ProfessorJonathanWeber

Frater AJ, Galpin S, Beardall A, Clarke JR, Ariyoshi K, Weber JN, McClure MOet al., 2000, Baseline polymorphisms found in patients infected with non-clade BHIV-1 do not affect outcome to HAART, AIDS, Vol: 14, Pages: S114-S114, ISSN: 0269-9370

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Stainsby CM, Lyall EGH, Taylor GP, Galpin S, Clarke JR, McClure MO, Weber JNet al., 2000, A significant number of uninfected infants can be HIV RNA (false) pos-positive, AIDS, Vol: 14, Pages: S106-S106, ISSN: 0269-9370

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Clarke JR, Kaye S, Babiker AG, Hooker MH, Tedder R, Weber JNet al., 2000, Comparison of a point mutation assay with a line probe assay for the detection of the major mutations in the HIV-1 reverse transcriptase gene associated with reduced susceptibility to nucleoside analogues, JOURNAL OF VIROLOGICAL METHODS, Vol: 88, Pages: 117-124, ISSN: 0166-0934

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• Citations: 7

Frater AJ, Chaput CC, Weber JN, McClure MOet al., 2000, HIV-1 resistance genotyping by sequencing produces inconsistent results for mixed viral populations, AIDS, Vol: 14, Pages: 1473-1475, ISSN: 0269-9370

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• Citations: 9

Ades AE, Parker S, Walker J, Weber JNet al., 2000, Serotype, parental country of birth, and ethnic status in unlinked anonymous neonatal HIV seroprevalence surveys, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 24, Pages: 292-294, ISSN: 1525-4135

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• Citations: 2

Ades AE, Parker S, Walker J, Edginton M, Taylor GP, Weber JNet al., 2000, Human T cell leukaemia/lymphoma virus infection in pregnant women in the United Kingdom: population study, BRITISH MEDICAL JOURNAL, Vol: 320, Pages: 1497-1501, ISSN: 0959-8138

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• Citations: 35

Kaleebu P, Yirrell D, French N, Lyagoba F, Rutebemberwa A, Cheingsong-Popov R, Gilks C, Biryahwaho B, Weber J, Whitworth Jet al., 2000, An improved algorithm for determining HIV type 1 subtypes in a primary laboratory in Uganda, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 16, Pages: 621-625, ISSN: 0889-2229

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• Citations: 13

Furukawa Y, Bangham CRM, Taylor GP, Weber JN, Osame Met al., 2000, Frequent reversible membrane damage in peripheral blood B cells in human T cell lymphotropic virus type I (HTLV-I)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Vol: 120, Pages: 307-316, ISSN: 0009-9104

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• Citations: 19

Van Damme L, Wright A, Depraetere K, Rosenstein I, Vandersmissen V, Poulter L, McKinlay M, Van Dyck E, Weber J, Profy A, Laga M, Kitchen Vet al., 2000, A phase I study of a novel potential intravaginal microbicide, PRO 2000, in healthy sexually inactive women, SEXUALLY TRANSMITTED INFECTIONS, Vol: 76, Pages: 126-130, ISSN: 1368-4973

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• Citations: 94

Hanon E, Hall S, Taylor GP, Saito M, Davis R, Tanaka Y, Usuku K, Osame M, Weber JN, Bangham CRMet al., 2000, Abundant Tax protein expression in CD4+T cells infected with HTLV-I is prevented by cytotoxic T lymphocytes, LEUKEMIA, Vol: 14, Pages: 547-547, ISSN: 0887-6924

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Hanon E, Hall S, Taylor GP, Saito M, Davis R, Tanaka Y, Usuku K, Osame M, Weber JN, Bangham CRMet al., 2000, Abundant Tax protein expression in CD4+T cells infected with human T-cell lymphotropic virus type I (HTLV-I) is prevented by cytotoxic T lymphocytes, BLOOD, Vol: 95, Pages: 1386-1392, ISSN: 0006-4971

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• Citations: 226

Bobkov AF, Lukashov V, Goudsmit J, Weber JNet al., 2000, Silent mutation in the V3 region characteristic of HIV type 1 <i>env</i> subtype B strains from injecting drug users in the former Soviet Union, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 16, Pages: 291-294, ISSN: 0889-2229

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• Citations: 5

Fidler S, Weber J, 2000, T-cell activation: a cellular target for antiretroviral therapy, EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, Vol: 30, Pages: 95-98, ISSN: 0014-2972

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• Citations: 2

Ainsworth JG, Hourshid S, Easterbrook PJ, Gilroy CB, Weber JN, Taylor-Robinson Det al., 2000, <i>Mycoplasma</i> species in rapid and slow HIV progressors, INTERNATIONAL JOURNAL OF STD & AIDS, Vol: 11, Pages: 76-79, ISSN: 0956-4624

