Imperial College London
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ProfessorJenniferQuint

Faculty of Medicine, School of Public Health

Professor of Respiratory Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 8821j.quint

 
 
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Location

 

.922Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Whittaker:2019:10.1186/s12931-019-1249-x,
author = {Whittaker, H and Jarvis, D and Sheikh, M and Kiddle, S and Quint, J},
doi = {10.1186/s12931-019-1249-x},
journal = {Respiratory Research},
title = {Inhaled corticosteroids and FEV decline in chronic obstructive pulmonary disease: a systematic review},
url = {http://dx.doi.org/10.1186/s12931-019-1249-x},
volume = {20},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rate of FEV1 decline in COPD is heterogeneous and the extent to which inhaled corticosteroids (ICS) influence the rate of decline is unclear. The majority of previous reviews have investigated specific ICS and non-ICS inhalers and have consisted of randomised control trials (RCTs), which have specific inclusion and exclusion criteria and short follow up times. We aimed to investigate the association between change in FEV1 and ICS-containing medications in COPD patients over longer follow up times.MEDLINE and EMBASE were searched and literature comparing change in FEV1 in COPD patients taking ICS-containing medications with patients taking non-ICS-containing medications were identified. Titles, abstract, and full texts were screened and information extracted using the PICO checklist. Risk of bias was assessed using the Cochrane Risk of Bias tool and a descriptive synthesis of the literature was carried out due to the heterogeneity of included studies. 17 studies met our inclusion criteria. We found that the difference in change in FEV1 in people using ICS and non-ICS containing medications depended on the study follow-up time.  Shorter follow-up studies (1 year or less) were more likely to report an increase in FEV1 from baseline in both patients on ICS and in patients on non-ICS-containing medications, with the majority of these studies showing a greater increase in FEV1 in patients on ICS-containing medications. Longer follow-up studies (greater than 1 year) were more likely to report a decline in FEV1 from baseline in patients on ICS and in patients on non-ICS containing medications but differences between rates of FEV1 of decline were not significant.  Further studies are needed to better understand changes in FEV1 when ICS-containing medications are prescribed and to determine whether ICS-containing medications influence rate of decline in FEV1 in the long term. Results from inclusive trials and observational patient cohorts may provide information more generali
AU  - Whittaker,H
AU  - Jarvis,D
AU  - Sheikh,M
AU  - Kiddle,S
AU  - Quint,J
DO  - 10.1186/s12931-019-1249-x
PY  - 2019///
SN  - 1465-9921
TI  - Inhaled corticosteroids and FEV decline in chronic obstructive pulmonary disease: a systematic review
T2  - Respiratory Research
UR  - http://dx.doi.org/10.1186/s12931-019-1249-x
UR  - http://hdl.handle.net/10044/1/75328
VL  - 20
ER  -
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