Publications
245 results found
BALIGA R, LAMMERTSMA A, RHODES C, et al., 1995, POSITRON EMISSION TOMOGRAPHY LOCALIZES INSULIN-RESISTANCE TO SKELETAL-MUSCLE IN PREMATURE CORONARY HEART-DISEASE, CIRCULATION, Vol: 92, Pages: 77-77, ISSN: 0009-7322
- Author Web Link
- Cite
- Citations: 3
KOONER JS, BALIGA RR, WILDING J, et al., 1995, METABOLIC PHENOTYPES FOR GENETIC-ANALYSIS IN CORONARY HEART-DISEASE, CIRCULATION, Vol: 92, Pages: 76-76, ISSN: 0009-7322
- Author Web Link
- Cite
- Citations: 1
Brett DJ, Pease RJ, Scott J, et al., 1995, Microsomal triglyceride transfer protein activity remains unchanged in rat livers under conditions of altered very-low-density lipoprotein secretion., Biochem J, Vol: 310 ( Pt 1), Pages: 11-14, ISSN: 0264-6021
Microsomal triglyceride transfer protein (MTP) is a heterodimeric protein consisting of a unique 97 kDa subunit and protein disulphide isomerase, that mediates the transfer of lipid between membranes and nascent lipoproteins. Mutations in the gene encoding the 97 kDa subunit of the protein cause the rare autosomal recessive disorder abetalipoproteinaemia. Recent findings in cultured cells indicate that the 5' promoter region contains an insulin-responsive element, suggesting that the gene is responsive to insulin regulation. In this study we examined two cases where very-low-density lipoprotein (VLDL) secretion is markedly reduced: the streptozotocin-diabetic rat and 10-day-old suckling rats. In both cases MTP activity was unaltered compared with that in control animals. Equal levels of MTP were also apparent in the livers of all groups of animals, as measured by immunoblotting with an anti-MTP antiserum. These findings indicate that factors other than MTP activity are responsible for the reduction in hepatic VLDL triglyceride secretion observed in the suckling and diabetic animals.
SCOTT J, 1995, A PLACE IN THE WORLD FOR RNA EDITING, CELL, Vol: 81, Pages: 833-836, ISSN: 0092-8674
- Author Web Link
- Cite
- Citations: 99
NAVARATNAM N, BHATTACHARYA S, FUJINO T, et al., 1995, EVOLUTIONARY ORIGINS OF APO-B MESSENGER-RNA EDITING - CATALYSIS BY A CYTIDINE DEAMINASE THAT HAS ACQUIRED A NOVEL RNA-BINDING MOTIF AT ITS ACTIVE-SITE, CELL, Vol: 81, Pages: 187-195, ISSN: 0092-8674
- Author Web Link
- Cite
- Citations: 155
Scott J, Hobbs HH, 1995, Genetics and molecular biology., Curr Opin Lipidol, Vol: 6, Pages: 67-69, ISSN: 0957-9672
Pease RJ, Leiper JM, Harrison GB, et al., 1995, Studies on the translocation of the amino terminus of apolipoprotein B into the endoplasmic reticulum., J Biol Chem, Vol: 270, Pages: 7261-7271, ISSN: 0021-9258
Apolipoprotein (apo) B is either co-translationally assembled into lipoproteins, or becomes associated with the membrane of the endoplasmic reticulum (ER) and is subsequently degraded. It has been proposed that apoB undergoes a novel process of translocation which generates cytoplasmically exposed apoB in the ER of hepatic and non-hepatic cells. Transmembrane forms of apoB can also be generated by in vitro translation (Chuck, S. L., and Lingappa, V. R. (1992) Cell 68, 9-21), which might explain the origin of untranslocated apoB in vivo. Here we have investigated a protocol which generates transmembrane forms of apoB during in vitro translation of truncated RNA transcripts. We observe that apoB can become transmembrane at sites of ribosome pausing and be held in this configuration by persistence of tRNA on the peptide chains. Ribosome pausing also occurs at these same sites in the absence of acceptor microsomes. Transmembrane topology can be generated at sites of ribosome pausing in a cytosolic protein, sea urchin cyclin when fused to a signal sequence. Mapping of the ribosome pause sites in apoB and in cyclin revealed no amino acid sequence homology. Chimeric constructs with engineered downstream glycosylation sites showed no evidence that ribosome pause sequences affect translocation of transcripts with termination codons. Transmembrane forms of apoB and cyclin were not generated during translocation into the ER in transfected COS cells.
