Imperial College London
Alternate

DrJonathanSwann

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 0728j.swann

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Omairi:2016:10.7554/eLife.16940.001,
author = {Omairi, S and Matsakas, A and Degens, H and Kretz, O and Hansson, K and Vavang, Solbra A and Bruusgaard, J and Joch, B and Sartori, R and Giallourou, N and Mitchell, R and Collins-Hooper, H and Foster, K and Pasternack, A and Ritvos, O and Sandri, M and Narkar, V and Swann, JR and Huber, T and Patel, K},
doi = {10.7554/eLife.16940.001},
journal = {eLife},
title = {Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres},
url = {http://dx.doi.org/10.7554/eLife.16940.001},
volume = {5},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - A central tenet of skeletal muscle biology is the existence of an inverse relationship between the oxidative fibre capacity and its size. However, robustness of this relationship is unknown. We show that superimposition of Estrogen-related receptor gamma (Errγ) on the myostatin (Mtn) mouse null background (Mtn-/-/ErrγTg/+) results in hypertrophic muscle with a high oxidative capacity thus violating the inverse relationship between fibre size and oxidative capacity. We also examined the canonical view that oxidative muscle phenotype positively correlate with Satellite cell number, the resident stem cells of skeletal muscle. Surprisingly, hypertrophic fibres from Mtn-/-/ErrγTg/+ mouse showed satellite cell deficit which unexpectedly did not affect muscle regeneration. These observations 1) challenge the concept of a constraint between fibre size and oxidative capacity and 2) indicate the important role of the microcirculation in the regenerative capacity of a muscle even when satellite cell numbers are reduced.
AU  - Omairi,S
AU  - Matsakas,A
AU  - Degens,H
AU  - Kretz,O
AU  - Hansson,K
AU  - Vavang,Solbra A
AU  - Bruusgaard,J
AU  - Joch,B
AU  - Sartori,R
AU  - Giallourou,N
AU  - Mitchell,R
AU  - Collins-Hooper,H
AU  - Foster,K
AU  - Pasternack,A
AU  - Ritvos,O
AU  - Sandri,M
AU  - Narkar,V
AU  - Swann,JR
AU  - Huber,T
AU  - Patel,K
DO  - 10.7554/eLife.16940.001
PY  - 2016///
SN  - 2050-084X
TI  - Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.16940.001
UR  - http://hdl.handle.net/10044/1/38805
VL  - 5
ER  -
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