Imperial College London
Alternate

DrJacquesBehmoaras

Faculty of Medicine, Department of Immunology and Inflammation

Reader in Immunogenetics
 
 
 
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Contact

 

+44 (0)20 3313 2339jacques.behmoaras Website

 
 
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Location

 

9N13Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Behmoaras:2021:10.1083/jcb.202010162,
author = {Behmoaras, J and Gil, J},
doi = {10.1083/jcb.202010162},
journal = {The Journal of Cell Biology},
title = {Similarities and interplay between senescent cells and macrophages},
url = {http://dx.doi.org/10.1083/jcb.202010162},
volume = {220},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Senescence is a cellular program that prevents the replication of old, damaged, or cancerous cells. Senescent cells become growth arrested and undergo changes in their morphology, chromatin organization, and metabolism, and produce a bioactive secretome. This secretome, the senescence-associated secretory phenotype (SASP), mediates many of the pathophysiological effects associated with senescent cells, for example, recruiting and activating immune cells such as macrophages. The relation between senescent cells and macrophages is intriguing: senescent cells recruit macrophages, can induce them to undergo senescence, or can influence their polarization. Senescent cells and macrophages share multiple phenotypic characteristics; both have a high secretory status, increased lysosome numbers, or the ability to activate the inflammasome. Senescent cells accumulate during aging and disease, and killing them results in widespread benefits. Here we discuss similarities between senescent cells and macrophages and interpret the latest developments in macrophage biology to understand the molecular mechanisms of cellular senescence. We describe evidence and effects of senescence in macrophages and speculate on the ontogeny of the senescent-like state in macrophages. Finally, we examine the macrophage–senescent cell interplay and its impact on macrophage effector functions during inflammatory conditions and in the tumor microenvironment.
AU  - Behmoaras,J
AU  - Gil,J
DO  - 10.1083/jcb.202010162
PY  - 2021///
SN  - 0021-9525
TI  - Similarities and interplay between senescent cells and macrophages
T2  - The Journal of Cell Biology
UR  - http://dx.doi.org/10.1083/jcb.202010162
UR  - http://hdl.handle.net/10044/1/86495
VL  - 220
ER  -
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