Imperial College London
Portrait Picture

ProfessorJanetPowell

Faculty of Medicine, Department of Surgery & Cancer

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 3311 7312j.powell

 
 
//

Location

 

4E05Charing Cross HospitalCharing Cross Campus

//

Summary

 

Publications

Publication Type
Year
to

476 results found

Kitagawa A, Mastracci TM, von Allmen R, Powell JTet al., 2013, The role of diameter versus volume as the best prognostic measurement of abdominal aortic aneurysms, JOURNAL OF VASCULAR SURGERY, Vol: 58, Pages: 258-265, ISSN: 0741-5214

Journal article

von Allmen RS, Powell JT, 2013, Part Two: Against the Motion. External Diameter for AAA Size, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 46, Pages: 6-8, ISSN: 1078-5884

Journal article

Bicknell CD, Powell JT, 2013, Thoracic aortic aneurysms, BRITISH JOURNAL OF SURGERY, Vol: 100, Pages: 850-852, ISSN: 0007-1323

Journal article

Hinchliffe RJ, Ribbons T, Ulug P, Powell JTet al., 2013, Transfer of patients with ruptured abdominal aortic aneurysm from general hospitals to specialist vascular centres: results of a Delphi consensus study, EMERGENCY MEDICINE JOURNAL, Vol: 30, Pages: 483-486, ISSN: 1472-0205

Journal article

Bown MJ, Sweeting MJ, Brown LC, Powell JT, Thompson SGet al., 2013, Surveillance Intervals for Small Abdominal Aortic Aneurysms A Meta-analysis, JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, Vol: 309, Pages: 806-813, ISSN: 0098-7484

Journal article

von Allmen RS, Anjum A, Powell JT, 2013, Incidence of Descending Aortic Pathology and Evaluation of the Impact of Thoracic Endovascular Aortic Repair: A Population-based Study in England and Wales from 1999 to 2010, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 45, Pages: 154-159, ISSN: 1078-5884

Journal article

Hinchliffe RJ, Powell J, 2013, Re: 'Response to Letter to the Editor: Regional Disparities in Incidence, Handling and Outcomes of Patients with Symptomatic and Ruptured Abdominal Aortic Aneurysms in Norway', EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 45, Pages: 100-101, ISSN: 1078-5884

Journal article

Hinchliffe RJ, Powell J, 2013, Re: 'Response to letter to the editor: Regional disparities in incidence, handling and outcomes of patients with symptomatic and ruptured abdominal aortic aneurysms in Norway'., Eur J Vasc Endovasc Surg, Vol: 45, Pages: 100-101

Journal article

Shalhoub J, Hinchliffe RJ, Powell JT, 2013, The World of LeGoo Assessed: A Short Systematic and Critical Review, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 45, Pages: 44-45, ISSN: 1078-5884

Journal article

Harrison SC, Smith AJP, Jones GT, Swerdlow DI, Rampuri R, Bown MJ, Folkersen L, Baas AF, de Borst GJ, Blankensteijn JD, Price JF, van der Graaf Y, McLachlan S, Agu O, Hofman A, Uitterlinden AG, Franco-Cereceda A, Ruigrok YM, van't Hof FN, Powell JT, van Rij AM, Casas JP, Eriksson P, Holmes MV, Asselbergs FW, Hingorani AD, Humphries SEet al., 2012, Interleukin-6 receptor pathways in abdominal aortic aneurysm, European Heart Journal, Vol: 34, Pages: 3707-3716, ISSN: 1522-9645

Methods We conducted a systematic review and meta-analysis of studies reporting circulating IL-6 in AAA, and new investigations of the association between a common non-synonymous functional variant (Asp358Ala) in the IL-6R gene (IL6R) and AAA, followed the analysis of the variant both in vitro and in vivo.Inflammation may play a role in the development of abdominal aortic aneurysms (AAA). Interleukin-6 (IL-6) signalling through its receptor (IL-6R) is one pathway that could be exploited pharmacologically. We investigated this using a Mendelian randomization approach.Results Up to October 2011, we identified seven studies (869 cases, 851 controls). Meta-analysis demonstrated that AAA cases had higher levels of IL-6 than controls [standardized mean difference (SMD) = 0.46 SD, 95% CI = 0.25–0.66, I2 = 70%, P = 1.1 × 10–5 random effects]. Meta-analysis of five studies (4524 cases/15 710 controls) demonstrated that rs7529229 (which tags the non-synonymous variant Asp358Ala, rs2228145) was associated with a lower risk of AAA, per Ala358 allele odds ratio 0.84, 95% CI: 0.80–0.89, I2 = 0%, P = 2.7 × 10–11). In vitro analyses in lymphoblastoid cell lines demonstrated a reduction in the expression of downstream targets (STAT3, MYC and ICAM1) in response to IL-6 stimulation in Ala358 carriers.Conclusions A Mendelian randomization approach provides robust evidence that signalling via the IL-6R is likely to be a causal pathway in AAA. Drugs that inhibit IL-6R may play a role in AAA management.

