Imperial College London


Faculty of EngineeringDepartment of Bioengineering

Senior Lecturer



+44 (0)20 7594 3663j.siggers Website




4.30Royal School of MinesSouth Kensington Campus





This webpage summarises my research activities. My main research involves the application of fluid mechanics and continuum mechanics to understanding biomedical problems. My general approach is to simplify and idealise the problem to make it possible to solve analytically or semi-analytically. This approach increases our fundamental understanding of the problem, and leads to new insight into key areas of physiology and medicine.

Areas of application

show research

Areas of current research interest include mathematical modelling of the following phenomena:

  • Fluid flow and mass transport in the eye
  • Blood flow and mass transport in the microcirculation of the liver
  • Blood flow in the arteries, including arterial curvature, compliance, wave intensity analysis, pathological conditions
  • Devices to measure arterial blood pressure
  • Propagation of electrical signals in the myocardium
  • Behaviour of electrochemical sensors

Image illustrating some of Dr Tweedy's research projects.


show research

I am an active member of the following societies:

I also run a Special Interest Group, which is part of the UK fluids network on Fluid Mechanics of the Eye with Eamonn Gaffney

Current members of my research group

show research

  • Maryam Argungu (PhD candidate, 2014-)
  • Paul Mannix (PhD student on Fluid Dynamics Across Scales CDT, 2016-, principal supervisor Dr Jonathan Mestel)
  • Raquel Henriquez Vaz (PhD student on Fluid Dynamics Across Scales CDT, 2015-, principal supervisor Dr Jonathan Mestel)
  • Karla Sanchez (PhD student with Kim Parker, 2014-)

We also have MSc students and undergraduate students in the group who are working on individual or group projects.

Former members of my research group

show research

  • Carmen Garcia (visiting researcher from University of Malaga, Spain, 2017)
  • Rheeda Ali (PhD candidate, 2012-2016)
  • Carlos Escobar del Pozo (visiting researcher from University of Colima, Mexico, 2015-2016)
  • Sang Lee (PhD candidate, principal supervisor Dr Reiko Tanaka, 2011-2015)
  • Raquel Henriquez Vaz (MRes student on Fluid Dynamics Across Scales CDT, 2014-2015, principal supervisor Dr Jonathan Mestel)
  • Alexandre Cornet (MSc student from ENS Paris, 2014-2015)
  • Sophie Schobesberger (PhD candidate, principal supervisor Dr Julia Gorelik, 2011-2015)
  • Caroline Roney (PhD candidate, 2011-2015)
  • Emmanuelle Flatt (MSc student from EPFL Lausanne, 2014-2015)
  • Hakim-Moulay Dehbi (MRes student, 2012-2013)
  • Dr Eugene Chang (PhD student, 2009-2013)
  • Dr Olga Korolkova (PhD student, 2009-2013)
  • Dr Kritsada Leungchavaphongse (PhD student, 2008-2013)
  • Nico Wazula (MSc student from TU Munich, 2012)
  • Dr Julia Meskauskas (PhD student, 2008-2012)
  • Dr Adriana Setchi (PhD student, 2007-2011)
  • Caroline Roney (MRes student, 2010-2011)
  • Dr Christopher Bell (postdoctoral researcher, 2008-2011)
  • Dr Sevil Payvandi (PhD student, 2006-2010)
  • Andrea Bonfiglio (MSc student from University of Genoa, 2007-2008)

They are all missed.


Professor Patrick Segers, University of Ghent, Belgium, 2010

Dr Darrel Francis, NHLI

Professor Spencer Sherwin, Department of Aeronautics

Dr Alexander Lyon, NHLI

Professor Kim Parker, Department of Bioengineering

Dr Jonathan Mestel, Department of Mathematics

Professor Nicholas Peters, NHLI

Dr Rodolfo Repetto, Department of Structures, Water and Soil Engineering

Dr Alessandro Stocchino, University of Genoa

Research Student Supervision

Dehbi,H-M, Optimisation of parameters for cardiac resynchronisation therapy (MRes student, co-supervisor Professor Darrel Francis, 2013-2013)

Ali,R, Mathematical modelling of cardiac arrhythmias: clinical data and mathematical modelling (PhD student, co-supervisors Professors Spencer Sherwin and Nicholas Peters)

Wazula,N, Flow in the anterior chamber of the eye (Masters student 2012-2012)

Roney,C, Developing a mathematical model to predict the onset of alternans and ventricular arrhythmias (PhD student, co-supervisors Prof Peters, Dr Ng)

Lee,S, Compound logics in cell signalling and gene expression (PhD student, principal supervisor Dr Tanaka)

Schobesberger,S, Mathematical modelling of feedback circuit in local cAMP/cGMP domains (PhD student, principal supervisor Dr Gorelik, co-supervisor Prof Harding)

Roney,C, Mathematical modelling of the cardiac electric signal (MRes student, 2010-11)

Payvandi,S, Blood flow in curved, compliant arteries (PhD student, 2006-10)

Chang,E, Modelling the propagation of electrical signals in the myocardium (PhD student, 2009-2013)

Setchi,A, Modelling cardiovascular flow and pressure in patients with patent ductus arteriosus (PhD student, 2007-2011)

Bonfiglio,A, Modelling the microcirculation of the liver (Masters student, 2007-8, principal supervisor Dr Repetto)

Meskauskas,J, Viscoelastic flow in the vitreous humour of the eye (PhD student, principal supervisor Dr Repetto, 2008-2012)

Leungchavaphongse,K, Microcirculation in the liver (PhD student, 2008-2013)

Korolkova,O, Devices to measure arterial blood pressure (PhD student, 2009-2013)