysm: a systematic review of the literature with meta-analysis.
T2 - European Journal of Vascular and Endovascular Surgery
UR - http://dx.doi.org/10.1016/j.ejvs.2016.10.025
UR - http://www.ncbi.nlm.nih.gov/pubmed/27993454
UR - http://hdl.handle.net/10044/1/44605
VL - 53
ER -