Imperial College London

DrJenniferTweedy

Faculty of EngineeringDepartment of Bioengineering

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3663j.siggers Website

 
 
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Location

 

4.30Royal School of MinesSouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
to

55 results found

Roney CH, Cantwell CD, Bayer JD, Qureshi NA, Lim PB, Tweedy JH, Kanagaratnam P, Peters NS, Vigmond EJ, Ng FSet al., 2017, Spatial Resolution Requirements for Accurate Identification of Drivers of Atrial Fibrillation, CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY, Vol: 10, ISSN: 1941-3149

JOURNAL ARTICLE

Roney CH, Cantwell CD, Qureshi NA, Chowdhury RA, Dupont E, Lim PB, Vigmond EJ, Tweedy JH, Ng FS, Peters NSet al., 2017, Rotor Tracking Using Phase of Electrograms Recorded During Atrial Fibrillation, ANNALS OF BIOMEDICAL ENGINEERING, Vol: 45, Pages: 910-923, ISSN: 0090-6964

JOURNAL ARTICLE

Baksi AJ, Davies JE, Hadjiloizou N, Baruah R, Unsworth B, Foale RA, Korolkova O, Siggers JH, Francis DP, Mayet J, Parker KH, Hughes ADet al., 2016, Attenuation of reflected waves in man during retrograde propagation from femoral artery to proximal aorta, INTERNATIONAL JOURNAL OF CARDIOLOGY, Vol: 202, Pages: 441-445, ISSN: 0167-5273

JOURNAL ARTICLE

Schobesberger S, Jonsson P, Buzuk A, Korchev Y, Siggers J, Gorelik Jet al., 2016, Nanoscale, Voltage-Driven Application of Bioactive Substances onto Cells with Organized Topography, BIOPHYSICAL JOURNAL, Vol: 110, Pages: 141-146, ISSN: 0006-3495

JOURNAL ARTICLE

Ali RL, Cantwell CD, Qureshi NA, Roney CH, Lim PB, Sherwin SJ, Siggers JH, Peters NSet al., 2015, Automated fiducial point selection for reducing registration error in the co-localisation of left atrium electroanatomic and imaging data, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Publisher: IEEE, Pages: 1989-1992, ISSN: 1557-170X

CONFERENCE PAPER

Cantwell CD, Roney CH, Ng FS, Siggers JH, Sherwin SJ, Peters NSet al., 2015, Techniques for automated local activation time annotation and conduction velocity estimation in cardiac mapping, COMPUTERS IN BIOLOGY AND MEDICINE, Vol: 65, Pages: 229-242, ISSN: 0010-4825

JOURNAL ARTICLE

Dehbi H-M, Jones S, Sohaib SMA, Finegold JA, Siggers JH, Stegemann B, Whinnett ZI, Francis DPet al., 2015, A novel curve fitting method for AV optimisation of biventricular pacemakers, PHYSIOLOGICAL MEASUREMENT, Vol: 36, Pages: 1889-1900, ISSN: 0967-3334

JOURNAL ARTICLE

Repetto R, Khongar PD, Pralits JO, Siggers JH, Soleri Pet al., 2015, Numerical simulations of flow and mass transport processes in the anterior chamber in the presence of an iris-fixated intraocular lens, Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), Publisher: ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ISSN: 0146-0404

CONFERENCE PAPER

Repetto R, Pralits JO, Siggers JH, Soleri Pet al., 2015, Phakic iris-fixated intraocular lens placement in the anterior chamber: effects on aqueous flow., Investigative Ophthalmology & Visual Science, Vol: 56, Pages: 3061-3068, ISSN: 1552-5783

