Imperial College London
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ProfessorJonathanWeber

Faculty of Medicine, Department of Infectious Disease

Director of the AHSC, Professor of Communicable Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3905j.weber

 
 
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Assistant

 

Mrs Siobhan Pigott +44 (0)20 7594 3901

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Williams:2014:10.7554/eLife.03821,
author = {Williams, JP and Hurst, J and Stoehr, W and Robinson, N and Brown, H and Fisher, M and Kinloch, S and Cooper, D and Schechter, M and Tambussi, G and Fidler, S and Carrington, M and Babiker, A and Weber, J and Koelsch, KK and Kelleher, AD and Phillips, RE and Frater, J},
doi = {10.7554/eLife.03821},
journal = {eLife},
pages = {1--16},
title = {HIV-1 DNA predicts disease progression and post-treatment virological control.},
url = {http://dx.doi.org/10.7554/eLife.03821},
volume = {3},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In HIV-1 infection, a population of latently infected cells facilitates viral persistence despite antiretroviral therapy (ART). With the aim of identifying individuals in whom ART might induce a period of viraemic control on stopping therapy, we hypothesised that quantification of the pool of latently infected cells in primary HIV-1 infection (PHI) would predict clinical progression and viral replication following ART. We measured HIV-1 DNA in a highly characterised randomised population of individuals with PHI. We explored associations between HIV-1 DNA and immunological and virological markers of clinical progression, including viral rebound in those interrupting therapy. In multivariable analyses, HIV-1 DNA was more predictive of disease progression than plasma viral load and, at treatment interruption, predicted time to plasma virus rebound. HIV-1 DNA may help identify individuals who could safely interrupt ART in future HIV-1 eradication trials.
AU  - Williams,JP
AU  - Hurst,J
AU  - Stoehr,W
AU  - Robinson,N
AU  - Brown,H
AU  - Fisher,M
AU  - Kinloch,S
AU  - Cooper,D
AU  - Schechter,M
AU  - Tambussi,G
AU  - Fidler,S
AU  - Carrington,M
AU  - Babiker,A
AU  - Weber,J
AU  - Koelsch,KK
AU  - Kelleher,AD
AU  - Phillips,RE
AU  - Frater,J
DO  - 10.7554/eLife.03821
EP  - 16
PY  - 2014///
SN  - 2050-084X
SP  - 1
TI  - HIV-1 DNA predicts disease progression and post-treatment virological control.
T2  - eLife
UR  - http://dx.doi.org/10.7554/eLife.03821
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000341775900003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://elifesciences.org/articles/03821
UR  - http://hdl.handle.net/10044/1/21629
VL  - 3
ER  -
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