Imperial College London
Alternate

ProfessorJamesScott

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Cardiovascular Medicine
 
 
 
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Contact

 

j.scott

 
 
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Location

 

Rm. 529ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rorsman:1988:10.1128/mcb.8.2.571-577.1988,
author = {Rorsman, F and Bywater, M and Knott, TJ and Scott, J and Betsholtz, C},
doi = {10.1128/mcb.8.2.571-577.1988},
journal = {Mol Cell Biol},
pages = {571--577},
title = {Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins.},
url = {http://dx.doi.org/10.1128/mcb.8.2.571-577.1988},
volume = {8},
year = {1988}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The human platelet-derived growth factor (PDGF) A-chain locus was characterized by restriction endonuclease analysis, and the nucleotide sequence of its exons was determined. Seven exons were identified, spanning approximately 22 kilobase pairs of genomic DNA. Alternative exon usage, identified by cDNA cloning, occurs in a human glioblastoma cell line and may give rise to two types of A-chain precursors with different C termini. The exon-intron arrangement was similar to that of the PDGF B-chain/sis locus and seemed to divide the precursor proteins into functional domains. Southern blot analysis of genomic DNA showed that a single PDGF A-chain gene was present in the human genome.
AU  - Rorsman,F
AU  - Bywater,M
AU  - Knott,TJ
AU  - Scott,J
AU  - Betsholtz,C
DO  - 10.1128/mcb.8.2.571-577.1988
EP  - 577
PY  - 1988///
SN  - 0270-7306
SP  - 571
TI  - Structural characterization of the human platelet-derived growth factor A-chain cDNA and gene: alternative exon usage predicts two different precursor proteins.
T2  - Mol Cell Biol
UR  - http://dx.doi.org/10.1128/mcb.8.2.571-577.1988
UR  - https://www.ncbi.nlm.nih.gov/pubmed/2832727
VL  - 8
ER  -
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