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@article{Taquet:2023:10.1038/s41591-023-02525-y,
author = {Taquet, M and Skorniewska, Z and Hampshire, A and Chalmers, JD and Ho, L-P and Horsley, A and Marks, M and Poinasamy, K and Raman, B and Leavy, OC and Richardson, M and Elneima, O and McAuley, HJC and Shikotra, A and Singapuri, A and Sereno, M and Saunders, RM and Harris, VC and Houchen-Wolloff, L and Greening, NJ and Mansoori, P and Harrison, EM and Docherty, AB and Lone, NI and Quint, J and Sattar, N and Brightling, CE and Wain, LV and Evans, RE and Geddes, JR and Harrison, PJ and PHOSP-COVID, Study Collaborative Group},
doi = {10.1038/s41591-023-02525-y},
journal = {Nat Med},
pages = {2498--2508},
title = {Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization.},
url = {http://dx.doi.org/10.1038/s41591-023-02525-y},
volume = {29},
year = {2023}
}

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TY  - JOUR
AB  - Post-COVID cognitive deficits, including 'brain fog', are clinically complex, with both objective and subjective components. They are common and debilitating, and can affect the ability to work, yet their biological underpinnings remain unknown. In this prospective cohort study of 1,837 adults hospitalized with COVID-19, we identified two distinct biomarker profiles measured during the acute admission, which predict cognitive outcomes 6 and 12 months after COVID-19. A first profile links elevated fibrinogen relative to C-reactive protein with both objective and subjective cognitive deficits. A second profile links elevated D-dimer relative to C-reactive protein with subjective cognitive deficits and occupational impact. This second profile was mediated by fatigue and shortness of breath. Neither profile was significantly mediated by depression or anxiety. Results were robust across secondary analyses. They were replicated, and their specificity to COVID-19 tested, in a large-scale electronic health records dataset. These findings provide insights into the heterogeneous biology of post-COVID cognitive deficits.
AU  - Taquet,M
AU  - Skorniewska,Z
AU  - Hampshire,A
AU  - Chalmers,JD
AU  - Ho,L-P
AU  - Horsley,A
AU  - Marks,M
AU  - Poinasamy,K
AU  - Raman,B
AU  - Leavy,OC
AU  - Richardson,M
AU  - Elneima,O
AU  - McAuley,HJC
AU  - Shikotra,A
AU  - Singapuri,A
AU  - Sereno,M
AU  - Saunders,RM
AU  - Harris,VC
AU  - Houchen-Wolloff,L
AU  - Greening,NJ
AU  - Mansoori,P
AU  - Harrison,EM
AU  - Docherty,AB
AU  - Lone,NI
AU  - Quint,J
AU  - Sattar,N
AU  - Brightling,CE
AU  - Wain,LV
AU  - Evans,RE
AU  - Geddes,JR
AU  - Harrison,PJ
AU  - PHOSP-COVID,Study Collaborative Group
DO  - 10.1038/s41591-023-02525-y
EP  - 2508
PY  - 2023///
SP  - 2498
TI  - Acute blood biomarker profiles predict cognitive deficits 6 and 12 months after COVID-19 hospitalization.
T2  - Nat Med
UR  - http://dx.doi.org/10.1038/s41591-023-02525-y
UR  - https://www.ncbi.nlm.nih.gov/pubmed/37653345
VL  - 29
ER  -

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