Clinical Research Fellow for PRECEPT STUDY
The PRECEPT study's aim is to assess maternal cardiovascular changes in established uteroplacental insufficiency. The study recruits women after 24 weeks gestation whose pregnancies are affected by pre-eclampsia and/or fetal growth restriction and women with normal pregnancies and compares their cardiovascular status, namely cardiac output, augmentation index, pulse wave velocity, peripheral vascular resistance and central blood pressure from diagnosis until post-delivery, to characterize changes in relation to time of diagnosis and therapy whilst assessing fetal circulatory changes using Doppler. The metabonomic and cardiovascular biomarker profiles will be investigated in relation to maternal cardiovascular function.
Funding for this study is provided by Imperial College NHS Trust and Imperial College Healthcare Charities for Dr Jasmine Tay. The project is a collaboration with the Department of Clinical Pharmacology, Cambridge University.
Santhirakumaran S, Tay J, Lees C, 2019, The relationship between maternal characteristics and carotid intima-media thickness using an automated ultrasound technique, Hypertension in Pregnancy, Vol:38, ISSN:1064-1955, Pages:252-259
Tay J, Lees C, 2019, RE: Tay et al, Uterine and fetal placental Doppler indices are associated with maternal cardiovascular function, American Journal of Obstetrics and Gynecology, Vol:221, ISSN:0002-9378, Pages:291-292
et al., 2019, Methods and considerations concerning cardiac output measurement in pregnant women: recommendations of the International Working Group on Maternal Hemodynamics, Ultrasound in Obstetrics and Gynecology, Vol:54, ISSN:0960-7692, Pages:35-50
et al., 2019, Cardiac output changes from prior to pregnancy to post partum using two non-invasive techniques, Heart, Vol:105, ISSN:1355-6037, Pages:715-720
et al., 2019, Selective reduction in complex triplet pregnancy by radiofrequency ablation: single-centre experience, RCOG world congress 2019, WILEY, Pages:52-53, ISSN:1470-0328