Publications
476 results found
POWELL JT, SIAN M, WISEMAN S, et al., 1988, FIBRINOGEN AND CARBOXYHEMOGLOBIN IN PERIPHERAL ARTERIAL-DISEASE, LANCET, Vol: 1, Pages: 121-121, ISSN: 0140-6736
- Author Web Link
- Cite
- Citations: 13
Baxter K, Wiseman S, Powell JT, et al., 1988, Pilot study of a screening test for peripheral arterialdisease in middle aged men: fibrinogen as a possible risk factor, Cardiovasc Research, Vol: 22, Pages: 300-302
MENASHI S, CAMPA JS, GREENHALGH RM, et al., 1987, COLLAGEN IN ABDOMINAL AORTIC-ANEURYSM - TYPING CONTENT, AND DEGRADATION, JOURNAL OF VASCULAR SURGERY, Vol: 6, Pages: 578-582, ISSN: 0741-5214
- Author Web Link
- Cite
- Citations: 139
POWELL J, ZADEH JA, CARTER G, et al., 1987, RAISED SERUM THYROTROPIN IN WOMEN WITH PERIPHERAL ARTERIAL-DISEASE, BRITISH JOURNAL OF SURGERY, Vol: 74, Pages: 1139-1141, ISSN: 0007-1323
- Author Web Link
- Cite
- Citations: 35
WISEMAN SA, GREENHALGH RM, POWELL JT, 1987, DYSLIPOPROTEINEMIA IN FEMOROPOPLITEAL BYPASS PATIENTS, BIOCHEMICAL SOCIETY TRANSACTIONS, Vol: 15, Pages: 473-474, ISSN: 0300-5127
POWELL JT, ZADEH JA, FOWLER PBS, et al., 1987, THYROID-DYSFUNCTION IN WOMEN WITH PERIPHERAL ARTERIAL-DISEASE, BRITISH JOURNAL OF SURGERY, Vol: 74, Pages: 528-528, ISSN: 0007-1323
CAMPA JS, GREENHALGH RM, POWELL JT, 1987, CULTURE OF SMOOTH-MUSCLE CELLS FROM HUMAN AORTIC BIOPSIES, JOURNAL OF PHYSIOLOGY-LONDON, Vol: 387, Pages: P21-P21, ISSN: 0022-3751
POWELL J, GREENHALGH RM, 1987, ABDOMINAL AORTIC-ANEURYSMS, BRITISH MEDICAL JOURNAL, Vol: 294, Pages: 1161-1161, ISSN: 0959-8138
- Author Web Link
- Cite
- Citations: 3
CAMPA JS, GREENHALGH RM, POWELL JT, 1987, ELASTIN DEGRADATION IN ABDOMINAL AORTIC-ANEURYSMS, ATHEROSCLEROSIS, Vol: 65, Pages: 13-21, ISSN: 0021-9150
- Author Web Link
- Cite
- Citations: 255
Powell JT, Greenhalgh RM, 1987, Multifactorial inheritance of abdominal aortic aneurysm., Eur J Vasc Surg, Vol: 1, Pages: 29-31, ISSN: 0950-821X
The possible genetic predisposition to abdominal aortic aneurysm was investigated by recording the family history from 60 consecutive patients presenting for aneurysm repair. Twenty patients, age 63.2 +/- 9.3 years, had at least one first degree relative with abdominal aortic aneurysm. Thirty six patients, age 69.6 +/- 6.3 years, knew of no aortic aneurysm amongst first degree relatives and four patients could not give a full family history. A total of 25 among 320 first degree relatives (8%) or 14 amongst 192 siblings (7%) had an abdominal aortic aneurysm. Both the younger age of presentation (P less than 0.01) and the concentration of women amongst those with a positive family history argue for multifactorial inheritance of abdominal aortic aneurysm, with the genetic component calculated as approximately 70%. These same factors suggest that it might be worthwhile screening for aneurysmal disease the sibling smokers of female and younger male probands.
