Imperial College London
Portrait Picture

ProfessorJonathanWeber

Faculty of Medicine, Department of Infectious Disease

Director of the AHSC, Professor of Communicable Diseases
 
 
 
//

Contact

 

+44 (0)20 7594 3905j.weber

 
 
//

Assistant

 

Mrs Siobhan Pigott +44 (0)20 7594 3901

 
//

Location

 

2.15Faculty BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Huntington:2015:10.1097/QAD.0000000000000620,
author = {Huntington, S and Thorne, C and Newell, M-L and Anderson, J and Taylor, GP and Pillay, D and Hill, T and Tookey, PA and Sabin, C},
doi = {10.1097/QAD.0000000000000620},
journal = {AIDS},
pages = {801--809},
title = {Pregnancy is associated with elevation of liver enzymes in HIV-positive women on antiretroviral therapy},
url = {http://dx.doi.org/10.1097/QAD.0000000000000620},
volume = {29},
year = {2015}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: The objective of this study is to assess whether pregnancy is associated with an increased risk of liver enzyme elevation (LEE) and severe LEE in HIV-positive women on antiretroviral therapy (ART).Design: Two observational studies: the UK Collaborative HIV Cohort (UK CHIC) study and the UK and Ireland National Study of HIV in Pregnancy and Childhood (NSHPC).Methods: Combined data from UK CHIC and NSHPC were used to identify factors associated with LEE (grade 1–4) and severe LEE (grade 3–4). Women starting ART in 2000–2012 were included irrespective of pregnancy status. Cox proportional hazards were used to assess fixed and time-dependent covariates including pregnancy status, CD4+ cell count, drug regimen and hepatitis B virus/hepatitis C virus (HBV/HCV) coinfection.Results: One-quarter (25.7%, 982/3815) of women were pregnant during follow-up, 14.2% (n = 541) when starting ART. The rate of LEE was 14.5/100 person-years in and 6.0/100 person-years outside of pregnancy. The rate of severe LEE was 3.9/100 person-years in and 0.6/100 person-years outside of pregnancy. The risk of LEE and severe LEE was increased during pregnancy [LEE: adjusted hazard ratio (aHR) 1.66 (1.31–2.09); severe LEE: aHR 3.57 (2.30–5.54)], including in secondary analyses excluding 541 women pregnant when starting ART. Other factors associated with LEE and severe LEE included lower CD4+ cell count (<250 cells/μl), HBV/HCV coinfection and calendar year.Conclusion: Although few women developed severe LEE, this study provides further evidence that pregnancy is associated with an increased risk of LEE and severe LEE, reinforcing the need for regular monitoring of liver biomarkers during pregnancy.
AU  - Huntington,S
AU  - Thorne,C
AU  - Newell,M-L
AU  - Anderson,J
AU  - Taylor,GP
AU  - Pillay,D
AU  - Hill,T
AU  - Tookey,PA
AU  - Sabin,C
DO  - 10.1097/QAD.0000000000000620
EP  - 809
PY  - 2015///
SN  - 0269-9370
SP  - 801
TI  - Pregnancy is associated with elevation of liver enzymes in HIV-positive women on antiretroviral therapy
T2  - AIDS
UR  - http://dx.doi.org/10.1097/QAD.0000000000000620
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000353469000006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://journals.lww.com/aidsonline/Fulltext/2015/04240/Pregnancy_is_associated_with_elevation_of_liver.6.aspx
UR  - http://hdl.handle.net/10044/1/80747
VL  - 29
ER  -
Download