Imperial College London
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ProfessorJenniferQuint

Faculty of Medicine, School of Public Health

Professor of Respiratory Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 8821j.quint

 
 
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Location

 

.922Sir Michael Uren HubWhite City Campus

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Summary

 

Publications

Citation

BibTex format

@article{Axson:2020:10.1513/AnnalsATS.201911-820OC,
author = {Axson, E and Sundaram, V and Bloom, C and Bottle, R and Cowie, M and Quint, J},
doi = {10.1513/AnnalsATS.201911-820OC},
journal = {Annals of the American Thoracic Society},
pages = {939--948},
title = {Temporal trends in the incidence of heart failure among patients with COPD and its association with mortality},
url = {http://dx.doi.org/10.1513/AnnalsATS.201911-820OC},
volume = {17},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rationale: Heart failure (HF) is a common comorbidity in the chronic obstructive pulmonary disease (COPD) population, but previous research has shown under recognition. Objectives: To determine the incidence of HF in a prevalent COPD cohort. To determine the association of incident HF with short- and long-term mortality of patients with COPD. Methods: Crude incidence of HF in the HF-naïve primary care COPD population was calculated for each year from 2006-2016 using UK data from the Clinical Practice Research Datalink (CPRD). Patients with COPD were identified using a validated code list and were required to be over 35 years old at COPD diagnosis, have a history of smoking, and have documented airflow obstruction. Office of National Statistics provided mortality data for England. Adjusted mortality rate ratios (aMRR) from Poisson regression were calculated for patients with COPD and incident HF (COPD-iHF) in 2006, 2011, and 2015 and compared temporally with patients with COPD and without incident HF (COPD-no HF) in those years. Regression was adjusted for age, sex, BMI, severity of airflow limitation, smoking status, history of cardiovascular disease, and diabetes. Results: We identified 95,987 HF-naïve patients with COPD. Crude incidence of HF was steady from 2006-2016 (1.18 per 100 person-years (95%CI: 1.09, 1.27)). Patients with COPD-iHF experienced greater than threefold increase in one-year mortality and twofold increase in five-year and 10-year mortality compared with patients with COPD-no HF, with no change based on year of HF diagnosis. Mortality of patients with COPD-iHF did not improve over time, comparing incident HF in 2011 (1-year aMRR 1.26, 95%CI: 0.83, 1.90; 5-year aMRR 1.26, 95%CI: 0.98, 1.61) and 2015 (1-year aMRR 1.63, 95%CI: 0.98, 2.70) with incident HF in 2006. Conclusions: The incidence of HF in the UK COPD population was stable in the last decade. Survival of patients with COPD and incident HF has not improved over time in England. Be
AU  - Axson,E
AU  - Sundaram,V
AU  - Bloom,C
AU  - Bottle,R
AU  - Cowie,M
AU  - Quint,J
DO  - 10.1513/AnnalsATS.201911-820OC
EP  - 948
PY  - 2020///
SN  - 1546-3222
SP  - 939
TI  - Temporal trends in the incidence of heart failure among patients with COPD and its association with mortality
T2  - Annals of the American Thoracic Society
UR  - http://dx.doi.org/10.1513/AnnalsATS.201911-820OC
UR  - https://www.atsjournals.org/doi/10.1513/AnnalsATS.201911-820OC
UR  - http://hdl.handle.net/10044/1/79051
VL  - 17
ER  -
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