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@article{Costabile:2017:10.1371/journal.pone.0187964,
author = {Costabile, A and Buttarazzi, I and Kolida, S and Quercia, S and Baldini, J and Swann, JR and Brigidi, P and Gibson, G},
doi = {10.1371/journal.pone.0187964},
journal = {PLoS ONE},
title = {An in vivo assessment of the cholesterol-lowering efficacy of Lactobacillus plantarum ECGC 13110402 in normal to mildly hypercholesterolaemic adults},
url = {http://dx.doi.org/10.1371/journal.pone.0187964},
volume = {12},
year = {2017}
}

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TY  - JOUR
AB  - Coronary heart disease (CHD) is one of the major causes of death and disability in industrialised countries, with elevated blood cholesterol an established risk factor. Total plasma cholesterol reduction in populations suffering from primary hypercholesterolemia may lower CHD incidence. This study investigated the cholesterol reducing capacity of Lactobacillus plantarum ECGC 13110402, a strain selected for its high bile salt hydrolase activity, in 49 normal to mildly hypercholesterolaemic adults. Primary efficacy outcomes included effect on blood lipids (total cholesterol (TC), low density lipoproteins (LDL-C), high density lipoproteins (HDL-C) and triacylgycerides (TAG), inflammatory biomarkers and occurrence/severity of gastrointestinal side effects to establish safety and tolerance of the intervention. Secondary outcomes included blood pressure, immune biomarkers, gut microbiota characterisation and metabonome changes. The study was run in a parallel, double blind, placebo controlled, randomised design in which the active group ingested 2x109 CFU encapsulated Lactobacillus plantarum ECGC 13110402 twice daily. Daily ingestion of the active treatment resulted in a statistically significant reduction in LDL-C in volunteers with baseline TC<5mM during the 0–12 week period (13.9%, P = 0.030), a significant reduction in TC in volunteers with baseline TC≥6mM in the 0–6 week period (37.6%, P = 0.045), a significant decrease in TAG (53.9% P = 0.030) and an increase in HDL-C (14.7%, P = 0.007) in the over 60 years population in the 6–12 week period. A statistically significant reduction in systolic blood pressure was also observed across the active study group in the 6-12-week period (6.6%, P = 0.003). No impact on gastrointestinal function and side effects was observed during the study. Similar to blood and urine metabonomic analyses, faecal metagenomics did not reveal significant changes upon active or placebo intake. The results of this study sug
AU  - Costabile,A
AU  - Buttarazzi,I
AU  - Kolida,S
AU  - Quercia,S
AU  - Baldini,J
AU  - Swann,JR
AU  - Brigidi,P
AU  - Gibson,G
DO  - 10.1371/journal.pone.0187964
PY  - 2017///
SN  - 1932-6203
TI  - An in vivo assessment of the cholesterol-lowering efficacy of Lactobacillus plantarum ECGC 13110402 in normal to mildly hypercholesterolaemic adults
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0187964
UR  - http://hdl.handle.net/10044/1/56001
VL  - 12
ER  -

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