I established my research group at Imperial College London in 2010. The group received funding from the Medical Research Council, Wellcome Trust and Kidney Research UK. Our main interest in to understand genetic variation that controls macrophage function in complex inflammatory disorders. We use animal models of inflammatory kidney disease, wound healing/fibrosis, metabolic syndrome, bone inflammation and apply systems-genetics approaches to investigate the effect of germline sequence variation on macrophage plasticity. Our recent approaches pointed towards the importance of targeting macrophage energy metabolism in inflammatory and fibrotic disease.
Our main external collaborators are Dr Enrico Petretto at Duke-NUS, Singapore (https://www.duke-nus.edu.sg/content/petretto-enrico); Dr Christian Frezza at the MRC Cancer Unit, University of Cambridge (https://www.mrc-cu.cam.ac.uk/research/Christian-frezza-folder).
In addition, we work closely with the Molecular Endocrinology Group at Imperial College London (Profs Graham Williams and Duncan Bassett) as part of an OBCD collaborator (http://www.boneandcartilage.com/phenotyping.html).
SELECTED RECENT PUBLICATIONS (2014-2019)
2019 Pereira M, Chen TD, Buang N, Olona A, Ko JH, Prendecki M, Costa ASH, Nikitopoulou E, Tronci L, Pusey CD, Cook HT, McAdoo SP, Frezza C and Behmoaras J. Acute iron deprivation reprograms human macrophage metabolism and reduces inflammation in vivo. Cell Reports. 2019 Jul 9;28(2):498-511.
2019 Bagnati M, Moreno-Moral A, Ko JH, Nicod J, Harmston N, Imprialou M, Game L, Gil J, Petretto E and Behmoaras J. Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing. JCI Insight. 2019 Jan 24;4(2)
2018 Olona A, Terra X, Ko, JH, Grau-Bové C, Pinent M, Ardevol A, Garcia Diaz A, Moreno-Moral A, Edin, M, Bishop-Bailey D, Zeldin DC, Aitman TJ, Petretto E, Blay M and Behmoaras J. Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis. Mol Metab, 2018 May;11:18-32
2018 Moreno-Moral A, Bagnati B, Koturan S, Ko, JH, Fonseca C, Harmston N, Game L, Martin J, Ong V, Abraham DJ, Denton CP, Behmoaras J, and Petretto E. Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk. Ann Rheum Dis, 2018 Apr;77(4):596-601.
2017 Papathanassiu A, Ko JH, Imprialou M, Bagnati M, Srivastava PK, Vu HA, Cucchi D, McAdoo SP, Ananieva EA, Mauro C and Behmoaras J. BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases. Nat Commun, 2017 Jul 12;8:16040.
2014. Kang H, Kerloc’h A, Rotival M, Xu X, Zhang Q, D’Souza Z, Kim M, Scholz JC, Ko JH, Srivastava PK, Genzen JR, Cui W, Aitman TJ, Game L, Melvin JE, Hanidu A, Dimock J, Zheng J, Souza D, Behera AK, Nabozny G, Cook HT, Bassett JHD, Williams GR, Li, J, Vignery A, Petretto E and Behmoaras J. Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. Cell Reports, 2014 21;8(4):1210-24.
et al., 2020, A trans-eQTL network regulates osteoclast multinucleation and bone mass, Elife, Vol:9, ISSN:2050-084X
et al., 2019, Cardiac glycosides are broad-spectrum senolytics, Nature Metabolism, Vol:1, ISSN:2522-5812, Pages:1074-1088
et al., 2019, Acute iron deprivation reprograms human macrophage metabolism and reduces inflammation in vivo, Cell Reports, Vol:28, ISSN:2211-1247, Pages:498-511.e5
et al., 2019, THE EFFECT OF P2X7 ANTAGONISM ON NEPHROTOXIC NEPHRITIS, 19th International Vasculitis and ANCA Workshop, OXFORD UNIV PRESS, Pages:93-94, ISSN:1462-0324
et al., 2019, A NOVEL P2X7 KNOCKOUT RAT IS NOT PROTECTED FROM EXPERIMENTAL GLOMERULONEPHRITIS OR VASCULITIS, 19th International Vasculitis and ANCA Workshop, OXFORD UNIV PRESS, ISSN:1462-0324