Imperial College London
Alternate

Professor Julian Teare

Faculty of Medicine, Department of Surgery & Cancer

Emeritus Professor
 
 
 
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Contact

 

+44 (0)20 3312 1072j.teare

 
 
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Location

 

CL3 026St Marys Multiple BuildingsSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Penny:2016:10.1016/j.dld.2016.02.009,
author = {Penny, HA and Mooney, PD and Burden, M and Patel, N and Johnston, AJ and Wong, SH and Teare, J and Sanders, DS},
doi = {10.1016/j.dld.2016.02.009},
journal = {Digestive and Liver Disease},
pages = {644--649},
title = {High definition endoscopy with or without I-Scan increases the detection of celiac disease during routine endoscopy},
url = {http://dx.doi.org/10.1016/j.dld.2016.02.009},
volume = {48},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND AND AIMS: Celiac disease remains underdiagnosed at endoscopy. We aimed to assess the utility of I-Scan (virtual chromo-endoscopy) to improve sensitivity of endoscopy to detect markers of villous atrophy in this condition. METHODS: Patients from 2 UK hospitals were studied in 3 groups. Group 1: standard high definition, white light endoscopy (WLE); Group 2: WLE plus I-Scan; Group 3: non-high definition control group. The presence of endoscopic markers was recorded. At least 4 duodenal biopsies were taken from all patients. Serology was performed concurrently and observations were compared with histology. RESULTS: 758 patients (62% female, mean age 52) were recruited (Group 1: 230; Group 2: 228; Group 3: 300). 135 (17.8%) new diagnoses of coeliac disease were made (21 Group 1; 24 Group 2; 89 Group 3). The sensitivity for detection of endoscopic markers of villous atrophy was significantly higher in both Group 1 (85.7%, p=0.0004) and Group 2 (75%, p=0.005) compared to non-high definition controls (41.6%). There was no significant difference between high definition only and I-Scan groups (p=0.47). In non-high definition endoscopy a missed diagnosis was associated with lesser degrees of villous atrophy (p=0.019) and low tTG titre (p=0.007). CONCLUSIONS: High definition endoscopy with or without I-Scan increases the detection of celiac disease during routine endoscopy.
AU  - Penny,HA
AU  - Mooney,PD
AU  - Burden,M
AU  - Patel,N
AU  - Johnston,AJ
AU  - Wong,SH
AU  - Teare,J
AU  - Sanders,DS
DO  - 10.1016/j.dld.2016.02.009
EP  - 649
PY  - 2016///
SN  - 1878-3562
SP  - 644
TI  - High definition endoscopy with or without I-Scan increases the detection of celiac disease during routine endoscopy
T2  - Digestive and Liver Disease
UR  - http://dx.doi.org/10.1016/j.dld.2016.02.009
VL  - 48
ER  -
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