Publications

BibTex format

@article{Shortt:2018:10.1007/s00394-017-1546-4,
author = {Shortt, C and Hasselwander, O and Meynier, A and Nauta, A and Fernández, EN and Putz, P and Rowland, I and Swann, J and Türk, J and Vermeiren, J and Antoine, J-M},
doi = {10.1007/s00394-017-1546-4},
journal = {European Journal of Nutrition},
pages = {25--49},
title = {Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients},
url = {http://dx.doi.org/10.1007/s00394-017-1546-4},
volume = {57},
year = {2018}
}

Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - PurposeThere is considerable interest in the effects of the intestinal microbiota (IM) composition, its activities in relation with the metabolism of dietary substrates and the impact these effects may have in the development and prevention of certain non-communicable diseases. It is acknowledged that a complex interdependence exists between the IM and the mammalian host and that the IM possesses a far greater diversity of genes and repertoire of metabolic and enzymatic capabilities than their hosts. However, full knowledge of the metabolic activities and interactions of the IM and the functional redundancy that may exist are lacking. Thus, the current review aims to assess recent literature relating to the role played by the IM in the absorption and metabolism of key nutrients and non-nutrients.MethodsA systematic review (PROSPERO registration: CRD42015019087) was carried out focussing on energy and the following candidate dietary substrates: protein, carbohydrate, fat, fibre, resistant starch (RS), and polyphenols to further understand the effect of the IM on the dietary substrates and the resulting by-products and host impacts. Particular attention was paid to the characterisation of the IM which are predominantly implicated in each case, changes in metabolites, and indirect markers and any potential impacts on the host.ResultsStudies show that the IM plays a key role in the metabolism of the substrates studied. However, with the exception of studies focusing on fibre and polyphenols, there have been relatively few recent human studies specifically evaluating microbial metabolism. In addition, comparison of the effects of the IM across studies was difficult due to lack of specific analysis/description of the bacteria involved. Considerable animal-derived data exist, but experience suggests that care must be taken when extrapolating these results to humans. Nevertheless, it appears that the IM plays a role in energy homeostasis and that protein microbial breakdown
AU  - Shortt,C
AU  - Hasselwander,O
AU  - Meynier,A
AU  - Nauta,A
AU  - Fernández,EN
AU  - Putz,P
AU  - Rowland,I
AU  - Swann,J
AU  - Türk,J
AU  - Vermeiren,J
AU  - Antoine,J-M
DO  - 10.1007/s00394-017-1546-4
EP  - 49
PY  - 2018///
SN  - 0044-264X
SP  - 25
TI  - Systematic review of the effects of the intestinal microbiota on selected nutrients and non-nutrients
T2  - European Journal of Nutrition
UR  - http://dx.doi.org/10.1007/s00394-017-1546-4
UR  - http://hdl.handle.net/10044/1/54914
VL  - 57
ER  -

Download

DrJonathanSwann

Contact

Location

Summary

Citation

BibTex format

RIS format (EndNote, RefMan)