Imperial College London
Alternate

DrJonathanSwann

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
//

Contact

 

+44 (0)20 7594 0728j.swann

 
 
//

Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Darzi:2015:10.1016/j.appet.2015.12.011,
author = {Darzi, J and Frost, GS and Swann, JR and Costabile, A and Robertson, MD},
doi = {10.1016/j.appet.2015.12.011},
journal = {Appetite},
pages = {142--149},
title = {l-rhamnose as a source of colonic propionate inhibits insulin secretion but does not influence measures of appetite or food intake.},
url = {http://dx.doi.org/10.1016/j.appet.2015.12.011},
volume = {98},
year = {2015}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Activation of free fatty acid receptor (FFAR)2 and FFAR3 via colonic short-chain fatty acids, particularly propionate, are postulated to explain observed inverse associations between dietary fiber intake and body weight. Propionate is reported as the predominant colonic fermentation product from l-rhamnose, a natural monosaccharide that resists digestion and absorption reaching the colon intact, while effects of long-chain inulin on appetite have not been extensively investigated. In this single-blind randomized crossover study, healthy unrestrained eaters (n = 13) ingested 25.5 g/d l-rhamnose, 22.4 g/d inulin or no supplement (control) alongside a standardized breakfast and lunch, following a 6-d run-in to investigate if appetite was inhibited. Postprandial qualitative appetite, breath hydrogen, and plasma glucose, insulin, triglycerides and non-esterified fatty acids were assessed for 420 min, then an ad libitum meal was provided. Significant treatment x time effects were found for postprandial insulin (P = 0.009) and non-esterified fatty acids (P = 0.046) with a significantly lower insulin response for l-rhamnose (P = 0.023) than control. No differences between treatments were found for quantitative and qualitative appetite measures, although significant treatment x time effects for meal desire (P = 0.008) and desire to eat sweet (P = 0.036) were found. Breath hydrogen was significantly higher with inulin (P = 0.001) and l-rhamnose (P = 0.009) than control, indicating colonic fermentation. These findings suggest l-rhamnose may inhibit postprandial insulin secretion, however neither l-rhamnose or inulin influenced appetite.
AU  - Darzi,J
AU  - Frost,GS
AU  - Swann,JR
AU  - Costabile,A
AU  - Robertson,MD
DO  - 10.1016/j.appet.2015.12.011
EP  - 149
PY  - 2015///
SN  - 1095-8304
SP  - 142
TI  - l-rhamnose as a source of colonic propionate inhibits insulin secretion but does not influence measures of appetite or food intake.
T2  - Appetite
UR  - http://dx.doi.org/10.1016/j.appet.2015.12.011
VL  - 98
ER  -
Download