Imperial College London
Alternate

DrJonathanSwann

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 7594 0728j.swann

 
 
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Location

 

660Sir Alexander Fleming BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Grimaldi:2016:femsec/fiw233,
author = {Grimaldi, R and Cela, D and Swann, JR and Vulevic, J and Gibson, GR and Tzortzis, G and Costabile, A},
doi = {femsec/fiw233},
journal = {FEMS Microbiology Ecology},
title = {In vitro  fermentation of B-GOS: impact on faecal bacterial populations and metabolic activity in autistic and non-autistic children},
url = {http://dx.doi.org/10.1093/femsec/fiw233},
volume = {93},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Children with autism spectrum disorders (ASD) often suffer gastrointestinal problems consistent with imbalances in the gut microbial population. Treatment with antibiotics or pro/prebiotics has been postulated to regulate microbiota and improve gut symptoms, but there is a lack of evidence for such approaches, especially for prebiotics. This study assessed the influence of a prebiotic galactooligosaccharide (B-GOS) on gut microbial ecology and metabolic function using faecal samples from autistic and non-autistic children in an in vitro gut model system. Bacteriology was analysed using flow cytometry combined with fluorescence in situ hybridization and metabolic activity by HPLC and 1H-NMR. Consistent with previous studies, the microbiota of children with ASD contained a higher number of Clostridium spp. and a lower number of bifidobacteria compared with non-autistic children. B-GOS administration significantly increased bifidobacterial populations in each compartment of the models, both with autistic and non-autistic-derived samples, and lactobacilli in the final vessel of non-autistic models. In addition, changes in other bacterial population have been seen in particular for Clostridium, Rosburia, Bacteroides, Atopobium, Faecalibacterium prausnitzii, Sutterella spp. and Veillonellaceae. Furthermore, the addition of B-GOS to the models significantly altered short-chain fatty acid production in both groups, and increased ethanol and lactate in autistic children.
AU  - Grimaldi,R
AU  - Cela,D
AU  - Swann,JR
AU  - Vulevic,J
AU  - Gibson,GR
AU  - Tzortzis,G
AU  - Costabile,A
DO  - femsec/fiw233
PY  - 2016///
SN  - 0168-6496
TI  - In vitro  fermentation of B-GOS: impact on faecal bacterial populations and metabolic activity in autistic and non-autistic children
T2  - FEMS Microbiology Ecology
UR  - http://dx.doi.org/10.1093/femsec/fiw233
UR  - http://hdl.handle.net/10044/1/49170
VL  - 93
ER  -
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