Journal article

Powell JT, Epstein D, 2012, Invited commentary., J Vasc Surg, Vol: 56

Journal article

Helgadottir A, Gretarsdottir S, Thorleifsson G, Holm H, Patel RS, Gudnason T, Jones GT, van Rij AM, Eapen DJ, Baas AF, Tregouet D-A, Morange P-E, Emmerich J, Lindblad B, Gottsater A, Kiemeny LA, Lindholt JS, Sakalihasan N, Ferrell RE, Carey DJ, Elmore JR, Tsao PS, Grarup N, Jorgensen T, Witte DR, Hansen T, Pedersen O, Pola R, Gaetani E, Magnadottir HB, Wijmenga C, Tromp G, Ronkainen A, Ruigrok YM, Blankensteijn JD, Mueller T, Wells PS, Corral J, Manuel Soria J, Carlos Souto J, Peden JF, Jalilzadeh S, Mayosi BM, Keavney B, Strawbridge RJ, Sabater-Lleal M, Gertow K, Baldassarre D, Nyyssonen K, Rauramaa R, Smit AJ, Mannarino E, Giral P, Tremoli E, de Faire U, Humphries SE, Hamsten A, Haraldsdottir V, Olafsson I, Magnusson MK, Samani NJ, Levey AI, Markus HS, Kostulas K, Dichgans M, Berger K, Kuhlenbaeumer G, Ringelstein EB, Stoll M, Seedorf U, Rothwell PM, Powell JT, Kuivaniemi H, Onundarson PT, Valdimarsson E, Matthiasson SE, Gudbjartsson DF, Thorgeirsson G, Quyyumi AA, Watkins H, Farrall M, Thorsteinsdottir U, Stefansson Ket al., 2012, Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Vol: 60, Pages: 722-729, ISSN: 0735-1097

Journal article

von Allmen RS, Anjum A, Greenhalgh RM, Powell JTet al., 2012, Explaining the reduction in mortality from abdominal aortic aneurysm rupture: an analysis in England and Wales between 1996-2009, 99th Annual Congress of the Swiss-Society-of-Surgery, Publisher: WILEY-BLACKWELL, Pages: 20-20, ISSN: 0007-1323

Conference paper

Sweeting MJ, Thompson SG, Brown LC, Powell JTet al., 2012, Meta-analysis of individual patient data to examine factors affecting growth and rupture of small abdominal aortic aneurysms, 46th Annual General Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland, Publisher: OXFORD UNIV PRESS, Pages: 655-665, ISSN: 0007-1323

Conference paper

Anjum A, von Allmen R, Greenhalgh R, Powell JTet al., 2012, Explaining the decrease in mortality from abdominal aortic aneurysm rupture, BRITISH JOURNAL OF SURGERY, Vol: 99, Pages: 637-645, ISSN: 0007-1323

Journal article

von Allmen RS, Powell JT, 2012, Milestones in endovascular repair of abdominal aortic aneurysm, ITALIAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 19, Pages: 1-8, ISSN: 1824-4777

Journal article

Anjum A, von Allmen R, Greenhalgh RM, Powell JTet al., 2012, Explaining the reduction in mortality from ruptured abdominal aortic aneurysm in England and Wales 1996-2009, 46th Annual Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 10-10, ISSN: 0007-1323

Conference paper

Von Allmen RS, Powell JT, 2012, The management of ruptured abdominal aortic aneurysms: screening for abdominal aortic aneurysm and incidence of rupture, JOURNAL OF CARDIOVASCULAR SURGERY, Vol: 53, Pages: 69-76, ISSN: 0021-9509

Journal article

Brown LC, Powell JT, Thompson SG, Epstein DM, Sculpher MJ, Greenhalgh RMet al., 2012, The UK EndoVascular Aneurysm Repair (EVAR) trials: randomised trials of EVAR versus standard therapy, HEALTH TECHNOLOGY ASSESSMENT, Vol: 16, Pages: 1-+, ISSN: 1366-5278