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• Citations: 4

McCormack S, Tilzey A, Carmichael A, Gotch F, Kepple J, Newberry A, Jones G, Lister S, Beddows S, Cheingsong R, Rees A, Babiker A, Banatvala J, Bruck C, Darbyshire J, Tyrrell D, Van Hoecke C, Weber Jet al., 2000, A phase I trial in HIV negative healthy volunteers evaluating the effect of potent adjuvants on immunogenicity of a recombinant gp120_W61D derived from dual tropic R5X4 HIV-1_ACH320, VACCINE, Vol: 18, Pages: 1166-1177, ISSN: 0264-410X

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• Citations: 47

Clarke JR, White NC, Weber JN, 2000, HIV compartmentalization: Pathogenesis and clinical implications, AIDS Reviews, Vol: 2, Pages: 15-22, ISSN: 1139-6121

Infection with HIV results in the dissemination of the virus to a number of target compartments which may act as sanctuary sites for the virus. Sanctuary sites for HIV may be divided into cellular and anatomical sites. Cellular sites for HIV include both productively and latently infected CD4+ lymphocytes, macrophages and dendritic cells while anatomical sites include blood, lymph nodes, central nervous system (CNS), genital tract, spleen and lung. Some of these sites may be inaccessible to some classes of antiretroviral drugs e.g. some protease inhibitors penetrate poorly into the CNS and genital tract. Mathematical models have been used to predict the importance of sanctuary sites and trafficking of virus between compartments on the pathogenesis of HIV infection. This review will discuss recent understanding of the role of sanctuary sites in the persistence of HIV in the host.

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• Citations: 9

Hanon E, Stinchcombe JC, Saito M, Asquith BE, Taylor GP, Tanaka Y, Weber JN, Griffiths GM, Bangham CRMet al., 2000, Fracticide among CD8⁺ T lymphocytes naturally infected with human T cell lymphotropic virus type I, Immunity, Vol: 13, Pages: 657-664, ISSN: 1074-7613

Infection and gene expression by the human T lymphotropic virus type I (HTLV-I) in vivo have been thought to be confined to CD4+ T lymphocytes. We show here that, in natural HTLV-I infection, a significant proportion of CD8+ T lymphocytes are infected by HTLV-I. Interestingly, HTLV-I-specific but not Epstein-Barr virus-specific CD8+ T lymphocytes were shown to be infected. Furthermore, HTLV-I protein expression in naturally infected CD8+ T lymphocytes renders them susceptible to fratricide mediated by autologous HTLV-I-specific CD8+ T lymphocytes. Fratricide among virus-specific CTLs could impair the immune control of HTLV-I and possibly other lymphotropic viruses.

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• Citations: 158

Bobkov AF, Kazennova EV, Selimova LM, Khanina TA, Bobkova MR, Ladnaia NN, Kravchenko AV, Pokrovskiĭ VV, Weber JNet al., 2000, [Nucleotide sequence of gag and env genes of human immunodeficiency virus type 1, found in Russia: detection of new recombinant variants]., Vopr Virusol, Vol: 45, Pages: 17-20, ISSN: 0507-4088

Phylogenetic analysis of nucleotide sequences of gag and env genes of type 1 human immunodeficiency virus (HIV-1) variants isolated from individuals infected through sexual intercourse or nosocomially (by injections with nonsterile syringes) showed that 5 of 27 (18.5%) isolated strains were recombinants. Two viruses found in the Russian Far East had gagAenvE genotype, three other recombinants had envG genotype; gag gene of one isolate belonged to subtype A and gag genes of two others belonged to subtype D. Detection of new recombinant variants in addition to the A/B recombinant described previously shows that these viruses can contribute to the HIV-1 genetic variability in Russia.

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Gilson RJC, Shupack JL, Friedman-Kien AE, Conant MA, Weber JN, Nayagam AT, Swann RV, Pietig DC, Smith MH, Owens MLet al., 1999, A randomized, controlled, safety study using imiquimod for the topical treatment of anogenital warts in HIV-infected patients, AIDS, Vol: 13, Pages: 2397-2404, ISSN: 0269-9370

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• Citations: 65

Taylor GP, Hall SE, Navarrete S, Michie CA, Davis R, Witkover AD, Rossor M, Nowak MA, Rudge P, Matutes E, Bangham CRM, Weber JNet al., 1999, Effect of lamivudine on human T-cell leukemia virus type 1 (HTLV-1) DNA copy number, T-cell phenotype, and anti-tax cytotoxic T-cell frequency in patients with HTLV-1-associated myelopathy, JOURNAL OF VIROLOGY, Vol: 73, Pages: 10289-10295, ISSN: 0022-538X

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• Citations: 97

Babiker AG, Darbyshire JH, Gazzard BG, Hooker MH, Kitchen V, Newberry A, Peto TE, Tedder R, Weber J, Breckenridge A, Back D, Blatchford N, Gartland M, Jeffries D, Johnson M, Plummer K, Wills B, Loveday C, Weller IVD, Withnall Ret al., 1999, A randomized trial comparing regimens of four reverse transcriptase inhibitors given together or cyclically in HIV-1 infection - The Quattro Trial, AIDS, Vol: 13, Pages: 2209-2217, ISSN: 0269-9370

