Imperial College London
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ProfessorJonathanWeber

Faculty of Medicine, Department of Infectious Disease

Director of the AHSC, Professor of Communicable Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3905j.weber

 
 
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Assistant

 

Mrs Siobhan Pigott +44 (0)20 7594 3901

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zilber:2019:10.1097/QAD.0000000000002165,
author = {Zilber, E and Martin, GE and Willberg, CB and Fox, J and Nwokolo, N and Fidler, S and Frater, J and CHERUB, Investigators},
doi = {10.1097/QAD.0000000000002165},
journal = {AIDS},
pages = {1253--1256},
title = {Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection.},
url = {http://dx.doi.org/10.1097/QAD.0000000000002165},
volume = {33},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - : Soluble forms of the coinhibitory receptors programmed death 1 (PD-1) and Tim-3 exist, but their relationship with T-cell surface expression remains unclear. When measured by an enzyme-linked immunosorbent assay in plasma, soluble PD-1, and soluble Tim-3 were elevated during primary HIV infection, decreased on antiretroviral therapy to levels found in controls, and correlated with cell surface expression. We conclude that soluble PD-1 and soluble Tim-3 are easy to measure biomarkers of immune exhaustion which potentially eliminate the need for flow cytometry.
AU  - Zilber,E
AU  - Martin,GE
AU  - Willberg,CB
AU  - Fox,J
AU  - Nwokolo,N
AU  - Fidler,S
AU  - Frater,J
AU  - CHERUB,Investigators
DO  - 10.1097/QAD.0000000000002165
EP  - 1256
PY  - 2019///
SP  - 1253
TI  - Soluble plasma programmed death 1 (PD-1) and Tim-3 in primary HIV infection.
T2  - AIDS
UR  - http://dx.doi.org/10.1097/QAD.0000000000002165
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31045943
VL  - 33
ER  -
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