Imperial College London
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ProfessorJustinStebbing

Faculty of Medicine, Department of Surgery & Cancer

Visiting Professor
 
 
 
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Contact

 

j.stebbing Website CV

 
 
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Location

 

ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ríos:2022:10.1111/jgs.17620,
author = {Ríos, SS and Zamora, EBC and Céspedes, AA and Rizos, LR and Sánchez-Jurado, PM and Sánchez-Nievas, G and Romero, MM and Tabernero, Sahuquillo MT and Señalada, JJB and Romero, AM and Nogueras, IG and de, Dios Estrella Cazalla J and Andrés-Pretel, F and Lauschke, VM and Stebbing, J and Abizanda, P},
doi = {10.1111/jgs.17620},
journal = {Journal of the American Geriatrics Society},
pages = {650--658},
title = {Immunogenicity after six months of BNT162b2 vaccination in frail or disabled nursing home residents: the COVID-A Study},
url = {http://dx.doi.org/10.1111/jgs.17620},
volume = {70},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: There is incomplete information regarding evolution of antibody titers against SARS-CoV-2 after a two-dose strategy vaccination with BNT162b2, in older adults in long-term care facilities (LTCFs) with frailty, disability or cognitive impairment. We aimed to determine IgG antibody titer loss in old adults in LTCFs. METHODS: Multicenter longitudinal cohort study including 127 residents (90 females, 37 males) with a mean age of 82.7 years (range 65-99) with different frailty and disability profiles in two LTCFs in Albacete, Spain. Residents received 2 doses of BNT162b2 as per label, and antibody levels were determined 1 and 6 months after the second dose. Age, sex, previous history of COVID-19, comorbidity (Charlson index), performance in activities of daily living (Barthel index), frailty (FRAIL instrument), and cognitive status were assessed. RESULTS: The mean antibody titers 1 and 6 months after the second vaccine dose were 32,145 AU/mL (SD 41,206) and 6,182 AU/mL (SD 13,316) respectively. Across all participants, the median antibody titer loss measured 77.6% (IQR 23.8%). Notably, the decline of titers in individuals with pre-vaccination COVID-19 infection was significantly lower than in those without history of SARS-CoV-2 infection (72.2% vs 85.3%; p<.001). The median titer decrease per follow-up day was 0.47% (IQR 0.14%) and only pre-vaccination COVID-19 was associated with lower rate of antibody decline at 6 months (HR 0.17; 95% CI 0.07-0.41; p<.001). Frailty, disability, older age, cognitive impairment, or comorbidity were not associated with the extent of antibody loss. CONCLUSIONS: Older adults in LTCFs experience a rapid loss of antibodies between over the first six months after the second dose of BNT162b2 vaccine. Only pre-vaccination COVID-19 is associated with a slower rate of antibodies decrease. Our data support immunization with a third dose in this vulnerable, high-risk population. This article is protected by copyright. All ri
AU  - Ríos,SS
AU  - Zamora,EBC
AU  - Céspedes,AA
AU  - Rizos,LR
AU  - Sánchez-Jurado,PM
AU  - Sánchez-Nievas,G
AU  - Romero,MM
AU  - Tabernero,Sahuquillo MT
AU  - Señalada,JJB
AU  - Romero,AM
AU  - Nogueras,IG
AU  - de,Dios Estrella Cazalla J
AU  - Andrés-Pretel,F
AU  - Lauschke,VM
AU  - Stebbing,J
AU  - Abizanda,P
DO  - 10.1111/jgs.17620
EP  - 658
PY  - 2022///
SN  - 0002-8614
SP  - 650
TI  - Immunogenicity after six months of BNT162b2 vaccination in frail or disabled nursing home residents: the COVID-A Study
T2  - Journal of the American Geriatrics Society
UR  - http://dx.doi.org/10.1111/jgs.17620
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34894403
UR  - https://agsjournals.onlinelibrary.wiley.com/doi/10.1111/jgs.17620
UR  - http://hdl.handle.net/10044/1/93196
VL  - 70
ER  -
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