Imperial College London
Alternate

DrJonathanSwann

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 0728j.swann

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Johanson:2020:10.1016/j.chemosphere.2020.126484,
author = {Johanson, SM and Swann, JR and Umu, ÖCO and Aleksandersen, M and Müller, MHB and Berntsen, HF and Zimmer, KE and Østby, GC and Paulsen, JE and Ropstad, E},
doi = {10.1016/j.chemosphere.2020.126484},
journal = {Chemosphere},
title = {Maternal exposure to a human relevant mixture of persistent organic pollutants reduces colorectal carcinogenesis in A/J Min/+ mice},
url = {http://dx.doi.org/10.1016/j.chemosphere.2020.126484},
volume = {252},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - An increased risk of developing colorectal cancer has been associated with exposure to persistent organic pollutants (POPs) and alteration in the gut bacterial community. However, there is limited understanding about the impact of maternal exposure to POPs on colorectal cancer and gut microbiota. This study characterized the influence of exposure to a human relevant mixture of POPs during gestation and lactation on colorectal cancer, intestinal metabolite composition and microbiota in the A/J Min/+ mouse model. Surprisingly, the maternal POP exposure decreased colonic tumor burden, as shown by light microscopy and histopathological evaluation, indicating a restriction of colorectal carcinogenesis. 1H nuclear magnetic resonance spectroscopy-based metabolomic analysis identified alterations in the metabolism of amino acids, lipids, glycerophospholipids and energy in intestinal tissue. In addition, 16S rRNA sequencing of gut microbiota indicated that maternal exposure modified fecal bacterial composition. In conclusion, the results showed that early-life exposure to a mixture of POPs reduced colorectal cancer initiation and promotion, possibly through modulation of the microbial and biochemical environment. Further studies should focus on the development of colorectal cancer after combined maternal and dietary exposures to environmentally relevant low-dose POP mixtures.
AU  - Johanson,SM
AU  - Swann,JR
AU  - Umu,ÖCO
AU  - Aleksandersen,M
AU  - Müller,MHB
AU  - Berntsen,HF
AU  - Zimmer,KE
AU  - Østby,GC
AU  - Paulsen,JE
AU  - Ropstad,E
DO  - 10.1016/j.chemosphere.2020.126484
PY  - 2020///
SN  - 0045-6535
TI  - Maternal exposure to a human relevant mixture of persistent organic pollutants reduces colorectal carcinogenesis in A/J Min/+ mice
T2  - Chemosphere
UR  - http://dx.doi.org/10.1016/j.chemosphere.2020.126484
UR  - https://www.sciencedirect.com/science/article/pii/S0045653520306779?via%3Dihub
UR  - http://hdl.handle.net/10044/1/78530
VL  - 252
ER  -
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