Imperial College London

DrJacquesBehmoaras

Faculty of MedicineDepartment of Medicine

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 3313 2339jacques.behmoaras Website

 
 
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Location

 

9N13Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

48 results found

Bagnati M, Moreno-Moral A, Ko J-H, Nicod J, Harmston N, Imprialou M, Game L, Gil J, Petretto E, Behmoaras Jet al., 2019, Systems genetics identifies a macrophage cholesterol network associated with physiological wound healing, JCI INSIGHT, Vol: 4, ISSN: 2379-3708

JOURNAL ARTICLE

Pereira M, Petretto E, Gordon S, Bassett JHD, Williams GR, Behmoaras Jet al., 2018, Common signalling pathways in macrophage and osteoclast multinucleation, JOURNAL OF CELL SCIENCE, Vol: 131, ISSN: 0021-9533

JOURNAL ARTICLE

Olona A, Terra X, Ko J-H, Grau-Bove C, Pinent M, Ardevol A, Diaz AG, Moreno-Moral A, Edin M, Bishop-Bailey D, Zeldin DC, Aitman TJ, Petretto E, Blay M, Behmoaras Jet al., 2018, Epoxygenase inactivation exacerbates diet and aging-associated metabolic dysfunction resulting from impaired adipogenesis, MOLECULAR METABOLISM, Vol: 11, Pages: 18-32, ISSN: 2212-8778

JOURNAL ARTICLE

Moreno-Moral A, Bagnati M, Koturan S, Ko J-H, Fonseca C, Harmston N, Game L, Martin J, Ong V, Abraham DJ, Denton CP, Behmoaras J, Petretto Eet al., 2018, Changes in macrophage transcriptome associate with systemic sclerosis and mediate GSDMA contribution to disease risk, ANNALS OF THE RHEUMATIC DISEASES, Vol: 77, Pages: 596-601, ISSN: 0003-4967

JOURNAL ARTICLE

Papathanassiu AE, Ko J-H, Imprialou M, Bagnati M, Srivastava PK, Vu HA, Cucchi D, McAdoo SP, Ananieva EA, Mauro C, Behmoaras Jet al., 2017, BCAT1 controls metabolic reprogramming in activated human macrophages and is associated with inflammatory diseases, NATURE COMMUNICATIONS, Vol: 8, ISSN: 2041-1723

JOURNAL ARTICLE

Chen T-D, Rotival M, Chiu L-Y, Bagnati M, Ko J-H, Srivastava PK, Petretto E, Pusey CD, Lai P-C, Aitman TJ, Cook HT, Behmoaras Jet al., 2017, Identification of Ceruloplasmin as a Gene that Affects Susceptibility to Glomerulonephritis Through Macrophage Function, GENETICS, Vol: 206, Pages: 1139-1151, ISSN: 0016-6731

JOURNAL ARTICLE

Rackham OJL, Langley SR, Oates T, Vradi E, Harmston N, Srivastava PK, Behmoaras J, Dellaportas P, Bottolo L, Petretto Eet al., 2017, A Bayesian Approach for Analysis of Whole-Genome Bisulfite Sequencing Data Identifies Disease-Associated Changes in DNA Methylation, GENETICS, Vol: 205, Pages: 1443-1458, ISSN: 0016-6731

JOURNAL ARTICLE

Srivastava PK, Bagnati M, Delahaye-Duriez A, Ko J-H, Rotival M, Langley SR, Shkura K, Mazzuferi M, Danis B, van Eyll J, Foerch P, Behmoaras J, Kaminski RM, Petretto E, Johnson MRet al., 2017, Genome-wide analysis of differential RNA editing in epilepsy, GENOME RESEARCH, Vol: 27, Pages: 440-450, ISSN: 1088-9051

JOURNAL ARTICLE

Moreno-Moral A, Pesce F, Behmoaras J, Petretto Eet al., 2017, Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease., Systems Genetics. Methods in Molecular Biology, Publisher: Humana Press, Pages: 337-362, ISBN: 978-1-4939-6425-3

