Imperial College London
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ProfessorJonathanWeber

Faculty of Medicine, Department of Infectious Disease

Director of the AHSC, Professor of Communicable Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3905j.weber

 
 
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Assistant

 

Mrs Siobhan Pigott +44 (0)20 7594 3901

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{The:2014:10.1097/QAD.0000000000000456,
author = {The, HIV-CAUSAL Collaboration},
doi = {10.1097/QAD.0000000000000456},
journal = {AIDS},
pages = {2461--2473},
title = {Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries},
url = {http://dx.doi.org/10.1097/QAD.0000000000000456},
volume = {28},
year = {2014}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background: There is little information on the incidence of AIDS-defining events which have been reported in the literature to be associated with immune reconstitution inflammatory syndrome (IRIS) after combined antiretroviral therapy (cART) initiation. These events include tuberculosis, mycobacterium avium complex (MAC), cytomegalovirus (CMV) retinitis, progressive multifocal leukoencephalopathy (PML), herpes simplex virus (HSV), Kaposi sarcoma, non-Hodgkin lymphoma (NHL), cryptococcosis and candidiasis.Methods: We identified individuals in the HIV-CAUSAL Collaboration, which includes data from six European countries and the US, who were HIV-positive between 1996 and 2013, antiretroviral therapy naive, aged at least 18 years, had CD4+ cell count and HIV-RNA measurements and had been AIDS-free for at least 1 month between those measurements and the start of follow-up. For each AIDS-defining event, we estimated the hazard ratio for no cART versus less than 3 and at least 3 months since cART initiation, adjusting for time-varying CD4+ cell count and HIV-RNA via inverse probability weighting.Results: Out of 96 562 eligible individuals (78% men) with median (interquantile range) follow-up of 31 [13,65] months, 55 144 initiated cART. The number of cases varied between 898 for tuberculosis and 113 for PML. Compared with non-cART initiation, the hazard ratio (95% confidence intervals) up to 3 months after cART initiation were 1.21 (0.90–1.63) for tuberculosis, 2.61 (1.05–6.49) for MAC, 1.17 (0.34–4.08) for CMV retinitis, 1.18 (0.62–2.26) for PML, 1.21 (0.83–1.75) for HSV, 1.18 (0.87–1.58) for Kaposi sarcoma, 1.56 (0.82–2.95) for NHL, 1.11 (0.56–2.18) for cryptococcosis and 0.77 (0.40–1.49) for candidiasis.Conclusion: With the potential exception of mycobacterial infections, unmasking IRIS does not appear to be a common complication of cART initiation in high-income countries.
AU  - The,HIV-CAUSAL Collaboration
DO  - 10.1097/QAD.0000000000000456
EP  - 2473
PY  - 2014///
SN  - 0269-9370
SP  - 2461
TI  - Opportunistic infections and AIDS malignancies early after initiating combination antiretroviral therapy in high-income countries
T2  - AIDS
UR  - http://dx.doi.org/10.1097/QAD.0000000000000456
UR  - http://hdl.handle.net/10044/1/40146
VL  - 28
ER  -
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