VERHOEVEN AJM, WOODS A, BRENNAN CH, et al., 1995, THE AMP-ACTIVATED PROTEIN-KINASE GENE IS HIGHLY EXPRESSED IN RAT SKELETAL-MUSCLE - ALTERNATIVE SPLICING AND TISSUE DISTRIBUTION OF THE MESSENGER-RNA, EUROPEAN JOURNAL OF BIOCHEMISTRY, Vol: 228, Pages: 236-243, ISSN: 0014-2956
- Author Web Link
- Cite
- Citations: 57
DAVIDSON NO, INNERARITY TL, SCOTT J, et al., 1995, PROPOSED NOMENCLATURE FOR THE CATALYTIC SUBUNIT OF THE MAMMALIAN APOLIPOPROTEIN-B MESSENGER-RNA EDITING ENZYME - APOBEC-1, RNA, Vol: 1, Pages: 3-3, ISSN: 1355-8382
- Author Web Link
- Cite
- Citations: 69
Scott J, Bhattacharya S, Navaratnam N, et al., 1995, The catalytic subunit of the editing enzyme is a zinc-containing cytidine deaminase with an RNA-binding motif at its active site, Atherosclerosis X, Editors: Davignon, Woodford, Sniderman, Publisher: Elsevier Science Ltd, Pages: 949-952, ISBN: 9780444820075
Greeve J, Scott J, 1995, In vitro mRNA editing using S100 extracts., Methods Mol Biol, Vol: 37, Pages: 77-87, ISSN: 1064-3745
BERI RK, MARLEY AE, SEE CG, et al., 1994, MOLECULAR-CLONING, EXPRESSION AND CHROMOSOMAL LOCALIZATION OF HUMAN AMP-ACTIVATED, FEBS LETTERS, Vol: 356, Pages: 117-121, ISSN: 0014-5793
- Author Web Link
- Cite
- Citations: 32
TENG BB, BLUMENTHAL S, FORTE T, et al., 1994, ADENOVIRUS-MEDIATED GENE-TRANSFER OF RAT APOLIPOPROTEIN-B MESSENGER-RNA-EDITING PROTEIN IN MICE VIRTUALLY ELIMINATES APOLIPOPROTEIN B-100 AND NORMAL LOW-DENSITY-LIPOPROTEIN PRODUCTION, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 29395-29404, ISSN: 0021-9258
- Author Web Link
- Cite
- Citations: 84
AGUAN K, SCOTT J, SEE CG, et al., 1994, CHARACTERIZATION AND CHROMOSOMAL LOCALIZATION OF THE HUMAN HOMOLOG OF A RAT AMP-ACTIVATED PROTEIN KINASE-ENCODING GENE - A MAJOR REGULATOR OF LIPID-METABOLISM IN MAMMALS, GENE, Vol: 149, Pages: 345-350, ISSN: 0378-1119
- Author Web Link
- Cite
- Citations: 25
HUGHES SD, ROUY D, NAVARA N, et al., 1994, INTRODUCTION OF APOLIPOPROTEIN-B MESSENGER-RNA EDITING FACTOR P27 INCREASES IN-VIVO HEPATIC APO-B EDITING IN RABBITS AND MICE, CIRCULATION, Vol: 90, Pages: 1-1, ISSN: 0009-7322
- Author Web Link
- Cite
- Citations: 1
LEIPER JM, BAYLISS JD, PEASE RJ, et al., 1994, MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, THE ABETALIPOPROTEINEMIA GENE-PRODUCT, MEDIATES THE SECRETION OF APOLIPOPROTEIN B-CONTAINING LIPOPROTEINS FROM HETEROLOGOUS CELLS, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 21951-21954, ISSN: 0021-9258
- Author Web Link
- Cite
- Citations: 152
Cullen P, Farren B, Scott J, et al., 1994, Complex segregation analysis provides evidence for a major gene acting on serum triglyceride levels in 55 British families with familial combined hyperlipidemia., Arterioscler Thromb, Vol: 14, Pages: 1233-1249, ISSN: 1049-8834
Familial combined hyperlipidemia (FCHL) was first described as an autosomal dominant inherited trait with primary action on triglyceride levels and secondary effects on cholesterol metabolism. This conclusion has since been questioned by several groups despite subsequent supportive biochemical and metabolic studies. To reexplore the genetics of FCHL, we assembled 55 families from the United Kingdom comprising 559 persons ascertained through probands with both hypercholesterolemia and hypertriglyceridemia. The results of univariate complex segregation analysis were consistent with a major gene acting on triglyceride and explaining two thirds of the genetic variability and 20% of the phenotypic variance in triglyceride levels. Univariate analysis did not identify a major genetic component acting on cholesterol levels. Bivariate segregation analysis rejected a major gene model. We also reexamined the original FCHL pedigrees collected by Goldstein et al and obtained results similar to those in the UK families. The prospects for mapping putative major genes determining triglyceride levels in FCHL patients by linkage analysis are discussed.