Systems genetics stems from systems biology and similarly employs integrative modeling approaches to describe the perturbations and phenotypic effects observed in a complex system. However, in the case of systems genetics the main source of perturbation is naturally occurring genetic variation, which can be analyzed at the systems-level to explain the observed variation in phenotypic traits. In contrast with conventional single-variant association approaches, the success of systems genetics has been in the identification of gene networks and molecular pathways that underlie complex disease. In addition, systems genetics has proven useful in the discovery of master trans-acting genetic regulators of functional networks and pathways, which in many cases revealed unexpected gene targets for disease. Here we detail the central components of a fully integrated systems genetics approach to complex disease, starting from assessment of genetic and gene expression variation, linking DNA sequence variation to mRNA (expression QTL mapping), gene regulatory network analysis and mapping the genetic control of regulatory networks. By summarizing a few illustrative (and successful) examples, we highlight how different data-modeling strategies can be effectively integrated in a systems genetics study.

BOOK CHAPTER

Martinez-Micaelo N, Gonzalez-Abuin N, Terra X, Ardevol A, Pinent M, Petretto E, Behmoaras J, Blay Met al., 2016, Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet, DISEASE MODELS & MECHANISMS, Vol: 9, Pages: 1231-1239, ISSN: 1754-8403

JOURNAL ARTICLE

Vallant N, Behmoaras J, Ko J-H, Page T, Tam F, Garcia-Diaz A, Sandhu B, Pusey C, Papalois Vet al., 2016, Extraction of green fluorescent protein labelled mesenchymal stem cells to investigate their mechanisms of action on ischemia-reperfusion Injury in a rat kidney transplant model, Publisher: LIPPINCOTT WILLIAMS & WILKINS, Pages: S652-S652, ISSN: 0041-1337

CONFERENCE PAPER

Moschidou D, Corcelli M, Hau K-L, Ekwalla VJ, Behmoaras JV, De Coppi P, David AL, Bou-Gharios G, Cook HT, Pusey CD, Fisk NM, Guillot PVet al., 2016, Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome, STEM CELLS AND DEVELOPMENT, Vol: 25, Pages: 395-404, ISSN: 1547-3287

JOURNAL ARTICLE

Martinez-Micaelo N, Gonzalez-Abuin N, Ardevol A, Pinent M, Petretto E, Behmoaras J, Blay Met al., 2016, Leptin signal transduction underlies the differential metabolic response of LEW and WKY rats to cafeteria diet, JOURNAL OF MOLECULAR ENDOCRINOLOGY, Vol: 56, Pages: 1-10, ISSN: 0952-5041

JOURNAL ARTICLE

Vallant N, Sandhu B, Woollard K, Behmoaras J, Ko HJ, Garzia-Diaz A, Pusey C, Papalois Vet al., 2015, MESENCHYMAL STEM CELLS IN MACHINE PERFUSION-THE PERFECT COMBINATION TO ATTENUATE ISCHEMIA-REPERFUSION INJURY IN SOLID ORGAN TRANSPLANTATION?, Publisher: WILEY-BLACKWELL, Pages: 811-811, ISSN: 0934-0874

CONFERENCE PAPER

Dominy KM, Roufosse C, de Kort H, Willicombe M, Brookes P, Behmoaras JV, Petretto EG, Galliford J, Choi P, Taube D, Cook HT, Mclean AGet al., 2015, Use of Quantitative Real Time Polymerase Chain Reaction to Assess Gene Transcripts Associated With Antibody-Mediated Rejection of Kidney Transplants, TRANSPLANTATION, Vol: 99, Pages: 1981-1988, ISSN: 0041-1337

