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@article{Peng:2021:10.1097/CCO.0000000000000800,
author = {Peng, L and Wang, Z and Stebbing, J and Yu, Z},
doi = {10.1097/CCO.0000000000000800},
journal = {Current Opinion in Oncology},
title = {Novel immunotherapeutic drugs for the treatment of lung cancer.},
url = {http://dx.doi.org/10.1097/CCO.0000000000000800},
year = {2021}
}

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TY  - JOUR
AB  - PURPOSE OF REVIEW: Cancer cells evade immune surveillance partly due to the immunosuppressive features of the tumor microenvironment (TME). Currently approved immuno-oncology drugs for the treatment of lung cancer are aimed to inhibit immune checkpoints, such as programmed death protein-1 (PD-1), PD ligand-1 (PD-L1) and cytotoxic T lymphocyte-associated antigen 4. Despite these, researchers are currently racing to create the optimal cancer immunotherapy treatments. RECENT FINDINGS: Novel immunotherapeutic drugs mainly act on activated immune cells and exert their therapeutic effects by enhancing antitumor responses. In this article, we review new therapies for the treatment of lung cancer that enhance T cell priming, remove coinhibitory signals, supply costimulatory signals and condition the TME. SUMMARY: As more immunotherapeutic targets are in studies, designing multimodal strategies to provide greater efficacy with lower toxicity will be necessary.
AU  - Peng,L
AU  - Wang,Z
AU  - Stebbing,J
AU  - Yu,Z
DO  - 10.1097/CCO.0000000000000800
PY  - 2021///
SN  - 1040-8746
TI  - Novel immunotherapeutic drugs for the treatment of lung cancer.
T2  - Current Opinion in Oncology
UR  - http://dx.doi.org/10.1097/CCO.0000000000000800
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34636350
UR  - https://journals.lww.com/co-oncology/Abstract/9000/Novel_immunotherapeutic_drugs_for_the_treatment_of.98971.aspx
ER  -

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