Imperial College London
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DrJanVollert

Faculty of Medicine, Department of Surgery & Cancer

Honorary Lecturer
 
 
 
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Contact

 

j.vollert

 
 
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Location

 

Chelsea and Westminster HospitalChelsea and Westminster Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rocha:2018,
author = {Rocha, TM and Pimenta, S and Bernardo, A and Bernardes, M and Barbosa, M and Lucas, R and Vollert, J and Costa, L and Maier, C},
journal = {Acta Reumatologica Portuguesa},
pages = {291--303},
title = {Determinants of non-nociceptive pain in Rheumatoid Arthritis},
volume = {2018},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - © 2001-2019 Sociedade Portuguesa de Reumatologia. Introduction: Features suggestive of neuropathic pain (NP) have been described in rheumatoid arthritis (RA) in addition to nociceptive pain. We aimed to determine the clinical predictors of NP in RA patients and study its association with radiographic structural damage. Methods: Cross-sectional study was performed with RA patients followed at our Rheumatology department. Patients with diagnosed neuropathy of other origin, non-RA related risk factors for NP (e.g. diabetes mellitus) or fibromyalgia, according to expert opinion, were excluded. Demographic and clinical data were collec ted and disease activity/functional measures were evalua - ted. Two questionnaires were applied to assess NP: the Leeds Assessment of Neuropathic Symptoms (LANSS) and the painDETECT questionnaire (PDQ). Radiographs performed in up to 12 months before/after the evaluation were classified according to the modified van der Heijde Sharp's method. Univariate and multivariate logistic regression were performed to identify the predictors of NP. Results: 112 patients were included. 86 (77%) were women, with a mean (SD) age of 55.1 (10.8) years and median disease duration of 13 [2-41] years. 45 (40%) patients had NP by the LANSS (≥12) and 28% had a possible/likely NP in the PDQ (≥13). Female sex was predictive of NP by both tests and disease duration was inversely associated with LANSS NP. After adjusting for those two variables, pain Visual Analog Scale (VAS) and TJC were positive predictors of NP by both tests. The same was not true for SJC, ESR or CRP levels. DAS28-CRP was significantly associated with PDQ NP, losing its statistical significance after adjustment for TJC and pain VAS. The HAQ score increased the odds of NP for both tests, independently of DAS 28-CRP. Posi - tivity for ACPA and previous/current hydroxychloroquine treatment had lower odds of NP. 90 patients performed radiographic evaluation. Joint narrowing score was a s
AU  - Rocha,TM
AU  - Pimenta,S
AU  - Bernardo,A
AU  - Bernardes,M
AU  - Barbosa,M
AU  - Lucas,R
AU  - Vollert,J
AU  - Costa,L
AU  - Maier,C
EP  - 303
PY  - 2018///
SN  - 0303-464X
SP  - 291
TI  - Determinants of non-nociceptive pain in Rheumatoid Arthritis
T2  - Acta Reumatologica Portuguesa
VL  - 2018
ER  -
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