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@article{Peng:2022:10.21037/apm-21-2256,
author = {Peng, L and Yang, H and Zhao, Y and He, J and Stebbing, J and Chen, B},
doi = {10.21037/apm-21-2256},
journal = {Annals of Palliative Medicine},
pages = {2529--2537},
title = {Neurolymphomatosis of multifocal peripheral nerve involvement: a case report},
url = {http://dx.doi.org/10.21037/apm-21-2256},
volume = {11},
year = {2022}
}

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TY  - JOUR
AB  - The infiltration and invasion of nerve trunks, nerve roots, and cranial nerves by lymphomatousmalignant cells is defined as “neurolymphomatosis”. It is mainly caused by lymphoma cells directlyinfiltrating the peripheral nerves, with a low incidence. Neurolymphomatosis is a rare condition of neoplasticendoneurial invasion, which is primary or secondary to non-Hodgkin’s lymphoma and leukemia. We describea case of primary peripheral neurolymphomatosis of multifocal involvement in a 77-year-old male patient.He presented with left lower limb pain and was diagnosed with CD20+ diffuse large B cell lymphoma(DLBCL). Magnetic resonance imaging (MRI), fluorine-18 fluorodeoxyglucose (18F-FDG) positron emissiontomography (PET) computed tomography (CT), and nerve biopsy contributed to the diagnosis. Genomicprofiling, programmed death ligand-1 (PD-L1) expression and tumor mutational burden (TMB) were alsoassessed. CDKN2A/CDKN2B deletions have been identified. PD-L1 expression assessed by 28-8 antibodywas 1% positivity, and TMB of the sample was 11.6 muts/Mb. The patient responded well to rituximabcombined with chemotherapy, however, he died after 3 cycles of chemotherapy due to severe lung infectionand subsequent complication of respiratory failure. Here we report the clinical, radiological, pathological andmolecular findings of the patient affected by multifocal neurolymphomatosis without systemic involvementof other organs.
AU  - Peng,L
AU  - Yang,H
AU  - Zhao,Y
AU  - He,J
AU  - Stebbing,J
AU  - Chen,B
DO  - 10.21037/apm-21-2256
EP  - 2537
PY  - 2022///
SN  - 2224-5820
SP  - 2529
TI  - Neurolymphomatosis of multifocal peripheral nerve involvement: a case report
T2  - Annals of Palliative Medicine
UR  - http://dx.doi.org/10.21037/apm-21-2256
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000715509700001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://apm.amegroups.com/article/view/81332/html
UR  - http://hdl.handle.net/10044/1/93284
VL  - 11
ER  -

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