Publications
476 results found
Thompson M, Powell JT, 2011, Pharmacological treatment of aneurysms, Mechanisms of Vascular Disease: A Reference Book for Vascular Specialists, Pages: 247-254, ISBN: 9780987171825
BACKGROUND Abdominal aortic aneurysms (AAAs) are present in 5 to 10% of men over the age of 65, and elective surgical intervention has long been the mainstay of treatment. There is widespread consensus that operative repair is the treatment of choice in larger AAAs, where the risk of rupture increases with the size of the aneurysm. However, even elective operations carry a significant mortality risk, and the UK small aneurysm trial has shown that for smaller aneurysms (between 4 and 5.5cm) there is no difference in outcome between operation and no intervention. Currently such patients are treated with best medical therapy, but there has been considerable research into finding a pharmacological treatment to prevent aneurysm expansion and rupture. SCREENING PROGRAMMES A major obstacle to the prevention of mortality and morbidity associated with aneurysms has been the fact that the majority are asymptomatic, and therefore often remain undetected. Abdominal aortic aneurysms have tended to present either as emergencies or as a result of their increasing size, and it has been shown that larger aneurysms grow more rapidly than their smaller counterparts and are at greater risk of rupture. These patients would therefore benefit most from operative repair rather than medical intervention. In order for a medical treatment to be of benefit, it needs to be targeted at aneurysms that are small and asymptomatic. The most obvious way of doing this would be the initiation of a mass screening programme, and indeed, the Multicentre Aneurysm Screening Study (MASS) has shown that as many as 88% of screen-detected aneurysms are below the threshold for surgery.
Brown LC, Greenhalgh RM, Powell JT, et al., 2011, Use of baseline factors to predict complications and reinterventions after endovascular repair of abdominal aortic aneurysm (vol 97, pg 1207, 2010), BRITISH JOURNAL OF SURGERY, Vol: 98, Pages: 162-162, ISSN: 0007-1323
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- Citations: 3
Powell JT, Gotensparre SM, Sweeting MJ, et al., 2011, Rupture Rates of Small Abdominal Aortic Aneurysms: A Systematic Review of the Literature, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 41, Pages: 2-10, ISSN: 1078-5884
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- Citations: 46
Wyss TR, Brown LC, Powell JT, et al., 2011, Rate and predictability of graft rupture after endovascular and open abdominal aortic aneurysm repair: data from the EVAR trials, 45th Annual Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 10-10, ISSN: 0007-1323
Moll FL, Powell JT, Fraedrich G, et al., 2011, Management of Abdominal Aortic Aneurysms Clinical Practice Guidelines of the European Society for Vascular Surgery, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 41, Pages: S1-S58, ISSN: 1078-5884
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- Citations: 1139
Brown LC, Greenhalgh RM, Powell JT, et al., 2011, Use of baseline factors to predict serious complications and re-interventions after endovascular aneurysm repair (EVAR) in patients with a large abdominal aortic aneurysm: Results from the UK EVAR trials, 45th Annual Scientific Meeting of the Vascular-Society-of-Great-Britain-and-Ireland, Publisher: WILEY-BLACKWELL, Pages: 7-7, ISSN: 0007-1323
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- Citations: 1
Wyss TR, Brown LC, Powell JT, et al., 2010, Rate and Predictability of Graft Rupture After Endovascular and Open Abdominal Aortic Aneurysm Repair <i>Data From the EVAR Trials</i>, ANNALS OF SURGERY, Vol: 252, Pages: 805-811, ISSN: 0003-4932
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- Citations: 164
Greenhalgh RM, Brown LC, Powell JT, 2010, The authors reply, New England Journal of Medicine, Vol: 363, Pages: 1481-1482, ISSN: 0028-4793
Greenhalgh RM, Brown LC, Powell JT, 2010, Endovascular Repair of Abdominal Aortic Aneurysm REPLY, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 363, Pages: 1481-1482, ISSN: 0028-4793
Powell JT, Hinchliffe RJ, 2010, Part One: For the Motion A randomised controlled trial is the best way to determine whether endovascular repair is the preferred management strategy in patients with a ruptured aortic aneurysm, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 40, Pages: 421-424, ISSN: 1078-5884
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- Citations: 2
Veith FJ, Powell JT, Hinchliffe RJ, 2010, Is a randomized trial necessary to determine whether endovascular repair is the preferred management strategy in patients with ruptured abdominal aortic aneurysms?, JOURNAL OF VASCULAR SURGERY, Vol: 52, Pages: 1087-1093, ISSN: 0741-5214
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- Citations: 20
Greenhalgh RM, Brown LC, Powell JT, et al., 2010, Long-term Results Of Endovascular Aneurysm Repair (EVAR) Versus Open Repair In Patients With Large Abdominal Aortic Aneurysm: Results Of The UK EVAR Trial 1, 22nd Annual Transcatheter Cardiovascular Therapeutics (TCT) Symposium, Publisher: ELSEVIER SCIENCE INC, Pages: B92-B92, ISSN: 0735-1097
Greenhalgh RM, Brown LC, Powell JT, et al., 2010, Long-term Results Of Endovascular Aneurysm Repair (EVAR) In Patients Considered Unfit For Open Repair: Results Of The UK EVAR Trial 2, 22nd Annual Transcatheter Cardiovascular Therapeutics (TCT) Symposium, Publisher: ELSEVIER SCIENCE INC, Pages: B92-B92, ISSN: 0735-1097
