Imperial College London
Alternate

ProfessorJamesScott

Faculty of Medicine, National Heart & Lung Institute

Emeritus Professor of Cardiovascular Medicine
 
 
 
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Contact

 

j.scott

 
 
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Location

 

Rm. 529ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Seth:2007:10.1016/j.cmet.2007.08.004,
author = {Seth, A and Steel, JH and Nichol, D and Pocock, V and Kumaran, MK and Fritah, A and Mobberley, M and Ryder, TA and Rowlerson, A and Scott, J and Poutanen, M and White, R and Parker, M},
doi = {10.1016/j.cmet.2007.08.004},
journal = {Cell Metabolism},
pages = {236--245},
title = {The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle},
url = {http://dx.doi.org/10.1016/j.cmet.2007.08.004},
volume = {6},
year = {2007}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Nuclear receptor signaling plays an important  role in energy metabolism. In this study we  demonstrate that the nuclear receptor corepressor  RIP140 is a key regulator of metabolism  in skeletal muscle. RIP140 is expressed in a fiber  type-specific manner, and manipulation of its  levels in null, heterozygous, and transgenic  mice demonstrate that low levels promote while  increased expression suppresses the formation  of oxidative fibers. Expression profiling reveals  global changes in the expression of genes  implicated in both myofiber phenotype and  metabolic functions. Genes involved in fattyacid  oxidation, oxidative phosphorylation, and  mitochondrial biogenesis are upregulated in  the absence of RIP140. Analysis of cultured  myofibers demonstrates that the changes in  expression are intrinsic to muscle cells and  that nuclear receptor-regulated genes are  direct targets for repression by RIP140. Therefore  RIP140 is an important signaling factor in  the regulation of skeletal muscle function and  physiology.
AU  - Seth,A
AU  - Steel,JH
AU  - Nichol,D
AU  - Pocock,V
AU  - Kumaran,MK
AU  - Fritah,A
AU  - Mobberley,M
AU  - Ryder,TA
AU  - Rowlerson,A
AU  - Scott,J
AU  - Poutanen,M
AU  - White,R
AU  - Parker,M
DO  - 10.1016/j.cmet.2007.08.004
EP  - 245
PY  - 2007///
SN  - 1932-7420
SP  - 236
TI  - The transcriptional corepressor RIP140 regulates oxidative metabolism in skeletal muscle
T2  - Cell Metabolism
UR  - http://dx.doi.org/10.1016/j.cmet.2007.08.004
UR  - http://hdl.handle.net/10044/1/32864
VL  - 6
ER  -
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