Hesselvik F, Brodin B, Von Schenck H, et al., 1987, Fibronectin depletion after aortic surgery, British Journal of Surgery, Vol: 74, Pages: 333-333, ISSN: 0007-1323
BHANDARI R, POWELL JT, 1987, A QUANTITATIVE ASSAY FOR THE ADHESION OF ALVEOLAR TYPE-II CELLS - APPLICATION TO THE STUDY OF EPITHELIAL-FIBROBLAST INTERACTIONS, EXPERIMENTAL LUNG RESEARCH, Vol: 12, Pages: 363-370, ISSN: 0190-2148
- Author Web Link
- Cite
- Citations: 5
Powell JT, Muller BR, Greenhalgh RM, 1987, Acute phase proteins in patients with abdominal aortic aneurysms, J Cardiovasc Surg, Vol: 28, Pages: 528-530
WHITNEY PL, POWELL JT, SANFORD GL, 1986, OXIDATION AND CHEMICAL MODIFICATION OF LUNG BETA-GALACTOSIDE-SPECIFIC LECTIN, BIOCHEMICAL JOURNAL, Vol: 238, Pages: 683-689, ISSN: 0264-6021
- Author Web Link
- Cite
- Citations: 84
POWELL JT, POSKITT KR, IRWIN JT, et al., 1986, OPSONIC DYSFUNCTION SECONDARY TO PLASMA FIBRONECTIN DEPLETION AFTER AORTIC-SURGERY, BRITISH JOURNAL OF SURGERY, Vol: 73, Pages: 38-40, ISSN: 0007-1323
- Author Web Link
- Cite
- Citations: 8
POWELL JT, CAMPA J, MULLER BR, et al., 1985, AORTIC-ANEURYSMS AND ALPHA-1-PROTEINASE INHIBITOR, BRITISH JOURNAL OF SURGERY, Vol: 72, Pages: 401-401, ISSN: 0007-1323
POWELL JT, 1985, CHEMICAL MODIFICATION OF ARGININE RESIDUES OF LUNG GALAPTIN AND FIBRONECTIN - EFFECTS ON FIBROBLAST BINDING, BIOCHEMICAL JOURNAL, Vol: 232, Pages: 919-922, ISSN: 0264-6021
- Author Web Link
- Cite
- Citations: 2
POWELL JT, POSKITT KR, KHONG M, et al., 1985, FIBRONECTIN DEPLETION IN ENDOTOXEMIC RABBITS, THROMBOSIS AND HAEMOSTASIS, Vol: 54, Pages: 249-249, ISSN: 0340-6245
Powell JT, 1984, Collagen glycopeptide binding proteins in developing rat lung, Federation Proceedings, Vol: 43, ISSN: 0014-9446
POWELL JT, WHITNEY PL, 1984, ENDOGENOUS LIGANDS OF RAT LUNG BETA-GALACTOSIDE-BINDING PROTEIN (GALAPTIN) ISOLATED BY AFFINITY-CHROMATOGRAPHY ON CARBOXYAMIDOMETHYLATED-GALAPTIN-SEPHAROSE, BIOCHEMICAL JOURNAL, Vol: 223, Pages: 769-774, ISSN: 0264-6021
- Author Web Link
- Cite
- Citations: 24
POWELL JT, 1984, ENDOGENOUS SUBSTRATES OF RAT LUNG GALACTOSYL SPECIFIC LECTIN, BIOLOGY OF THE CELL, Vol: 51, Pages: A56-A56, ISSN: 0248-4900
- Author Web Link
- Cite
- Citations: 1
SANFORD GL, DAVIS LD, POWELL JT, 1982, THE SUB-CELLULAR LOCALIZATION OF THE BETA-GALACTOSIDE BINDING-PROTEIN OF RAT LUNG, BIOCHEMICAL JOURNAL, Vol: 204, Pages: 97-102, ISSN: 0264-6021
- Author Web Link
- Cite
- Citations: 3
POWELL JT, WHITNEY PL, 1980, POSTNATAL-DEVELOPMENT OF RAT LUNG - CHANGES IN LUNG LECTIN, ELASTIN, ACETYLCHOLINESTERASE AND OTHER ENZYMES, BIOCHEMICAL JOURNAL, Vol: 188, Pages: 1-8, ISSN: 0264-6021
- Author Web Link
- Cite
- Citations: 113
POWELL JT, 1980, PURIFICATION AND PROPERTIES OF LUNG LECTIN - RAT LUNG AND HUMAN-LUNG BETA-GALACTOSIDE-BINDING PROTEINS, BIOCHEMICAL JOURNAL, Vol: 187, Pages: 123-129, ISSN: 0264-6021
- Author Web Link
- Cite
- Citations: 83
POWELL JT, MORRISON JF, 1979, ENZYME-ENZYME INTERACTION AND THE BIOSYNTHESIS OF AROMATIC AMINO-ACIDS IN ESCHERICHIA-COLI, BIOCHIMICA ET BIOPHYSICA ACTA, Vol: 568, Pages: 467-474, ISSN: 0006-3002
- Author Web Link
- Cite
- Citations: 12
POWELL JT, MORRISON JF, 1978, PURIFICATION AND PROPERTIES OF ASPARTATE-AMINOTRANSFERASE AND AROMATIC-AMINO-ACID AMINOTRANSFERASE FROM ESCHERICHIA-COLI, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 87, Pages: 391-400, ISSN: 0014-2956
- Author Web Link
- Cite
- Citations: 94
POWELL JT, MORRISON JF, 1978, ROLE OF ESCHERICHIA-COLI AROMATIC AMINO-ACID AMINOTRANSFERASE IN LEUCINE BIOSYNTHESIS, JOURNAL OF BACTERIOLOGY, Vol: 136, Pages: 1-4, ISSN: 0021-9193