PURPOSE: Phakic intraocular lenses (pIOLs) are used for correcting vision; in this paper we investigate the fluid dynamical effects of an iris-fixated lens in the anterior chamber. In particular, we focus on changes in the wall shear stress (WSS) on the cornea and iris, which could be responsible for endothelial and pigment cell loss, respectively, and also on the possible increase of the intraocular pressure, which is known to correlate with the incidence of secondary glaucoma. METHODS: We use a mathematical model to study fluid flow in the anterior chamber in the presence of a pIOL. The governing equations are solved numerically using the open source software OpenFOAM. We use an idealized standard geometry for the anterior chamber and a realistic geometric description of the pIOL. RESULTS: We consider separately the main mechanisms that produce fluid flow in the anterior chamber. The numerical simulations allow us to obtain a detailed description of the velocity and pressure distribution in the anterior chamber, and indicated that implantation of the pIOL significantly modifies the fluid dynamics in the anterior chamber. However, lens implantation has negligible influence on the intraocular pressure and does not produce a significant increase of the shear stress on the cornea, while the shear stress on the iris, although increased, is not enough to cause detachment of cells. CONCLUSIONS: We conclude that alterations in the fluid dynamics in the anterior chamber as a result of lens implantation are unlikely to be the cause of medical complications associated with its use.

JOURNAL ARTICLE

Roney CH, Tzortzis KN, Cantwell CD, Qureshi NA, Ali RL, Lim PB, Siggers JH, Ng FS, Peters NSet al., 2015, A Technique for Visualising Three-Dimensional Left Atrial Cardiac Activation Data in Two Dimensions with Minimal Distance Distortion, 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Publisher: IEEE, Pages: 7296-7299, ISSN: 1557-170X

CONFERENCE PAPER

Ali RL, Cantwell CD, Roney CH, Qureshi NA, Lim PB, Siggers JH, Sherwin SJ, Peters NSet al., 2014, A novel method for quantifying localised correlation of late-gadolinium intensity with conduction velocity, 41st Computing in Cardiology Conference (CinC), Publisher: IEEE, Pages: 193-196, ISSN: 0276-6574

CONFERENCE PAPER

Debbaut C, Vierendeels J, Siggers JH, Repetto R, Monbaliu D, Segers Pet al., 2014, A 3D porous media liver lobule model: the importance of vascular septa and anisotropic permeability for homogeneous perfusion, COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING, Vol: 17, Pages: 1295-1310, ISSN: 1025-5842

JOURNAL ARTICLE

Park CM, Korolkova O, Davies JE, Parker KH, Siggers JH, March K, Tillin T, Chaturvedi N, Hughes ADet al., 2014, Arterial pressure: agreement between a brachial cuff-based device and radial tonometry, JOURNAL OF HYPERTENSION, Vol: 32, Pages: 865-872, ISSN: 0263-6352

JOURNAL ARTICLE

Repetto R, Siggers JH, Meskauskas J, 2014, Steady streaming of a viscoelastic fluid within a periodically rotating sphere, JOURNAL OF FLUID MECHANICS, Vol: 761, ISSN: 0022-1120

JOURNAL ARTICLE

Roney CH, Cantwell CD, Qureshi NA, Ali RL, Chang ETY, Lim PB, Sherwin SJ, Peters NS, Siggers JH, Ng FSet al., 2014, An Automated Algorithm for Determining Conduction Velocity, Wavefront Direction and Origin of Focal Cardiac Arrhythmias Using a Multipolar Catheter, 36th Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (EMBC), Publisher: IEEE, Pages: 1583-1586, ISSN: 1557-170X

CONFERENCE PAPER

Roney CH, Cantwell CD, Siggers JH, Ng FS, Peters NSet al., 2014, A Novel Method for Rotor Tracking Using Bipolar Electrogram Phase, 41st Computing in Cardiology Conference (CinC), Publisher: IEEE, Pages: 233-236, ISSN: 0276-6574

CONFERENCE PAPER

Siggers JH, Leungchavaphongse K, Ho CH, Repetto Ret al., 2014, Mathematical model of blood and interstitial flow and lymph production in the liver, BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Vol: 13, Pages: 363-378, ISSN: 1617-7959

JOURNAL ARTICLE

Bonfiglio A, Repetto R, Siggers JH, Stocchino Aet al., 2013, Investigation of the motion of a viscous fluid in the vitreous cavity induced by eye rotations and implications for drug delivery, PHYSICS IN MEDICINE AND BIOLOGY, Vol: 58, Pages: 1969-1982, ISSN: 0031-9155