JOURNAL ARTICLE

Behmoaras J, Diaz AG, Venda L, Ko J-H, Srivastava P, Montoya A, Faull P, Webster Z, Moyon B, Pusey CD, Abraham DJ, Petretto E, Cook TH, Aitman TJet al., 2015, Macrophage Epoxygenase Determines a Profibrotic Transcriptome Signature, Journal of Immunology, Vol: 194, Pages: 4705-4716, ISSN: 1550-6606

Epoxygenases belong to the cytochrome P450 family. They generate epoxyeicosatrienoic acids, which are known to have anti-inflammatory effects, but little is known about their role in macrophage function. By high-throughput sequencing of RNA in primary macrophages derived from rodents and humans, we establish the relative expression of epoxygenases in these cells. Zinc-finger nuclease-mediated targeted gene deletion of the major rat macrophage epoxygenase Cyp2j4 (ortholog of human CYP2J2) resulted in reduced epoxyeicosatrienoic acid synthesis. Cyp2j4−/− macrophages have relatively increased peroxisome proliferator-activated receptor-γ levels and show a profibrotic transcriptome, displaying overexpression of a specific subset of genes (260 transcripts) primarily involved in extracellular matrix, with fibronectin being the most abundantly expressed transcript. Fibronectin expression is under the control of epoxygenase activity in human and rat primary macrophages. In keeping with the in vitro findings, Cyp2j4−/− rats show upregulation of type I collagen following unilateral ureter obstruction of the kidney, and quantitative proteomics analysis (liquid chromatography–tandem mass spectrometry) showed increased renal type I collagen and fibronectin protein abundance resulting from experimentally induced crescentic glomerulonephritis in these rats. Taken together, these results identify the rat epoxygenase Cyp2j4 as a determinant of a profibrotic macrophage transcriptome that could have implications in various inflammatory conditions, depending on macrophage function.

JOURNAL ARTICLE

Rotival M, Ko J-H, Srivastava PK, Kerloc'h A, Montoya A, Mauro C, Faull P, Cutillas PR, Petretto E, Behmoaras Jet al., 2015, Integrating Phosphoproteome and Transcriptome Reveals New Determinants of Macrophage Multinucleation, MOLECULAR & CELLULAR PROTEOMICS, Vol: 14, Pages: 484-498, ISSN: 1535-9476

JOURNAL ARTICLE

Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PLM, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo FW, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O'Brien TJ, Petrovski S, von Lehe M, Hoffmann P, Eriksson J, Coffey AJ, Cichon S, Walker M, Simonato M, Danis B, Mazzuferi M, Foerch P, Schoch S, De Paola V, Kaminski RM, Cunliffe VT, Becker AJ, Petretto Eet al., 2015, Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus, NATURE COMMUNICATIONS, Vol: 6, ISSN: 2041-1723

JOURNAL ARTICLE

Lai P-C, Chiu L-Y, Srivastava P, Trento C, Dazzi F, Petretto E, Cook HT, Behmoaras Jet al., 2014, Unique Regulatory Properties of Mesangial Cells Are Genetically Determined in the Rat, PLOS ONE, Vol: 9, ISSN: 1932-6203

JOURNAL ARTICLE

Kang H, Kerloc'h A, Rotival M, Xu X, Zhang Q, D'Souza Z, Kim M, Scholz JC, Ko J-H, Srivastava PK, Genzen JR, Cui W, Aitman TJ, Game L, Melvin JE, Hanidu A, Dimock J, Zheng J, Souza D, Behera AK, Nabozny G, Cook HT, Bassett JHD, Williams GR, Li J, Vignery A, Petretto E, Behmoaras Jet al., 2014, Kcnn4 Is a Regulator of Macrophage Multinucleation in Bone Homeostasis and Inflammatory Disease, CELL REPORTS, Vol: 8, Pages: 1210-1224, ISSN: 2211-1247