- Author Web Link
- Cite
- Citations: 18
Powell JT, Järlfors U, Brew K, 1977, Enzymic characteristics of fat globule membranes from bovine colostrum and bovine milk, Journal of Cell Biology, Vol: 72, Pages: 617-627, ISSN: 1540-8140
Fat globule membranes have been isolated from bovine colostrum and bovine milk by the dispersion of the fat in sucrose solutions at 4 degrees C and fractionation by centrifugation through discontinuous sucrose gradients. The morphology and enzymic characteristics of the separated fractions were examined. Fractions comprising a large proportion of the total extracted membrane were thus obtained having high levels of the Golgi marker enzymes UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase and thiamine pyrophosphatase. A membrane-derived form of the galactosyltransferase has been solubilized from fat and purified to homogeneity. This enzyme is larger in molecular weight than previously studied soluble galactosyltransferases, but resembles in size the galactosyltransferase of lactating mammary Golgi membranes. In contrast, when fat globule membranes were prepared by traditional procedures, which involved washing the fat at higher temperatures, before extraction, galactosyltransferase was not present in the membranes, having been released into supernatant fractions, When the enzyme released by this procedure was partially purified and examined by gel filtration, it was found to be of a degraded form resembling in size the soluble galactosyltransferase of milk. The release is therefore attributed to the action of proteolytic enzymes. Our observations contrast with previous biochemical studies which suggested that Golgi membranes do not contribute to the milk fat globule membrane. They are, however, consistent with electron microscope studies of the fat secretion process, which indicate that secretory vesicle membranes, derived from the Golgi apparatus, may provide a large proportion of the fat globule membrane.
Powell JT, Brew K, 1976, Affinity labeling of bovine colostrum galactosyltransferase with a uridine 5'-diphosphate derivative., Biochemistry, Vol: 15, Pages: 3499-3505, ISSN: 0006-2960
The dialdehyde produced by the periodate cleavage of the ribose moiety of uridine 5'-diphosphate (UDP) has been used as an affinity label for the UDP-galactose/UDP binding site of galactosyltransferase from bovine colostrum. This derivative causes progressive inactivation of galactosyltransferase at a rate dependent on its concentration, and under certain conditions is a competitive inhibitor with respect to UDP-galactose. The substrate UDP-galactose protects the enzyme from inactivation. The inactivation is also dependent on Mn2+ concentration in a range that implies that the binding of Mn2+ at site I is a prerequisite for the binding of the UDP derivative. The inactivation can be progressively reversed by nitrogenous bases, or stabilized by KBH4 reduction, which is consistent with the hypothesis that a Schiff base has formed with a lysine residue. Galactosyltransferase was inactivated with a [3H]UDP derivative and the predominant labeled peptide, from thermolysin digestion, isolated and characterized as: Ser-Gly-Lys-UDP.
SEBER JF, TOOMEY TP, POWELL JT, et al., 1976, PROTEOLYTIC-ENZYMES OF K-1 STRAIN OF STREPTOMYCES-GRISEUS OBTAINED FROM A COMMERCIAL PREPARATION (PRONASE) - PURIFICATION AND CHARACTERIZATION OF CARBOXYPEPTIDASE, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 251, Pages: 204-208, ISSN: 0021-9258
- Author Web Link
- Cite
- Citations: 19
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.