Dr Swann is a Reader (Associate Professor) in Microbiomics and Human Development within the Division of Integrative Systems Medicine and Digestive Diseases in the Department of Surgery and Cancer. Dr Swann is responsible for leading a metabonomic-based research programme to understand the influence of gene-environment interactions on the mammalian metabolic system and their implications for health and disease. His primary interests fall under two intersecting research themes:
(1) Role of the gut microbiota (the collection of microbes residing in the gastrointestinal tract) in the mammalian metabolic system and their association with host health and disease. This includes their contribution to host endogenous and xenobiotic metabolism, the gut-brain axis and its role in neurological disorders, the carcinogenic potential of the microbiome, and environmental and host factors shaping the acquisition and composition of the gut microbiome.
(2) Impact of early-life events and exposures on mammalian development particularly microbial-host interplay, metabolism, and phenotypic outcomes. A key research area is the application of metabolic phenotyping to the field of global health. Specifically, using a metabonomic approach to characterise the biochemical consequences of undernutrition and infection in children from developing countries to better understand the contributors to the long-term sequelae of early life undernutrition, including impaired cognitive, growth and metabolic functions.
Dr Swann’s research is supported by the Bill and Melinda Gates Foundation, BBSRC, MRC, AstraZeneca, National Institutes of Health (NIH), and the Canadian Institutes of Health Research (CIHR). He is on the editorial board for the journal Microbiome and sits on numerous expert panels relating to the gut microbiota.
Blog article: http://wwwf.imperial.ac.uk/blog/imperial-medicine/2019/05/28/think-small-solving-the-global-challenge-of-malnutrition-by-looking-at-metabolites/
Current lab members:
Gordana Panic (post-doctoral research associate)
Natasa Giallourou (post-doctoral research associate)
Fahmina Fardus-Reid (post-doctoral research associate)
Adesola Bello (PhD student)
Marine Letertre (PhD student)
Yi Yang (PhD student)
Giorgia Caspani (PhD student)
Simone Zuffa (PhD student)
et al., Targeted inhibition of gut bacterial β-glucuronidase activity enhances anticancer drug efficacy, Proceedings of the National Academy of Sciences, ISSN:0027-8424, Pages:201918095-201918095
et al., 2020, Effects of improved water, sanitation, and hygiene and improved complementary feeding on environmental enteric dysfunction in children in rural Zimbabwe: A cluster-randomized controlled trial., Plos Neglected Tropical Diseases, Vol:14, ISSN:1935-2727, Pages:1-29
et al., 2019, Characterizing the metabolic perturbations induced by activity-based anorexia in the C57Bl/6 mouse using 1H NMR spectroscopy., Clin Nutr
et al., 2019, Penalized regression models to select biomarkers of environmental enteric dysfunction associated with linear growth acquisition in a Peruvian birth cohort, Plos Neglected Tropical Diseases, Vol:13, ISSN:1935-2727
et al., 2019, Gut microbial metabolites in depression: understanding the biochemical mechanisms, Microbial Cell, Vol:6, ISSN:2311-2638, Pages:454-481