Journal article

Anjum A, Powell JT, 2012, Is the Incidence of Abdominal Aortic Aneurysm Declining in the 21st Century? Mortality and Hospital Admissions for England & Wales and Scotland, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 43, Pages: 161-166, ISSN: 1078-5884

Journal article

Ballard DJ, Filardo G, da Graca B, Powell JTet al., 2012, Clinical practice change requires more than comparative effectiveness evidence: abdominal aortic aneurysm management in the USA, JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH, Vol: 1, Pages: 31-44, ISSN: 2042-6305

Journal article

Nienaber CA, Powell JT, 2012, Management of acute aortic syndromes, EUROPEAN HEART JOURNAL, Vol: 33, Pages: 26-U167, ISSN: 0195-668X

Journal article

Ulug P, McCaslin JE, Stansby G, Powell JTet al., 2012, Endovascular versus conventional medical treatment for uncomplicated chronic type B aortic dissection, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

Journal article

Filardo G, Powell JT, Martinez MA-M, Ballard DJet al., 2012, Surgery for small asymptomatic abdominal aortic aneurysms, COCHRANE DATABASE OF SYSTEMATIC REVIEWS, ISSN: 1469-493X

Journal article

Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA, Bradley DT, Burnand K, Child AH, Clough RE, Cockerill G, Hafez H, Scott DJA, Futers S, Johnson A, Sohrabi S, Smith A, Thompson MM, van Bockxmeer FM, Waltham M, Matthiasson SE, Thorleifsson G, Thorsteinsdottir U, Blankensteijn JD, Teijink JAW, Wijmenga C, de Graaf J, Kiemeney LA, Assimes TL, McPherson R, Folkersen L, Franco-Cereceda A, Palmen J, Smith AJ, Sylvius N, Wild JB, Refstrup M, Edkins S, Gwilliam R, Hunt SE, Potter S, Lindholt JS, Frikke-Schmidt R, Tybjaerg-Hansen A, Hughes AE, Golledge J, Norman PE, van Rij A, Powel JT, Eriksson P, Stefansson K, Thompson JR, Humphries SE, Sayers RD, Deloukas P, Samani NJet al., 2011, Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1, AMERICAN JOURNAL OF HUMAN GENETICS, Vol: 89, Pages: 619-627, ISSN: 0002-9297

Journal article

Greenhalgh RM, Brown LC, Powell JT, Wyss TRet al., 2011, Letter to "Rate and Predictability of Graft Rupture and Open Abdominal Aortic Surgery" <i>Reply</i>, ANNALS OF SURGERY, Vol: 254, Pages: 834-834, ISSN: 0003-4932

Journal article

Davies C, Godwin J, Gray R, Clarke M, Darby S, McGale P, Wang YC, Peto R, Pan HC, Cutter D, Taylor C, Ingle Jet al., 2011, Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials, LANCET, Vol: 378, Pages: 771-784, ISSN: 0140-6736

Journal article

Brown LC, Thompson SG, Greenhalgh RM, Powell JTet al., 2011, Incidence of cardiovascular events and death after open or endovascular repair of abdominal aortic aneurysm in the randomized EVAR trial 1, BRITISH JOURNAL OF SURGERY, Vol: 98, Pages: 935-942, ISSN: 0007-1323

Journal article

Powell JT, Sweeting MJ, Brown LC, Gotensparre SM, Fowkes FG, Thompson SGet al., 2011, Systematic review and meta-analysis of growth rates of small abdominal aortic aneurysms, BRITISH JOURNAL OF SURGERY, Vol: 98, Pages: 609-618, ISSN: 0007-1323

Journal article

Gauci BN, Powell JT, Hunt BJ, Pilcher J, Morgan R, Thompson MM, Holt PJEet al., 2011, The feasibility of catheter-directed thrombolysis for acute deep vein thrombosis: a regional perspective, PHLEBOLOGY, Vol: 26, Pages: 94-101, ISSN: 0268-3555

Journal article

This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.

Request URL: http://wlsprd.imperial.ac.uk:80/respub/WEB-INF/jsp/search-html.jsp Request URI: /respub/WEB-INF/jsp/search-html.jsp Query String: id=00165396&limit=30&person=true&page=5&respub-action=search.html