JOURNAL ARTICLE

Putra NK, Dickinson RJ, Siggers JH, 2013, Image Processing as the Validation Method of Droplet Dispersion Modeling Process, 3rd International Conference on Instrumentation, Communications, Information Technology, and Biomedical Engineering (ICICI-BME), Publisher: IEEE, Pages: 242-245, ISSN: 2158-0456

CONFERENCE PAPER

Setchi A, Mestel AJ, Parker KH, Siggers JHet al., 2013, Low-Reynolds-number flow through two-dimensional shunts, JOURNAL OF FLUID MECHANICS, Vol: 723, Pages: 21-39, ISSN: 0022-1120

JOURNAL ARTICLE

Setchi A, Mestel AJ, Siggers JH, Parker KH, Tan MW, Wong Ket al., 2013, Mathematical model of flow through the patent ductus arteriosus, JOURNAL OF MATHEMATICAL BIOLOGY, Vol: 67, Pages: 1487-1506, ISSN: 0303-6812

JOURNAL ARTICLE

Alastruey J, Siggers JH, Peiffer V, Doorly DJ, Sherwin SJet al., 2012, Reducing the data: Analysis of the role of vascular geometry on blood flow patterns in curved vessels, PHYSICS OF FLUIDS, Vol: 24, ISSN: 1070-6631

JOURNAL ARTICLE

Bell CG, Anastassiou CA, O'Hare D, Parker KH, Siggers JHet al., 2012, Theoretical treatment of high-frequency, large-amplitude ac voltammetry applied to ideal surface-confined redox systems, ELECTROCHIMICA ACTA, Vol: 64, Pages: 71-80, ISSN: 0013-4686

JOURNAL ARTICLE

Bell CG, Howell PD, Stone HA, Lim W-J, Siggers JHet al., 2012, The long-time chronoamperometric current at an inlaid disk electrode, JOURNAL OF ELECTROANALYTICAL CHEMISTRY, Vol: 673, Pages: 48-57, ISSN: 1572-6657

JOURNAL ARTICLE

Bonfiglio A, Stocchino A, Repetto R, Siggers JHet al., 2012, IN-VITRO SIMULATIONS OF DRUG DELIVERY IN THE VITREOUS CHAMBER OF THE EYE, ASME Summer Bioengineering Conference (SBC), Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 1171-1172

CONFERENCE PAPER

Meskauskas J, Repetto R, Siggers JH, 2012, Shape Change of the Vitreous Chamber Influences Retinal Detachment and Reattachment Processes: Is Mechanical Stress during Eye Rotations a Factor?, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Vol: 53, Pages: 6271-6281, ISSN: 0146-0404

JOURNAL ARTICLE

Meskauskas J, Repetto R, Siggers JH, 2012, THEORETICAL MODEL OF THE DYNAMIC STRESS ON THE RETINA DURING EYE ROTATIONS, ASME Summer Bioengineering Conference (SBC), Publisher: AMER SOC MECHANICAL ENGINEERS, Pages: 1177-1178

CONFERENCE PAPER

Roney CH, Ng FS, Chowdhury RA, Chang ETY, Patel PM, Lyon AR, Siggers JH, Peters NSet al., 2012, Hysteresis of cardiac action potential duration restitution occurs in the absence of calcium transient duration hysteresis - a dual optical mapping study of ex vivo rat hearts, 2nd Congress of the European-Society-of-Cardiology Council on Basic Cardiovascular Science - Frontiers in Cardiovascular Biology, Publisher: OXFORD UNIV PRESS, Pages: S63-S63, ISSN: 0008-6363

CONFERENCE PAPER

Siggers JH, Ethier CR, 2012, Fluid Mechanics of the Eye, Editors: Davis, Moin, Publisher: ANNUAL REVIEWS, Pages: 347-372

BOOK CHAPTER

Artzrouni M, Begg CB, Chabiniok R, Clairambault J, Foss AJE, Hargrove J, Lee EK, Siggers JH, Tindall Met al., 2011, The first international workshop on the role and impact of mathematics in medicine: A collective account, AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, Vol: 3, Pages: 492-497, ISSN: 1943-8141

JOURNAL ARTICLE

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