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@article{Tascini:2019:10.1039/c8cp05706k,
author = {Tascini, AS and Noro, MG and Seddon, JM and Chen, R and Bresme, F},
doi = {10.1039/c8cp05706k},
journal = {Physical Chemistry Chemical Physics},
pages = {1471--1477},
title = {Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides},
url = {http://dx.doi.org/10.1039/c8cp05706k},
volume = {21},
year = {2019}
}

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TY  - JOUR
AB  - The skin surface, our first barrier against the external environment, is covered by the sebum oil, a lipid film composed of sebaceous and epidermal lipids, which is important in the regulation of the hydration level of our skin. Here, we investigate the pathways leading to the transfer of epidermal lipids from the skin lipid bilayer to the sebum. We show that the sebum triglycerides, a major component of sebum, interact strongly with the epidermal lipids and extract them from the bilayer. Using microsecond time scale molecular dynamics simulations, we identify and quantify the free energy associated with the skin lipid extraction process.
AU  - Tascini,AS
AU  - Noro,MG
AU  - Seddon,JM
AU  - Chen,R
AU  - Bresme,F
DO  - 10.1039/c8cp05706k
EP  - 1477
PY  - 2019///
SN  - 1463-9076
SP  - 1471
TI  - Mechanisms of lipid extraction from skin lipid bilayers by sebum triglycerides
T2  - Physical Chemistry Chemical Physics
UR  - http://dx.doi.org/10.1039/c8cp05706k
UR  - https://www.ncbi.nlm.nih.gov/pubmed/30607404
UR  - http://hdl.handle.net/10044/1/66704
VL  - 21
ER  -

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