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• Citations: 6

Clarke JR, Braganza R, Mirza A, Stainsby C, Ait-Khaled M, Wright A, Lyall H, Parker D, McClure MO, Weber JN, Taylor GPet al., 1999, Rapid development of genotypic resistance to lamivudine when combined with zidovudine in pregnancy, JOURNAL OF MEDICAL VIROLOGY, Vol: 59, Pages: 364-368, ISSN: 0146-6615

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• Citations: 30

Ward H, Day S, Weber J, 1999, Risky business: health and safety in the sex industry over a 9 year period, SEXUALLY TRANSMITTED INFECTIONS, Vol: 75, Pages: 340-343, ISSN: 1368-4973

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• Citations: 95

Churchill DR, Pym AS, Galpin S, Foxall R, Stainsby C, Clarke JR, Kaye S, Bloor S, Larder BA, Wills B, Sun E, Babiker AG, Back DJ, Weber JNet al., 1999, The rabbit study: Ritonavir and saquinavir in combination in saquinavir-experienced and previously untreated patients, AIDS RESEARCH AND HUMAN RETROVIRUSES, Vol: 15, Pages: 1181-1189, ISSN: 0889-2229

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• Citations: 6

Taylor GP, Tosswill JHC, Matutes E, Daenke S, Hall S, Bain BJ, Davis R, Thomas D, Rossor M, Bangham CRM, Weber JNet al., 1999, Prospective study of HTLV-I infection in an initially asymptomatic cohort, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 22, Pages: 92-100, ISSN: 1077-9450

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• Citations: 66

Louisirirotchanakul S, Beddows S, Cheingsong R, Shaffer N, Mastro TD, Likanonsakul S, Wasi C, Taylor GP, Weber JNet al., 1999, Role of maternal humoral immunity in vertical transmission of HIV-1 subtype E in Thailand, JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, Vol: 21, Pages: 259-265, ISSN: 1525-4135

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• Citations: 15

Babiker A, Darbyshire JH, Gill ON, Johnson AM, Phillips AN, Porter K, Beral V, Brettle R, Carne C, Gilson RJC, Goldberg D, Hawkins DA, Jeffries D, Johnson MA, McMichael AJ, Mortimer PP, Pozniak A, Weber J, Wellsteed Set al., 1999, How soon after HIV seroconversion is antiretroviral therapy initiated?, AIDS, Vol: 13, Pages: 1241-1247, ISSN: 0269-9370

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• Citations: 3

Kirchhoff F, Easterbrook PJ, Douglas N, Troop M, Greenough TC, Weber J, Carl S, Sullivan JL, Daniels RSet al., 1999, Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease, JOURNAL OF VIROLOGY, Vol: 73, Pages: 5497-5508, ISSN: 0022-538X

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• Citations: 96

Abrams D, Allan D, Antunes F, Breckenridge A, Bruun J, Cameron W, Carbon C, Chalmers I, Chang H, Chodakewitz J, Clendenin N, Clumeck N, Collier A, Collins G, Cooper E, Cooper D, Danner S, D'Aquila R, DeGruttola V, DeMasi R, Dee L, Deyton L, Dixon D, Farthing C, Feinberg J, Fischl M, Flepp M, Gartland M, Gatell J, Gazzard B, Goebel F, Gotzsche P, Gringeri A, Hall D, Hamilton J, Hammer S, Hartigan P, Heath-Chiozzi M, Henry K, Hill A, Hirschel B, Ioannidis J, Kahn J, Katlama C, Katzenstein D, Killen J, King E, de Loes SK, Kravcik S, Lange J, Leavitt R, Leonard J, Maeland A, Mannucci P, Mathiesen L, McDade H, Meibohn A, Melander H, Merigan T, Mulder J, Myers M, Neaton J, Nessling M, Perrin L, Pettinelli C, Phair J, Phillips A, Pinching A, Poppa A, Power L, Reiss P, Richman D, Rooney J, Rousseau F, Rutherford G, Salgo M, Sandstrom E, Saravolatz L, Savidge G, Schnittman S, Schooley R, Seligmann M, Simberkoff M, Skowron G, Slade P, Smith D, Smith RP, Soriano V, Stanley K, Stingl G, Stoffels P, Struthers L, Tierney C, Thompson M, Van der Broeck R, Van Leeuven R, Van Weverling G, Veenstra J, Vella S, Volberding P, Weber J, Winslow D, Yeni P, Yeo J, Dormont J, Sande M, Weller I, Babiker A, Collins R, Darbyshire J, Duncan W, Foulkes M, Hughes M, Peto R, Peto T, Walker Set al., 1999, Zidovudine, didanosine, and zalcitabine in the treatment of HIV infection: meta-analyses of the randomised evidence, LANCET, Vol: 353, Pages: 2014-2025, ISSN: 0140-6736

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• Citations: 32

Heeney JL, Beverley P, McMichael A, Shearer G, Strominger J, Wahren B, Weber J, Gotch Fet al., 1999, Immune correlates of protection from HIV and AIDS - more answers but yet more questions, IMMUNOLOGY TODAY, Vol: 20, Pages: 247-251, ISSN: 0167-5699

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• Citations: 39