WOODS A, MUNDAY MR, SCOTT J, et al., 1994, YEAST SNF1 IS FUNCTIONALLY RELATED TO MAMMALIAN AMP-ACTIVATED PROTEIN-KINASE AND REGULATES ACETYL-COA CARBOXYLASE IN-VIVO, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 19509-19515, ISSN: 0021-9258
- Author Web Link
- Cite
- Citations: 332
Shoulders CC, Narcisi TM, Read J, et al., 1994, The abetalipoproteinemia gene is a member of the vitellogenin family and encodes an alpha-helical domain., Nat Struct Biol, Vol: 1, Pages: 285-286, ISSN: 1072-8368
CARLING D, AGUAN K, WOODS A, et al., 1994, MAMMALIAN AMP-ACTIVATED PROTEIN-KINASE IS HOMOLOGOUS TO YEAST AND PLANT PROTEIN-KINASES INVOLVED IN THE REGULATION OF CARBON METABOLISM, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 269, Pages: 11442-11448, ISSN: 0021-9258
- Author Web Link
- Cite
- Citations: 201
Scott J, Navaratnam N, Bhattacharya S, et al., 1994, The apolipoprotein B messenger RNA editing enzyme., Curr Opin Lipidol, Vol: 5, Pages: 87-93, ISSN: 0957-9672
The editing of apolipoprotein (apo)B messenger RNA (mRNA) involves a novel C to U modification, which creates an in-frame stop-translation codon, thereby generating the carboxyl-terminal of apoB48. The 27 kDa catalytic subunit of the editing enzyme has been cloned and established to be a zinc-containing cytidine deaminase. The catalytic subunit is guided to the editing site by a second targeting subunit or subunits. A candidate for the targeting subunit is a 60 kDa protein that can be UV crosslinked to the sequence UGAU, which is part of a motif downstream of the editing site that is essential for editing.
BHATTACHARYA S, NAVARATNAM N, MORRISON JR, et al., 1994, CYTOSINE NUCLEOSIDE/NUCLEOTIDE DEAMINASES AND APOLIPOPROTEIN-B MESSENGER-RNA EDITING, TRENDS IN BIOCHEMICAL SCIENCES, Vol: 19, Pages: 105-106, ISSN: 0968-0004
- Author Web Link
- Cite
- Citations: 41
Perraudeau M, Scott J, Walport M, et al., 1994, Late presentation of Kartagener's syndrome. Consequences of ciliary dysfunction., BMJ, Vol: 308, Pages: 519-521, ISSN: 0959-8138
SHOVLIN CL, HUGHES JMB, TUDDENHAM EGD, et al., 1994, A GENE FOR HEREDITARY HEMORRHAGIC TELANGIECTASIA MAPS TO CHROMOSOME 9Q3, NATURE GENETICS, Vol: 6, Pages: 205-209, ISSN: 1061-4036
- Author Web Link
- Cite
- Citations: 155
Scott J, 1994, Apolipoprotein B and coronary heart disease, From genetics to gene therapy, Editors: Latchman, Publisher: Garland Science, Pages: 7-23, ISBN: 9781872748368
SHOULDERS CC, BRETT DJ, BAYLISS JD, et al., 1993, ABETALIPOPROTEINEMIA IS CAUSED BY DEFECTS OF THE GENE ENCODING THE 97 KDA SUBUNIT OF A MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN, HUMAN MOLECULAR GENETICS, Vol: 2, Pages: 2109-2116, ISSN: 0964-6906
- Author Web Link
- Cite
- Citations: 216
Lord GM, Scott J, Pusey CD, et al., 1993, Diabetes and rhabdomyolysis. A rare complication of a common disease., BMJ, Vol: 307, Pages: 1126-1128, ISSN: 0959-8138
Clifford CP, Davies GJ, Scott J, et al., 1993, Tuberculous pericarditis with rapid progression to constriction. Prompt diagnosis and treatment are needed., BMJ, Vol: 307, Pages: 1052-1054, ISSN: 0959-8138
NAVARATNAM N, MORRISON JR, BHATTACHARYA S, et al., 1993, THE P27 CATALYTIC SUBUNIT OF THE APOLIPOPROTEIN-B MESSENGER-RNA EDITING ENZYME IS A CYTIDINE DEAMINASE, JOURNAL OF BIOLOGICAL CHEMISTRY, Vol: 268, Pages: 20709-20712, ISSN: 0021-9258
- Author Web Link
- Cite
- Citations: 243
Narcisi TM, Schotz MC, Scott J, et al., 1993, Dinucleotide repeat polymorphisms at the lipoprotein lipase (LPL) locus., Hum Genet, Vol: 92, Pages: 312-313, ISSN: 0340-6717
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.