Imperial College London
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ProfessorJonathanWeber

Faculty of Medicine, Department of Infectious Disease

Director of the AHSC, Professor of Communicable Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3905j.weber

 
 
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Assistant

 

Mrs Siobhan Pigott +44 (0)20 7594 3901

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Stoehr:2013:10.1371/journal.pone.0078287,
author = {Stoehr, W and Fidler, S and McClure, M and Weber, J and Cooper, D and Ramjee, G and Kaleebu, P and Tambussi, G and Schechter, M and Babiker, A and Phillips, RE and Porter, K and Frater, J},
doi = {10.1371/journal.pone.0078287},
journal = {PLoS ONE},
title = {Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy},
url = {http://dx.doi.org/10.1371/journal.pone.0078287},
volume = {8},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: A minority of HIV-1 positive individuals treated with antiretroviral therapy (ART) in primary HIV-1 infection(PHI) maintain viral suppression on stopping. Whether this is related to ART duration has not been explored.Design: And Methods: Using SPARTAC trial data from individuals recruited within 6 months of seroconversion, wepresent an observational analysis investigating whether duration of ART was associated with post-treatment viraemiccontrol. Kaplan-Meier estimates, logistic regression and Cox models were used.Results: 165 participants reached plasma viral loads (VL) <400 copies/ml at the time of stopping therapy (ART stop).After ART stop, 159 experienced confirmed VL ≥400 copies/ml during median (IQR) follow-up of 167 (108,199)weeks.Most participants experienced VL rebound within 12 weeks from ART stop, however, there was a suggestion of ahigher probability of remaining <400 copies/ml for those on ART >12 weeks compared to ≤12 weeks (p=0.061).Cumulative probabilities of remaining <400 copies/ml at 12, 52 and 104 weeks after ART stop were 21%(95%CI=13,30), 4% (1,9), and 4% (1,9) for ≤12 weeks ART, and 32% (22,42), 14% (7,22), and 5% (2,11) for >12weeks.In multivariable regression, ART for >12 weeks was independently associated with a lower probability of being≥400 copies/ml within 12 weeks of ART stop (OR=0.11 (95%CI=0.03,0.34), p<0.001)). In Cox models of time to VL≥400 after 12 weeks, we only found an association with female sex (OR=0.2, p=0.001).Conclusion: Longer ART duration in PHI was associated with a higher probability of viral control after ART stop.
AU  - Stoehr,W
AU  - Fidler,S
AU  - McClure,M
AU  - Weber,J
AU  - Cooper,D
AU  - Ramjee,G
AU  - Kaleebu,P
AU  - Tambussi,G
AU  - Schechter,M
AU  - Babiker,A
AU  - Phillips,RE
AU  - Porter,K
AU  - Frater,J
DO  - 10.1371/journal.pone.0078287
PY  - 2013///
SN  - 1932-6203
TI  - Duration of HIV-1 Viral Suppression on Cessation of Antiretroviral Therapy in Primary Infection Correlates with Time on Therapy
T2  - PLoS ONE
UR  - http://dx.doi.org/10.1371/journal.pone.0078287
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326155400076&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - http://hdl.handle.net/10044/1/49831
VL  - 8
ER  -
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