Liapis CD, Bell PF, Mikhailidis DP, et al., 2010, ESVS Guidelines: Section B - Diagnosis and Investigation of Patients with Carotid Stenosis, CURRENT VASCULAR PHARMACOLOGY, Vol: 8, Pages: 682-691, ISSN: 1570-1611
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- Citations: 16
Brown LC, Greenhalgh RM, Powell JT, et al., 2010, Use of baseline factors to predict complications and reinterventions after endovascular repair of abdominal aortic aneurysm, BRITISH JOURNAL OF SURGERY, Vol: 97, Pages: 1207-1217, ISSN: 0007-1323
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- Citations: 73
Gretarsdottir S, Baas AF, Thorleifsson G, et al., 2010, Genome-wide association study identifies a sequence variant within the <i>DAB2IP</i> gene conferring susceptibility to abdominal aortic aneurysm, NATURE GENETICS, Vol: 42, Pages: 692-U71, ISSN: 1061-4036
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- Citations: 146
Sweeting MJ, Thompson SG, Brown LC, et al., 2010, Use of angiotensin converting enzyme inhibitors is associated with increased growth rate of abdominal aortic aneurysms, JOURNAL OF VASCULAR SURGERY, Vol: 52, Pages: 1-4, ISSN: 0741-5214
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- Citations: 114
Powell JT, Brown LC, 2010, The Long-term Results of the UK EVAR Trials: The Sting in the Tail, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 40, Pages: 44-46, ISSN: 1078-5884
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- Citations: 10
Powell JT, Thompson MM, Thompson SG, et al., 2010, Getting research in the NHS started, LANCET, Vol: 375, Pages: 2072-2072, ISSN: 0140-6736
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- Citations: 1
Greenhalgh RM, Brown LC, Powell JT, et al., 2010, Endovascular versus Open Repair of Abdominal Aortic Aneurysm, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 362, Pages: 1863-1871, ISSN: 0028-4793
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- Citations: 1073
Greenhalgh RM, Brown LC, Powell JT, et al., 2010, Endovascular Repair of Aortic Aneurysm in Patients Physically Ineligible for Open Repair, NEW ENGLAND JOURNAL OF MEDICINE, Vol: 362, Pages: 1872-1880, ISSN: 0028-4793
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- Citations: 221
Brown LC, Brown EA, Greenhalgh RM, et al., 2010, Renal Function and Abdominal Aortic Aneurysm (AAA) <i>The Impact of Different Management Strategies on Long</i>-<i>Term Renal Function in the UK EndoVascular Aneurysm Repair</i> (<i>EVAR</i>) <i>Trials</i>, ANNALS OF SURGERY, Vol: 251, Pages: 966-975, ISSN: 0003-4932
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- Citations: 56
Brown LC, Greenhalgh RM, Thompson SG, et al., 2010, Does EVAR Alter the Rate of Cardiovascular Events in Patients with Abdominal Aortic Aneurysm Considered Unfit for Open Repair? Results from the Randomised EVAR Trial 2, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 39, Pages: 396-402, ISSN: 1078-5884
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- Citations: 25
Norman PE, Powell JT, 2010, Site Specificity of Aneurysmal Disease, CIRCULATION, Vol: 121, Pages: 560-568, ISSN: 0009-7322
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- Citations: 101
Reise JA, Sheldon H, Earnshaw J, et al., 2010, Patient Preference for Surgical Method of Abdominal Aortic Aneurysm Repair: Postal Survey, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 39, Pages: 55-61, ISSN: 1078-5884
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- Citations: 50
Powell JT, 2010, AGAINST THE MOTION, CONTROVERSIES AND UPDATES IN VASCULAR SURGERY 2010, Editors: Becquemin, Alimi, Gerard, Publisher: EDIZIONI MINERVA MEDICA, Pages: 263-266, ISBN: 978-88-7711-663-5
Early Breast Cancer Trialists' Collaborative Group EBCTCG, Correa C, McGale P, et al., 2010, Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast., J Natl Cancer Inst Monogr, Vol: 2010, Pages: 162-177
Individual patient data were available for all four of the randomized trials that began before 1995, and that compared adjuvant radiotherapy vs no radiotherapy following breast-conserving surgery for ductal carcinoma in situ (DCIS). A total of 3729 women were eligible for analysis. Radiotherapy reduced the absolute 10-year risk of any ipsilateral breast event (ie, either recurrent DCIS or invasive cancer) by 15.2% (SE 1.6%, 12.9% vs 28.1% 2 P <.00001), and it was effective regardless of the age at diagnosis, extent of breast-conserving surgery, use of tamoxifen, method of DCIS detection, margin status, focality, grade, comedonecrosis, architecture, or tumor size. The proportional reduction in ipsilateral breast events was greater in older than in younger women (2P < .0004 for difference between proportional reductions; 10-year absolute risks: 18.5% vs 29.1% at ages <50 years, 10.8% vs 27.8% at ages ≥ 50 years) but did not differ significantly according to any other available factor. Even for women with negative margins and small low-grade tumors, the absolute reduction in the 10-year risk of ipsilateral breast events was 18.0% (SE 5.5, 12.1% vs 30.1%, 2P = .002). After 10 years of follow-up, there was, however, no significant effect on breast cancer mortality, mortality from causes other than breast cancer, or all-cause mortality.
Powell JT, 2009, Time to IMPROVE the Management of Ruptured Abdominal Aortic Aneurysm: IMPROVE Trialists, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 38, Pages: 237-238, ISSN: 1078-5884
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- Citations: 25
Powell JT, Golledge J, 2009, The Integration of Vascular Biology and Vascular Disease Diagnosis and Intervention, EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY, Vol: 37, Pages: 712-713, ISSN: 1078-5884
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