Imperial College London
Portrait Picture

ProfessorJonathanWeber

Faculty of Medicine, Department of Infectious Disease

Director of the AHSC, Professor of Communicable Diseases
 
 
 
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Contact

 

+44 (0)20 7594 3905j.weber

 
 
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Assistant

 

Mrs Siobhan Pigott +44 (0)20 7594 3901

 
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Location

 

2.15Faculty BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Herath:2016:10.1016/j.vaccine.2016.07.028,
author = {Herath, S and Le, Heron A and Colloca, S and Patterson, S and Tatoud, R and Weber, J and Dickson, G},
doi = {10.1016/j.vaccine.2016.07.028},
journal = {Vaccine},
pages = {4378--4385},
title = {Strain-dependent and distinctive T-cell responses to HIV antigens following immunisation of mice with differing chimpanzee adenovirus vaccine vectors},
url = {http://dx.doi.org/10.1016/j.vaccine.2016.07.028},
volume = {34},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - In vivo vaccination studies are conventionally conducted in a single mouse strain with results, only reflecting responses to a single immunogenetic background. We decided to examine the immune response to an HIV transgene (gag, pol and nef fusion protein) in 3 strains of mice (CBA, C57BL/6 and BALB/c) to determine the spectrum of responses and in addition to determine whether the serotype of the adenoviral vector used (ChAd3 and ChAd63) impacted the outcome of response. Our results demonstrated that all three strains of mice responded to the transgene and that the magnitude of responses were different between the strains. The C57BL/6 strain showed the lowest range of responses compared to the other strains and, very few responses were seen to the same peptide pool in all three strains of mice. In CBA and BALB/c mice there were significant differences in IFNγ production dependent on the adenoviral vector used. Our results suggest that employing a single strain of mouse may underestimate the efficacy and efficiency of vaccine products.
AU  - Herath,S
AU  - Le,Heron A
AU  - Colloca,S
AU  - Patterson,S
AU  - Tatoud,R
AU  - Weber,J
AU  - Dickson,G
DO  - 10.1016/j.vaccine.2016.07.028
EP  - 4385
PY  - 2016///
SN  - 1873-2518
SP  - 4378
TI  - Strain-dependent and distinctive T-cell responses to HIV antigens following immunisation of mice with differing chimpanzee adenovirus vaccine vectors
T2  - Vaccine
UR  - http://dx.doi.org/10.1016/j.vaccine.2016.07.028
UR  - http://hdl.handle.net/10044/1/39171
VL  - 34
ER  -
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