Dr Swann is a Reader (Associate Professor) in Microbiomics and Human Development within the Division of Integrative Systems Medicine and Digestive Diseases in the Department of Surgery and Cancer. Dr Swann is responsible for leading a metabonomic-based research programme to understand the influence of gene-environment interactions on the mammalian metabolic system and their implications for health and disease. His primary interests fall under two intersecting research themes:
(1) Role of the gut microbiota (the collection of microbes residing in the gastrointestinal tract) in the mammalian metabolic system and their association with host health and disease. This includes their contribution to host endogenous and xenobiotic metabolism, the gut-brain axis and its role in neurological disorders, the carcinogenic potential of the microbiome, and environmental and host factors shaping the acquisition and composition of the gut microbiome.
(2) Impact of early-life events and exposures on mammalian development particularly microbial-host interplay, metabolism, and phenotypic outcomes. A key research area is the application of metabolic phenotyping to the field of global health. Specifically, using a metabonomic approach to characterise the biochemical consequences of undernutrition and infection in children from developing countries to better understand the contributors to the long-term sequelae of early life undernutrition, including impaired cognitive, growth and metabolic functions.
Dr Swann’s research is supported by the Bill and Melinda Gates Foundation, BBSRC, MRC, AstraZeneca, National Institutes of Health (NIH), and the Canadian Institutes of Health Research (CIHR). He is on the editorial board for the journal Microbiome and sits on numerous expert panels relating to the gut microbiota.
Blog article: http://wwwf.imperial.ac.uk/blog/imperial-medicine/2019/05/28/think-small-solving-the-global-challenge-of-malnutrition-by-looking-at-metabolites/
Current lab members:
Gordana Panic (post-doctoral research associate)
Natasa Giallourou (post-doctoral research associate)
Fahmina Fardus-Reid (post-doctoral research associate)
Adesola Bello (PhD student)
Marine Letertre (PhD student)
Yi Yang (PhD student)
Giorgia Caspani (PhD student)
Simone Zuffa (PhD student)
et al., 2020, Maternal exposure to a human relevant mixture of persistent organic pollutants reduces colorectal carcinogenesis in A/J Min/+ mice, Chemosphere, Vol:252, ISSN:0045-6535
et al., 2020, Metabolic maturation in the first 2 years of life in resource-constrained settings and its association with postnatal growths, Science Advances, Vol:6, ISSN:2375-2548, Pages:1-10
et al., 2020, Considerations for the design and conduct of human gut microbiota intervention studies relating to foods, European Journal of Nutrition, ISSN:0044-264X
et al., 2020, Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy, Proceedings of the National Academy of Sciences, Vol:https://www.pnas.org/content/117/13/7374, ISSN:0027-8424, Pages:7374-7381
et al., 2020, Faecal virome transplantation decreases symptoms of type 2 diabetes and obesity in a murine model, Gut, ISSN:0017-5749