JOURNAL ARTICLE

D'Souza Z, McAdoo SP, Smith J, Pusey CD, Cook HT, Behmoaras J, Aitman TJet al., 2013, Experimental crescentic glomerulonephritis: a new bicongenic rat model, DISEASE MODELS & MECHANISMS, Vol: 6, Pages: 1477-1486, ISSN: 1754-8403

JOURNAL ARTICLE

Slove S, Lannoy M, Behmoaras J, Pezet M, Sloboda N, Lacolley P, Escoubet B, Bujan J, Jacob M-Pet al., 2013, Potassium Channel Openers Increase Aortic Elastic Fiber Formation and Reverse the Genetically Determined Elastin Deficit in the BN Rat, HYPERTENSION, Vol: 62, Pages: 794-+, ISSN: 0194-911X

JOURNAL ARTICLE

Srivastava PK, Hull RP, Behmoaras J, Petretto E, Aitman TJet al., 2013, JunD/AP1 regulatory network analysis during macrophage activation in a rat model of crescentic glomerulonephritis, BMC SYSTEMS BIOLOGY, Vol: 7, ISSN: 1752-0509

JOURNAL ARTICLE

Moschidou D, Sharp P, Behmoaras J, David A, De Coppi P, Bou-Gharios G, Fisk N, Pusey C, Cook T, Guillot Pet al., 2013, Potential of human fetal chorionic stem cell therapy for Alport Syndrome, Conference of the British-Society-for-Gene-and-Cell-Therapy (BSGCT), Publisher: MARY ANN LIEBERT INC, Pages: A12-A12, ISSN: 1043-0342

CONFERENCE PAPER

McLean A, Dominy K, De Kort H, Brookes P, Behmoaras J, Galliford J, Roufosse C, Cook T, Willicombe M, Taube Det al., 2013, Intra-Graft Expression of Transcripts for Endothelial Activation and NK Cell Markers, Detected by Real-Time qPCR, Is Associated with the Presence of Donor Specific Antibodies, and Identifies Kidney Transplants at Risk of Failure, 13th American Transplant Congress (ATC), Publisher: WILEY-BLACKWELL, Pages: 142-142, ISSN: 1600-6135

CONFERENCE PAPER

Mcdaid JP, Tanna A, Bhangal G, Little MA, Behmoaras J, Cook HT, Tam FW, Salama AD, Pusey CDet al., 2013, The role of quantitative trait loci (QTL) in the pathogenesis of experimental autoimmune vasculitis (EAV), Publisher: MASSON EDITEUR, Pages: 688-688, ISSN: 0755-4982

CONFERENCE PAPER

Hull RP, Srivastava PK, D'Souza Z, Atanur SS, Mechta-Grigoriou F, Game L, Petretto E, Cook HT, Aitman TJ, Behmoaras Jet al., 2013, Combined ChIP-Seq and transcriptome analysis identifies AP-1/JunD as a primary regulator of oxidative stress and IL-1 beta synthesis in macrophages, BMC GENOMICS, Vol: 14, ISSN: 1471-2164

JOURNAL ARTICLE

Deplano S, Cook HT, Russell R, Franchi L, Schneiter S, Bhangal G, Unwin RJ, Pusey CD, Tam FWK, Behmoaras Jet al., 2013, P2X7 receptor-mediated Nlrp3-inflammasome activation is a genetic determinant of macrophage-dependent crescentic glomerulonephritis, JOURNAL OF LEUKOCYTE BIOLOGY, Vol: 93, Pages: 127-134, ISSN: 0741-5400

JOURNAL ARTICLE

Reynolds J, Cook PR, Behmoaras J, Smith J, Bhangal G, Tadros S, Tee J, Salama AD, Evans DJ, Aitman TJ, Cook HT, Pusey CDet al., 2012, Genetic Susceptibility to Experimental Autoimmune Glomerulonephritis in the Wistar Kyoto Rat, AMERICAN JOURNAL OF PATHOLOGY, Vol: 180, Pages: 1843-1851, ISSN: 0002-9440

JOURNAL ARTICLE

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