My fundamental interests are in bacterial transcription control and their synthetic design to investigate and direct cell systems behaviour. We use synthetic and systems biology approaches to better understand how molecular mechanisms impact on systems behaviour. Research activities focus on the molecular mechanisms that underpin bacterial system behaviour, with the view to predictably alter their physiology and behaviour through synthetic regulatory networks. For example, we study the molecular program of Pseudomonas syringae that triggers plant pathogenicity and the regulation of nitrogen assimilation and fixation in a various bacteria. I am coordinating the systems and synthetic biology aspects of our strategic LoLa award to engineer nitrogen fixing bacteria to reduce our dependency on chemically produced nitrogen fertilisers (RCUK: BB/N003608/1).
et al., 2014, Interplay among Pseudomonas syringae HrpR, HrpS and HrpV proteins for regulation of the type III secretion system, Fems Microbiology Letters, Vol:356, ISSN:0378-1097, Pages:201-211
et al., 2014, Differential secretome analysis of Pseudomonas syringae pv tomato using gel-free MS proteomics, Frontiers in Plant Science, Vol:5, ISSN:1664-462X
et al., 2013, Nitrogen and Carbon Status Are Integrated at the Transcriptional Level by the Nitrogen Regulator NtrC In Vivo, Mbio, Vol:4, ISSN:2150-7511
et al., 2013, Rewiring cell signalling through chimaeric regulatory protein engineering, Biochemical Society Transactions, Vol:41, ISSN:0300-5127, Pages:1195-1200
et al., 2012, The RecX protein interacts with the RecA protein and modulates its activity in Herbaspirillum seropedicae, Brazilian Journal of Medical and Biological Research, Vol:45, ISSN:0100-879X, Pages:1127-1134